Edward Robert Smith, MD, MBA

Vice Chair, Department of Neurosurgery, Co-Director, Cerebrovascular Surgery and Interventions Center

Professor, Harvard Medical School

Phone 617-355-8414

Fax 617-730-7636

NPI 1609846096

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Edward Robert Smith, MD, MBA

Vice Chair, Department of Neurosurgery, Co-Director, Cerebrovascular Surgery and Interventions Center

Professor, Harvard Medical School

Medical Services

Languages

English

Education

Undergraduate School

Dartmouth College

1992

Hanover

Medical School

Columbia University

1996

New York

Internship

Surgery

Massachusetts General Hospital

1997

Boston

Residency

Neurosurgery

Massachusetts General Hospital

2003

Boston

Fellowship

Pediatric Neurosurgery

Boston Children's Hospital

2004

Boston

Graduate School

Massachusetts Institute of Technology

2023

Cambridge

Media

Caregiver Profile

Meet Dr. Edward Robert Smith

Certifications

American Board of Neurological Surgery

American Board of Pediatric Neurological Surgery

Professional History

Dr. Smith is a professor of neurosurgery at Harvard Medical School, the R. Michael Scott Chair in Neurosurgery at Boston Children’s Hospital, and the Co-Director of the Cerebrovascular Surgery and Interventions Center. Dr. Smith’s training included an undergraduate education at Dartmouth College, medical school at the Columbia University College of Physicians and Surgeons, surgical internship and neurosurgical residency at the Massachusetts General Hospital, pediatric neurosurgery fellowship at the Boston Children’s Hospital/Harvard Medical School program and an NIH-funded postdoctoral training in the Vascular Biology Program with Dr. Marsha Moses. He currently heads a translational research laboratory in the Vascular Biology Program with a focus on the development of non-invasive biomarkers and novel therapeutics for pediatric brain tumors and stroke. Along with Dr. Darren Orbach, leads one of the largest pediatric cerebrovascular programs in the country, with a dedicated team focused on improving the outcomes of patients with moyamoya, aneurysms, arteriovenous malformations, and cavernous malformations.

Approach to Care

I believe strongly in my role as a surgeon/scientist, and, in the laboratory, am lucky to have been mentored by Marsha A. Moses, a great scientist and the director of the Vascular Biology Program here at Boston Children's. I'm a New Englander, having grown up in Dartmouth, MA, followed by my undergraduate years studying biology and rowing at Dartmouth College. My patients often give me joke books, which might be a reflection of my sense of (or lack of!) humor and desire to try to keep kids laughing if at all possible during difficult circumstances.

Publications

Cavernous Malformations of the Central Nervous System. Reply. View Abstract

Pediatric Cerebral Vascular Malformations : Current and Future Perspectives. View Abstract

Rupture risk and outcomes of giant aneurysms in pediatric patients: a multi-institutional case series and systematic review. View Abstract

Discovery and Characterization of Ephrin B2 and EphB4 Dysregulation and Novel Mutations in Cerebral Cavernous Malformations: In Vitro and Patient-Derived Evidence of Ephrin-Mediated Endothelial Cell Pathophysiology. View Abstract

Prevention of postoperative stroke in pediatric moyamoya patients: a standardized perioperative care protocol. View Abstract

Posterior cerebral territory ischemia in pediatric moyamoya: Surgical techniques and long-term clinical and radiographic outcomes. View Abstract

Disease specific urinary biomarkers in the central nervous system. View Abstract

Benefits and limitations of a dual faculty neurosurgeon approach to resection of pediatric craniopharyngioma. View Abstract

Direct Transverse Sinus Puncture for Transvenous Coil Embolization of Vein of Galen Malformations: Innovating Existing Techniques. View Abstract

Yield of genetic evaluation in non-syndromic pediatric moyamoya patients. View Abstract

Non-vascular intracranial lesions in three children with PHACE association. View Abstract

Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease. View Abstract

Pediatric Moyamoya Revascularization Perioperative Care: A Modified Delphi Study. View Abstract

Evolution of clinical and translational advances in the management of pediatric arteriovenous malformations. View Abstract

Comment on: Highlight: Is smoke the signal for surgery? Should the moyamoya syndrome "puff of smoke" trigger cerebral revascularization surgery in children with sickle cell disease? View Abstract

Cerebral revascularization surgery reduces cerebrovascular events in children with sickle cell disease and moyamoya syndrome: Results of the stroke in sickle cell revascularization surgery retrospective study. View Abstract

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations. View Abstract

Morning glory disc anomaly and its implications in moyamoya arteriopathy: a retrospective case series. View Abstract

Diffusion-Weighted Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children With Moyamoya Without Stroke or Silent Infarct. View Abstract

Letter: Wide Arterial Sparing Encephalo-Duro-Synangiosis for Moyamoya: Surgical Technique and Outcomes. View Abstract

External validation of the R2eD AVM scoring system to assess rupture risk in pediatric AVM patients. View Abstract

Magnetic Resonance Imaging/Angiography Versus Catheter Angiography for Annual Follow-up of Pediatric Moyamoya Patients: A Cost Outcomes Analysis. View Abstract

Practice variability in the perioperative management of pediatric moyamoya disease in North America. View Abstract

Pediatric Moyamoya Syndrome Secondary to Tuberculous Meningitis: A Case Report. View Abstract

Increasing precision in the management of pediatric neurosurgical cerebrovascular diseases with molecular genetics. View Abstract

The composition of landmark vein of Galen malformation research: the emergence of endovascular treatments. View Abstract

Pediatric Moyamoya Biomarkers: Narrowing the Knowledge Gap. View Abstract

A national analysis of 9655 pediatric cerebrovascular malformations: effect of hospital volume on outcomes. View Abstract

Noninvasive Thermal Evaluation of Ventriculoperitoneal Shunt Patency and Cerebrospinal Fluid Flow Using a Flow Enhancing Device. View Abstract

Erratum. Results of more than 20 years of follow-up in pediatric patients with moyamoya disease undergoing pial synangiosis. View Abstract

ITGA2 as a potential nanotherapeutic target for glioblastoma. View Abstract

General Principles for Preoperative Planning and Microsurgical Treatment of Pediatric Brain Arteriovenous Malformations: 2-Dimensional Operative Video. View Abstract

Results of more than 20 years of follow-up in pediatric patients with moyamoya disease undergoing pial synangiosis. View Abstract

Letter to the Editor. Bypass and revascularization in young moyamoya patients. View Abstract

General Principles for Pial Synangiosis in Pediatric Moyamoya Patients: 2-Dimensional Operative Video. View Abstract

Acute fatal hemorrhage from previously undiagnosed cerebral arteriovenous malformations in children: a single-center experience. View Abstract

Whole Exome Sequencing Reveals a Monogenic Cause of Disease in ˜43% of 35 Families With Midaortic Syndrome. View Abstract

Human genetics and molecular mechanisms of vein of Galen malformation. View Abstract

Multimodal treatment approach in a patient with multiple intracranial myxomatous aneurysms. View Abstract

Sickle Cell Disease. View Abstract

Incidence, clinical features, and treatment of familial moyamoya in pediatric patients: a single-institution series. View Abstract

Real-Time Ultrasound-Guided Catheter Navigation for Approaching Deep-Seated Brain Lesions: Role of Intraoperative Neurosonography with and without Fusion with Magnetic Resonance Imaging. View Abstract

Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. View Abstract

National Analysis of 2454 Pediatric Moyamoya Admissions and the Effect of Hospital Volume on Outcomes. View Abstract

Structural causes of ischemic and hemorrhagic stroke in children: moyamoya and arteriovenous malformations. View Abstract

The natural history of cerebral cavernous malformations in children. View Abstract

Moyamoya Biomarkers. View Abstract

Safety of neuroangiography and embolization in children: complication analysis of 697 consecutive procedures in 394 patients. View Abstract

Down syndrome and moyamoya: clinical presentation and surgical management. View Abstract

Intracranial aneurysms in the youngest patients: characteristics and treatment challenges. View Abstract

Microsurgical treatment of arteriovenous malformations in pediatric patients: the Boston Children's Hospital experience. View Abstract

Moyamoya syndrome associated with Alagille syndrome: outcome after surgical revascularization. View Abstract

Benign triton tumor: multidisciplinary approach to diagnosis and treatment. View Abstract

Management of brain arteriovenous malformations. View Abstract

Spontaneous regression of an epidermoid cyst of the cavernous sinus. View Abstract

Occipital pial synangiosis. View Abstract

Pial synangiosis in patients with moyamoya younger than 2 years of age. View Abstract

Treatment of Moyamoya disease in the adult population with pial synangiosis. View Abstract

Resection of supratentorial lobar cavernous malformations in children: clinical article.. View Abstract

Imaging after direct and indirect extracranial-intracranial bypass surgery. View Abstract

Cavernous malformations of the basal ganglia in children. View Abstract

Predictors of neoplastic disease in children with isolated pituitary stalk thickening. View Abstract

Vascular collateralization along ventriculoperitoneal shunt catheters in moyamoya disease. View Abstract

Moyamoya disease with mesial temporal sclerosis. View Abstract

Moyamoya syndrome associated with neurofibromatosis Type 1: perioperative and long-term outcome after surgical revascularization. View Abstract

Chorea in the clinical presentation of moyamoya disease: results of surgical revascularization and a proposed clinicopathological correlation. View Abstract

Moyamoya arteriopathy. View Abstract

168 Moyamoya Syndrome Associated with Neurofibromatosis Type 1 in Children. View Abstract

Spontaneous occlusion of the circle of Willis in children: pediatric moyamoya summary with proposed evidence-based practice guidelines. A review. View Abstract

Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations. View Abstract

Intraoperative anaphylaxis induced by the gelatin component of thrombin-soaked gelfoam in a pediatric patient. View Abstract

Dural arteriovenous fistulae in pediatric patients: associated conditions and treatment outcomes. View Abstract

Pial arteriovenous fistulae in pediatric patients: associated syndromes and treatment outcome. View Abstract

Incidentally discovered lesions. View Abstract

Discovery of asymptomatic moyamoya arteriopathy in pediatric syndromic populations: radiographic and clinical progression. View Abstract

Features of the lumbar spine on magnetic resonance images following sectioning of filum terminale. View Abstract

Moyamoya disease in children with congenital dwarfing conditions. View Abstract

A rare case of psammomatoid ossifying fibroma in the sphenoid bone reconstructed using autologous particulate exchange cranioplasty. View Abstract

Dural scalp and intracranial hemangiomas causing hydrocephalus and venous sinus thrombosis in an infant. View Abstract

Idiopathic syrinx in the pediatric population: a combined center experience. View Abstract

Cavernous malformations. View Abstract

Moyamoya: epidemiology, presentation, and diagnosis. View Abstract

Preface: introduction to pediatric vascular neurosurgery. View Abstract

Introduction: moyamoya disease. View Abstract

Pial synangiosis in patients with moyamoya syndrome and sickle cell anemia: perioperative management and surgical outcome. View Abstract

Intracranial vasospasm with subsequent stroke after traumatic subarachnoid hemorrhage in a 22-month-old child. View Abstract

Seckel syndrome and moyamoya. View Abstract

Moyamoya disease and moyamoya syndrome. View Abstract

Identification of an association between Robinow syndrome and moyamoya. View Abstract

A novel TP53 germline mutation in a family with a history of multiple malignancies: case report and review of the literature. View Abstract

Pediatric brain tumors. View Abstract

Foramen magnum stenosis from overgrowth of the opisthion in a child with achondroplasia. View Abstract

Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. View Abstract

Urinary biomarkers predict brain tumor presence and response to therapy. View Abstract

Progression of disease in unilateral moyamoya syndrome. View Abstract

Acute hydrocephalus secondary to obstruction of the foramen of monro and cerebral aqueduct caused by a choroid plexus cyst in the lateral ventricle. Case report. View Abstract

Tethered cord syndrome. View Abstract

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. View Abstract

Multiple pilocytic astrocytomas of the cerebellum in a 17-year-old patient with neurofibromatosis type I. View Abstract

Wound complications associated with the use of bovine serum albumin-glutaraldehyde surgical adhesive in pediatric patients. View Abstract

Is there a "July phenomenon" in pediatric neurosurgery at teaching hospitals? View Abstract

Lumbar intramedullary spinal schistosomiasis presenting as progressive paraparesis: case report. View Abstract

Moyamoya syndrome associated with Down syndrome: outcome after surgical revascularization. View Abstract

913 Moyamoya Associated with Down Syndrome: Outcome after Surgical Revascularization. View Abstract

Surgical management of moyamoya syndrome. View Abstract

Cerebral pathophysiology and critical care neurology: basic hemodynamic principles, cerebral perfusion, and intracranial pressure. View Abstract

Neurosurgical aspects of critical care neurology. View Abstract

Craniotomy for resection of pediatric brain tumors in the United States, 1988 to 2000: effects of provider caseloads and progressive centralization and specialization of care. View Abstract

In-hospital mortality rates after ventriculoperitoneal shunt procedures in the United States, 1998 to 2000: relation to hospital and surgeon volume of care. View Abstract

Far posterior subtemporal approach to the dorsolateral brainstem and tentorial ring: technique and clinical experience. View Abstract

Proposed use of prophylactic decompressive craniectomy in poor-grade aneurysmal subarachnoid hemorrhage patients presenting with associated large sylvian hematomas. View Abstract

Surgical approaches to vascular anomalies of the child's brain. View Abstract

Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. View Abstract

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