Amy O'Connell, MD, PhD
Physician in Medicine, Division of Newborn Medicine; Director of Infection Control, Neonatal ICU; Faculty, Neonatal Genomics Program
Assistant Professor of Pediatrics, Harvard Medical School
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Amy O'Connell, MD, PhD
Physician in Medicine, Division of Newborn Medicine; Director of Infection Control, Neonatal ICU; Faculty, Neonatal Genomics Program
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Merrimack College
2002
North Andover
MA
Medical School
Jefferson Medical College, Thomas Jefferson University
2009
Philadelphia
PA
Internship
Fletcher Allen Health Care, University of Vermont
2010
Burlington
VT
Residency
Pediatrics
Fletcher Allen Health Care, University of Vermont
2012
Burlington
VT
Fellowship
Allergy & Immunology
Boston Children's Hospital
2014
Boston
MA
Fellowship
Harvard Neonatal-Perinatal Medicine Training Program
2016
Boston
MA
Certifications
American Board of Pediatrics (Neonatal-Perinatal Medicine)
American Board of Allergy & Immunology (General)
American Board of Pediatrics (General)
Professional History
Dr. Amy O’Connell is a physician scientist who has clinical training in pediatrics, allergy/immunology, and neonatology. She attended medical and graduate school at what is now Jefferson University in Philadelphia and did her pediatrics residency at the University of Vermont. She has been in Boston since 2012 when she started her fellowship training at Boston Children’s Hospital, completing fellowships in allergy/immunology in 2014 and neonatal perinatal medicine in 2017. Her research focuses on developmental biology and neonatal immunity. The biggest focuses of the laboratory are intestinal stem cell biology and immune maturation in former preterm infants.
Approach to Care
My passion is taking care of critically ill babies and their families in a team-centered environment, and that is why I am a neonatologist at Boston Children’s Hospital. I help babies and infants with respiratory failure, congenital heart disease, prematurity, complex surgical problems, and a host of other diseases, from the common to the rare. In addition, I oversee infection control for the unit and make sure we are always doing our best to minimize the risk of hospital-acquired infections.
Publications
Necrotizing enterocolitis causes increased ileal goblet cell loss in Wnt2b KO mice. View Abstract
Cataloguing the postnatal small intestinal transcriptome during the first postnatal month. View Abstract
A 4-Month-Old With Jaundice, Lethargy, and Emesis. View Abstract
Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. View Abstract
M1 and M2 Macrophages Differentially Regulate Colonic Crypt Renewal. View Abstract
Applying the bronchopulmonary dysplasia framework to necrotizing enterocolitis. View Abstract
WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. View Abstract
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota. View Abstract
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. View Abstract
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. View Abstract
Ectopic Rod Photoreceptor Development in Mice with Genetic Deficiency of WNT2B. View Abstract
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota. View Abstract
A sepsis trigger tool reduces time to antibiotic administration in the NICU. View Abstract
Premature Infants Have Normal Maturation of the T Cell Receptor Repertoire at Term. View Abstract
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation. View Abstract
Identifying Neonates at Lowest Risk for Sepsis. View Abstract
Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis. View Abstract
Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. View Abstract
Gene and Stem Cell Therapies for Fetal Care: A Review. View Abstract
Primary immunodeficiency testing in a Massachusetts tertiary care NICU: persistent challenges in the extremely premature population. View Abstract
Hypersensitivity to tetracyclines: Skin testing, graded challenge, and desensitization regimens. View Abstract
Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. View Abstract
Primary Immunodeficiency in the NICU. View Abstract
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. View Abstract
Duplicate skin prick testing in the assessment of food allergy. View Abstract
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. View Abstract
NeoReviews View Abstract
Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome. View Abstract
Paravertebral mushroom: identification of a novel species of Phellinus as a human pathogen in chronic granulomatous disease. View Abstract
Successful desensitization to brentuximab vedotin after anaphylaxis. View Abstract
Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. View Abstract
Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. View Abstract
Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. View Abstract
IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages. View Abstract
Locations