Alanna J. Church, MD
Associate Director, Laboratory for Molecular Pediatric Pathology (LaMPP); Molecular Pathology
Assistant Professor of Pathology, Harvard Medical School
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Alanna J. Church, MD
Associate Director, Laboratory for Molecular Pediatric Pathology (LaMPP); Molecular Pathology
Assistant Professor of Pathology, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Queen's University
2006
Kingston, Ontario
Canada
Residency
Queen's University
2012
Kingston, Ontatio
Canada
Fellowship
Harvard Medical School
2013
Boston
MA
Fellowship
Brigham and Women's Hospital
2014
Boston
MA
Fellowship
Boston Children's Hospital
2016
Boston
MA
Certifications
American Board of Pathology (Anatomic Clinical Pathology)
American Board of Pathology (Anatomic Molecular Genetics)
American Board of Pathology (Pediatric)
Publications
Patient-centered integration of tumor and germline genetic results can improve cancer care. View Abstract
A New Era for Molecular Diagnostics: Reclaiming Strategic Vision for Patient Care. View Abstract
Pediatric-type Myoid Neoplasms of Somatic Soft Tissue: A Clinicopathological and Molecular Genetic Study of 78 Tumors, Highlighting Indolent Clinical Behavior and Frequent SRF Gene Rearrangements. View Abstract
Molecular characterization informs prognosis in patients with localized Ewing sarcoma: A report from the Children's Oncology Group. View Abstract
Larotrectinib for Newly Diagnosed Infantile Fibrosarcoma and Other Pediatric NTRK Fusion-Positive Solid Tumors (Children's Oncology Group ADVL1823). View Abstract
Molecular Diagnostics in Pediatric Pathology Practice: Current Trends and Development. View Abstract
The implementation of molecular tumor profiling in the practice of pediatric cancer pathology: The pathologists' experience. View Abstract
Author Correction: Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Neuroblastoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology. View Abstract
ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs. View Abstract
Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. View Abstract
Molecular Alterations in Pediatric Solid Tumors. View Abstract
Promise and Perils of Precision Oncology for Patients With Pediatric and Young Adult Sarcomas. View Abstract
Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series. View Abstract
Section E6.7-6.12 of the American College of Medical Genetics and Genomics (ACMG) Technical Laboratory Standards: Cytogenomic studies of acquired chromosomal abnormalities in solid tumors. View Abstract
CTNNB1 and APC Mutations in Sinonasal Myxoma : Expanding the Spectrum of Tumors Driven By WNT/ß-catenin Pathway. View Abstract
STK11 Adnexal Tumor in an Adolescent Female: Diagnostic Pitfalls of a Recently Described Entity. View Abstract
Splenic Lymphatic Malformation With Papillary Endothelial Proliferation: A Rare Histologic Variant or a Unique Entity? View Abstract
A single-institution pediatric and young adult interventional oncology collaborative: Novel therapeutic options for relapsed/refractory solid tumors. View Abstract
Current Utilization of Electron Microscopy in the Pediatric Pathology Setting: A Survey by the SPP Practice Committee. View Abstract
Genomic analysis reveals germline and somatic PDGFRB variants with clinical implications in familial infantile myofibromatosis. View Abstract
Clinical Targeted Next-Generation Panel Sequencing Reveals MYC Amplification Is a Poor Prognostic Factor in Osteosarcoma. View Abstract
Expanding the Spectrum of Perioral Myogenic Tumors in Pediatric Patients: An SRF::NCOA2 Fused Perivascular Tumor of the Philtrum. View Abstract
Rare FGFR Oncogenic Alterations in Sequenced Pediatric Solid and Brain Tumors Suggest FGFR Is a Relevant Molecular Target in Childhood Cancer. View Abstract
Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group. View Abstract
Special Considerations in the Molecular Diagnostics of Pediatric Neoplasms. View Abstract
Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer. View Abstract
Gamma Secretase Inhibition for a Child With Metastatic Glomus Tumor and Activated NOTCH1. View Abstract
Histologic characterization of paediatric mesenchymal neoplasms treated with kinase-targeted therapy. View Abstract
Thyroid Nodules in Children With Familial Adenomatous Polyposis. View Abstract
Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions. View Abstract
Genomic comparison of malignant melanoma and atypical Spitz tumor in the pediatric population. View Abstract
Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor. View Abstract
Molecular Characterization of Inflammatory Tumors Facilitates Initiation of Effective Therapy. View Abstract
Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing. View Abstract
Molecular Alterations in Pediatric Solid Tumors. View Abstract
A Curriculum for Genomic Education of Molecular Genetic Pathology Fellows: A Report of the Association for Molecular Pathology Training and Education Committee. View Abstract
Fibrolamellar carcinoma: An entity all its own. View Abstract
Undifferentiated Embryonal Sarcoma of the Liver With Rhabdoid Morphology Mimicking Carcinoma: Expanding the Morphologic Spectrum or a Distinct Variant? View Abstract
Natural History of Thyroid Disease in Children with PTEN Hamartoma Tumor Syndrome. View Abstract
A case of metastatic adenocarcinoma of unknown primary in a pediatric patient: Opportunities for precision medicine. View Abstract
PD-1 and PD-L1 Expression in Osteosarcoma: Which Specimen to Evaluate? View Abstract
Clinical Pan-Cancer Assessment of Mismatch Repair Deficiency Using Tumor-Only, Targeted Next-Generation Sequencing. View Abstract
New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. View Abstract
Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use. View Abstract
Recurrent RET gene fusions in paediatric spindle mesenchymal neoplasms. View Abstract
Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma. View Abstract
DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor. View Abstract
Genomic and Immunologic Characterization of INI1-Deficient Pediatric Cancers. View Abstract
Recurrent and novel USP6 fusions in cranial fasciitis identified by targeted RNA sequencing. View Abstract
A Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma. View Abstract
A Distinctive Genomic and Immunohistochemical Profile for NOTCH3 and PDGFRB in Myofibroma With Diagnostic and Therapeutic Implications. View Abstract
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. View Abstract
A somatic activating NRAS variant associated with kaposiform lymphangiomatosis. View Abstract
A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma. View Abstract
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. View Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. View Abstract
Assigning clinical meaning to somatic and germ-line whole-exome sequencing data in a prospective cancer precision medicine study. View Abstract
Institutional implementation of clinical tumor profiling on an unselected cancer population. View Abstract
Integrated genetic and pharmacologic interrogation of rare cancers. View Abstract
Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study. View Abstract
Chromosome 12p abnormalities and IMP3 expression in prepubertal pure testicular teratomas. View Abstract
Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma. View Abstract
MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. View Abstract
Spreading depression expands traumatic injury in neocortical brain slices. View Abstract
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