Jay Thiagarajah, MD, PhD
Co-Director Congenital Enteropathy Program; Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition
Assistant Professor of Pediatrics, Harvard Medical School
Image
Jay Thiagarajah, MD, PhD
Co-Director Congenital Enteropathy Program; Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
St. George's University of London
2009
London
England
Residency
Massachusetts General Hospital
2013
Boston
MA
Fellowship
Boston Children's Hospital
2016
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Gastroenterology)
Professional History
Dr. Thiagarajah serves as an expert for the Department of Gastroenterology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.
Publications
SPECTREPlex: an automated, fast, high-resolution enabled approach for multiplexed cyclic imaging and tissue spatial analysis. View Abstract
The Genetic Architecture of Congenital Diarrhea and Enteropathy. View Abstract
Advancing precision care in pregnancy through a treatable fetal findings list. View Abstract
Stretch and Flex: Mechanosensing and Stem Cells. View Abstract
Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution. View Abstract
Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. View Abstract
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. View Abstract
Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease. View Abstract
ViCE: An automated and quantitative program to assess intestinal tissue morphology. View Abstract
A MERFISHing Expedition for Colitis. View Abstract
Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review. View Abstract
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. View Abstract
WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. View Abstract
Modeling the cell biology of monogenetic intestinal epithelial disorders. View Abstract
Holding Back the Tide: Interferon-gamma to the Rescue. View Abstract
Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease. View Abstract
Intermittent Feasting: Dampening Our Gut Immune Spirits. View Abstract
A Roadmap for the Human Gut Cell Atlas. View Abstract
Perspectives of Rare Disease Experts on Newborn Genome Sequencing. View Abstract
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans. View Abstract
Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids. View Abstract
Gasdermin D pore-forming activity is redox-sensitive. View Abstract
The Immune Ghosts of Pandemics Past. View Abstract
The genetics of monogenic intestinal epithelial disorders. View Abstract
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. View Abstract
The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. View Abstract
Disrupting Polarized Trafficking in Intestinal Epithelial Cells: Insights From a Novel Congenital Enteropathy Gene. View Abstract
Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. View Abstract
Pediatric Gastrointestinal Histopathology in Patients With Tetratricopeptide Repeat Domain 7A (TTC7A) Germline Mutations: A Rare Condition Leading to Multiple Intestinal Atresias, Severe Combined Immunodeficiency, and Congenital Enteropathy. View Abstract
Minimally Invasive Image-Guided Gut Transport Function Measurement Probe. View Abstract
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. View Abstract
Pycro-Manager: open-source software for customized and reproducible microscope control. View Abstract
Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. View Abstract
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. View Abstract
NOX1 Regulates Collective and Planktonic Cell Migration: Insights From Patients With Pediatric-Onset IBD and NOX1 Deficiency. View Abstract
IRE1ß negatively regulates IRE1a signaling in response to endoplasmic reticulum stress. View Abstract
A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. View Abstract
Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency. View Abstract
Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. View Abstract
An Intravenous Fish Oil-Based Lipid Emulsion Successfully Treats Intractable Pruritus and Cholestasis in a Patient with Microvillous Inclusion Disease. View Abstract
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. View Abstract
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. View Abstract
Advances in Evaluation of Chronic Diarrhea in Infants. View Abstract
Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. View Abstract
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. View Abstract
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. View Abstract
CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. View Abstract
Secretory diarrhoea: mechanisms and emerging therapies. View Abstract
Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. View Abstract
Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. View Abstract
Discovery and development of antisecretory drugs for treating diarrheal diseases. View Abstract
Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. View Abstract
Chloride channel-targeted therapy for secretory diarrheas. View Abstract
Response to "Diffusion versus convection". View Abstract
Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs. View Abstract
CFTR inhibitors. View Abstract
CFTR inhibitors for treating diarrheal disease. View Abstract
Airway surface liquid depth imaged by surface laser reflectance microscopy. View Abstract
Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. View Abstract
Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. View Abstract
Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. View Abstract
Noninvasive early detection of brain edema in mice by near-infrared light scattering. View Abstract
New drug targets for cholera therapy. View Abstract
Submucosal gland dysfunction as a primary defect in cystic fibrosis. View Abstract
A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. View Abstract
Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor. View Abstract
CFTR pharmacology and its role in intestinal fluid secretion. View Abstract
Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. View Abstract
Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease. View Abstract
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. View Abstract
Progesterone stimulation of fluid absorption by the rat uterine gland. View Abstract
Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. View Abstract
Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by transforming growth factor beta and angiotensin II. View Abstract
Chloride concentration in endosomes measured using a ratioable fluorescent Cl- indicator: evidence for chloride accumulation during acidification. View Abstract
In vivo fluorescence measurement of Na(+) concentration in the pericryptal space of mouse descending colon. View Abstract
Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching. View Abstract
Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts. View Abstract