Janet Soul, MDCM
Director, Fetal-Neonatal Neurology Program
Associate Professor of Neurology, Harvard Medical School
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Janet Soul, MDCM
Director, Fetal-Neonatal Neurology Program
Associate Professor of Neurology, Harvard Medical School
Medical Services
Languages
English
French
Education
Undergraduate School
McGill University
Montreal, Quebec
Canada
Medical School
McGill University
Montreal, Quebec
Canada
Residency
Pediatrics
Boston City Hospital
Boston
MA
Fellowship
Neurology & Neonatal Neurology
Boston Children's Hospital
Boston
MA
Certifications
American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
Professional History
Dr. Janet Soul is the Director of the Fetal-Neonatal Neurology Program where she and her team provide care to fetuses, newborns, and children whose neurologic disorders begin in utero or during the newborn period. This multidisciplinary clinical program also provides specialized training for neurology, neonatology and pediatric fellows, residents, and medical students.
Dr. Soul’s clinical research is focused on improving the management and outcome of neonatal seizures and brain injury, particularly hypoxic-ischemic brain injury. She led a randomized, double-blind, controlled trial of bumetanide to treat neonatal seizures (NCT00830531), the first neonatal seizure trial to employ a standard therapy control group. She co-chaired the Seizure Workgroup of the International Neonatal Consortium (Critical Path Institute) to develop consensus recommendations for design of neonatal seizure treatment trials. She has been funded by the NIH, March of Dimes, Hood Foundation, United Cerebral Palsy Foundation, and others, and has served on DSMBs for NIH-funded multicenter trials. Dr. Soul has held leadership roles in the major societies and committees; she serves on the Board of the Newborn Brain Society as the Chair of the QI & Research Committee and was elected to a 2-year term on the Executive Committee of the Child Neurology Society in 2021.
Publications
Association of Two Neonatal Encephalopathy Scores with Neurophysiology in Newborns with Suspected Hypoxic Ischemic Encephalopathy. View Abstract
Updates in Neonatal Seizures. View Abstract
Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries. View Abstract
Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States. View Abstract
Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children. View Abstract
Sleep Disorders Five Years After Acute Provoked Neonatal Seizures. View Abstract
Life After Neonatal Seizures: Characterizing the Longitudinal Parent Experience. View Abstract
Practice Variations for Therapeutic Hypothermia in Neonates with Hypoxic-ischemic Encephalopathy: An International Survey. View Abstract
Proceedings of the 15th International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring. View Abstract
The importance of not increasing confusion around neonatal encephalopathy and hypoxic-ischemic encephalopathy. View Abstract
Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series). View Abstract
Establishing a regional registry for neonatal encephalopathy: impact on identification of gaps in practice. View Abstract
Association of cerebral metabolic rate following therapeutic hypothermia with 18-month neurodevelopmental outcomes after neonatal hypoxic ischemic encephalopathy. View Abstract
Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly. View Abstract
Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial. View Abstract
Feeding and developmental outcomes after neonatal seizures-A prospective observational study. View Abstract
Neuroprotective therapies in the NICU in term infants: present and future. View Abstract
Seizure Burden, EEG, and Outcome in Neonates With Acute Intracranial Infections: A Prospective Multicenter Cohort Study. View Abstract
Continuous EEG monitoring still recommended for neonatal seizure management: commentary on NEST trial. View Abstract
Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease. View Abstract
Impact of COVID-19 Pandemic on Developmental Service Delivery in Children With a History of Neonatal Seizures. View Abstract
Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring. View Abstract
Parent Mental Health and Family Coping over Two Years after the Birth of a Child with Acute Neonatal Seizures. View Abstract
Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage. View Abstract
Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study. View Abstract
Treatment of Neonatal Seizures: Comparison of Treatment Pathways From 11 Neonatal Intensive Care Units. View Abstract
Training in neonatal neurocritical care: a proposal for a hybrid model of competence by design and time-based methods. View Abstract
Management of seizures in neonates with neonatal encephalopathy treated with hypothermia. View Abstract
Family-Centered Care for Children and Families Impacted by Neonatal Seizures: Advice From Parents. View Abstract
Early-life epilepsy after acute symptomatic neonatal seizures: A prospective multicenter study. View Abstract
Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures. View Abstract
Seizure Control in Neonates Undergoing Screening vs Confirmatory EEG Monitoring. View Abstract
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. View Abstract
Fetal magnetic resonance imaging: supratentorial brain malformations. View Abstract
Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. View Abstract
Predicting Autism Spectrum Disorder in Very Preterm Infants. View Abstract
Characterization of Death in Infants With Neonatal Seizures. View Abstract
Parent experience of caring for neonates with seizures. View Abstract
Associations between Infant and Parent Characteristics and Measures of Family Well-Being in Neonates with Seizures: A Cohort Study. View Abstract
Early exit from neonatal therapeutic hypothermia: A single institution experience using MRI to guide decision-making. View Abstract
Neonatal seizures: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. View Abstract
Expanding the phenotypic spectrum of Mabry Syndrome with novel PIGO gene variants associated with hyperphosphatasia, intractable epilepsy, and complex gastrointestinal and urogenital malformations. View Abstract
Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. View Abstract
Seizure Prediction Models in the Neonatal Intensive Care Unit. View Abstract
Pharmacologic Prevention and Treatment of Neonatal Brain Injury. View Abstract
Correction to: De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. View Abstract
De novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome. View Abstract
Response to antiseizure medications in neonates with acute symptomatic seizures. View Abstract
Monitoring and management of brain hemodynamics and oxygenation. View Abstract
Recommendations for the design of therapeutic trials for neonatal seizures. View Abstract
Advanced diffusion imaging for assessing normal white matter development in neonates and characterizing aberrant development in congenital heart disease. View Abstract
Congenital muscular dystrophy-dystroglycanopathy, type A, featuring bilateral retinal dysplasia and vertical angle kappa. View Abstract
Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. View Abstract
Acute symptomatic seizures in term neonates: Etiologies and treatments. View Abstract
Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease. View Abstract
Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part II: synthesis of the literature and patient management. View Abstract
Imaging features and prognostic factors in fetal and postnatal torcular dural sinus malformations, part I: review of experience at Boston Children's Hospital. View Abstract
Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. View Abstract
The use of phenobarbital and other anti-seizure drugs in newborns. View Abstract
Profile of neonatal epilepsies: Characteristics of a prospective US cohort. View Abstract
Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. View Abstract
Electroencephalographic discontinuity during sevoflurane anesthesia in infants and children. View Abstract
White Matter Volume Predicts Language Development in Congenital Heart Disease. View Abstract
Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study. View Abstract
Corrigendum to "GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease" [Mol. Genet. Metab. 111 (2014) 393-398]. View Abstract
Fellowship Training in the Emerging Fields of Fetal-Neonatal Neurology and Neonatal Neurocritical Care. View Abstract
BRAT1 mutations present with a spectrum of clinical severity. View Abstract
Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study. View Abstract
Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology. View Abstract
Copy number variation plays an important role in clinical epilepsy. View Abstract
Cerebral blood flow velocity and neurodevelopmental outcome in infants undergoing surgery for congenital heart disease. View Abstract
GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease. View Abstract
Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. View Abstract
Near-infrared spectroscopy versus magnetic resonance imaging to study brain perfusion in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. View Abstract
Passive cooling during transport of asphyxiated term newborns. View Abstract
Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. View Abstract
Brain perfusion in asphyxiated newborns treated with therapeutic hypothermia. View Abstract
Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue. View Abstract
Early versus late MRI in asphyxiated newborns treated with hypothermia. View Abstract
Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair. View Abstract
Neurodevelopmental outcome of fetuses referred for ventriculomegaly. View Abstract
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. View Abstract
Elevated cerebral pressure passivity is associated with prematurity-related intracranial hemorrhage. View Abstract
Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. View Abstract
Cerebral hemodynamic changes during intensive care of preterm infants. View Abstract
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. View Abstract
Positive screening for autism in ex-preterm infants: prevalence and risk factors. View Abstract
Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. View Abstract
Current definitions of hypotension do not predict abnormal cranial ultrasound findings in preterm infants. View Abstract
Neurodevelopmental outcome in survivors of periventricular hemorrhagic infarction. View Abstract
Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? View Abstract
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. View Abstract
Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. View Abstract
Patient with novel interstitial deletion of chromosome 3q13.1q13.3 and agenesis of the corpus callosum. View Abstract
Characterizing the shape of anatomical structures with Poisson's equation. View Abstract
Periventricular hemorrhagic infarction: risk factors and neonatal outcome. View Abstract
Ultrasonographic features and severity scoring of periventricular hemorrhagic infarction in relation to risk factors and outcome. View Abstract
The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. View Abstract
Measurement of cortical thickness in 3D brain MRI data: validation of the Laplacian method. View Abstract
Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants. View Abstract
Talairach-based parcellation of neonatal brain magnetic resonance imaging data: validation of a new approach. View Abstract
Video and CD-ROM as a training tool for performing neurologic examinations of 1-year-old children in a multicenter epidemiologic study. View Abstract
Development of visual acuity in children with cerebral visual impairment. View Abstract
Late gestation cerebellar growth is rapid and impeded by premature birth. View Abstract
In vivo visualization of white matter fiber tracts of preterm- and term-infant brains with diffusion tensor magnetic resonance imaging. View Abstract
Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. View Abstract
Hemodilution elevates cerebral blood flow and oxygen metabolism during cardiopulmonary bypass in piglets. View Abstract
CSF removal in infantile posthemorrhagic hydrocephalus results in significant improvement in cerebral hemodynamics. View Abstract
An elliptic PDE approach for shape characterization. View Abstract
Peroneal neuropathy from ankle-foot orthoses. View Abstract
Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult. View Abstract
Cerebral infarction in Menkes' disease. View Abstract
Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. View Abstract
New technologies in pediatric neurology. Near-infrared spectroscopy. View Abstract
Sonographic ventriculography: a new potential use for sonographic contrast agents in neonatal hydrocephalus. View Abstract
Vestibular-contingent voluntary saccades based on cognitive estimates of remembered vestibular information. View Abstract
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