Craig Platt, MD, PhD
Immunologist, Division of Immunology; Director, Flow Cytometry
Assistant Professor of Pediatrics, Harvard Medical School
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Craig Platt, MD, PhD
Immunologist, Division of Immunology; Director, Flow Cytometry
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Graduate School
PhD
Yale School of Medicine
2010
New Haven
CT
Medical School
Yale School of Medicine
2010
New Haven
CT
Residency
Boston Children’s Hospital
2013
Boston
MA
Fellowship
Allergy/Immunology
Boston Children’s Hospital
2016
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Allergy & Immunology (General)
Professional History
Dr. Platt serves as an expert for the Division of Immunology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.
Publications
Flow Cytometry-based Immune Phenotyping of T and B Lymphocytes in the Evaluation of Immunodeficiency and Immune Dysregulation. View Abstract
Incidence and risk factors for CMV and EBV infection in infants with low T-cell receptor excision circles on newborn screen. View Abstract
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-a biologic therapy. View Abstract
T cell and autoantibody profiling for primary immune regulatory disorders. View Abstract
Curation of gene-disease relationships in primary antibody deficiencies using the ClinGen validation framework. View Abstract
Flow Cytometry-based Immune Phenotyping of T and B Lymphocytes in the Evaluation of Immunodeficiency and Immune Dysregulation. View Abstract
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with altered cornification and specific T cell expansion in atopic dermatitis. View Abstract
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity. View Abstract
A case of neonatal sweet syndrome associated with mevalonate kinase deficiency. View Abstract
The Integration of Patient-Reported Quality of Life and Systemic Biomarkers in Patients with Immune Dysregulation. View Abstract
Rethinking Immunological Risk: A Retrospective Cohort Study of Severe SARS-Cov-2 Infections in Individuals With Congenital Immunodeficiencies. View Abstract
Clinical utility of measuring CD4+ T follicular cells in patients with immune dysregulation. View Abstract
Severe congenital neutropenia due to jagunal homolog 1 (JAGN1) mutation: a case report and literature review. View Abstract
Clinical utility of measuring CD4 + T follicular cells in patients with immune dysregulation. View Abstract
Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies. View Abstract
Comparison of disease phenotypes and mechanistic insight on causal variants in patients with DADA2. View Abstract
Immune dysregulation caused by homozygous mutations in CBLB. View Abstract
A homozygous truncating mutation of FGL2 is associated with immune dysregulation. View Abstract
Simultaneous Late, Late-Onset Group B Streptococcal Meningitis in Identical Twins. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. View Abstract
Spontaneous resolution of severe idiopathic T cell lymphopenia. View Abstract
Digenic inheritance of IL-36RA and SEC61A1 mutations underlies generalized pustular psoriasis with hypogammaglobulinemia. View Abstract
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). View Abstract
Therapeutic options for CTLA-4 insufficiency. View Abstract
Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency. View Abstract
Pulmonary manifestations of immune dysregulation in CTLA-4 haploinsufficiency and LRBA deficiency. View Abstract
Ten Years of Newborn Screening for Severe Combined Immunodeficiency (SCID) in Massachusetts. View Abstract
Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. View Abstract
Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. View Abstract
Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs. View Abstract
Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. View Abstract
Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. View Abstract
A family history of SCID and unrevealing WES: An approach to management and guidance of patients. View Abstract
Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! View Abstract
A Case of STK4 Deficiency with Complications Evoking Mycobacterial Infection. View Abstract
Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). View Abstract
Dysregulated actin dynamics in activated PI3Kd syndrome. View Abstract
Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology. View Abstract
A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation. View Abstract
A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis. View Abstract
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. View Abstract
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. View Abstract
Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. View Abstract
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. View Abstract
A quality improvement initiative to increase access to food challenges. View Abstract
Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. View Abstract
Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. View Abstract
Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. View Abstract
The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils. View Abstract
Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. View Abstract
Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site. View Abstract
Skin testing, graded challenge, and desensitization to von Willebrand factor (VWF) products in type III von Willebrand disease (VWD). View Abstract
Rituximab Desensitization in Pediatric Patients: Results of a Case Series. View Abstract
A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. View Abstract
Gene hunting in the genomic era: approaches to diagnostic dilemmas in patients with primary immunodeficiencies. View Abstract
Mature dendritic cells use endocytic receptors to capture and present antigens. View Abstract
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. View Abstract
Transcript initiation, polyadenylation, and functional promoter mapping for the dihydrofolate reductase-thymidylate synthase gene of Toxoplasma gondii. View Abstract
Locations