Mark Daniel Fleming, MD, DPhil
Pathologist-in-Chief; Hematopathology, Department of Pathology
S. Burt Wolbach Professor of Pathology, Harvard Medical School
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Mark Daniel Fleming, MD, DPhil
Pathologist-in-Chief; Hematopathology, Department of Pathology
S. Burt Wolbach Professor of Pathology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Princeton University
1987
Princeton
NJ
Graduate School
DPhil, Organic Chemistry
University of Oxford
1990
Oxford
England
Medical School
Harvard Medical School
1993
Boston
MA
Residency
Brigham and Women's Hospital
1997
Boston
MA
Fellowship
Brigham and Women's Hospital
1997
Boston
MA
Certifications
American Board of Pathology (Anatomic Clinical Pathology)
American Board of Pathology (Anatomic Hematopathology)
Professional History
Dr. Mark Daniel Fleming is a hematopathologist and Boston Children’s Hospital's Pathologist-In-Chief. He specializes diagnosis of cancers of the blood and lymph systems. His research focuses on iron metabolism in the blood. In addition, he is an associate professor of Pathology at Harvard Medical School.
Dr. Fleming serves as an expert for the Department of Pathology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.
Publications
Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases. View Abstract
X-linked sideroblastic anemia in females. View Abstract
Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease. View Abstract
Expanding the Phenotype of DNA Ligase 1 Deficiency: First Report of Macrocytic Sideroblastic Anemia. View Abstract
Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases. View Abstract
Murine models of erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine. View Abstract
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation. View Abstract
Exome copy number variant detection, analysis, and classification in a large cohort of families with undiagnosed rare genetic disease. View Abstract
Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting. View Abstract
Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis. View Abstract
Exome copy number variant detection, analysis and classification in a large cohort of families with undiagnosed rare genetic disease. View Abstract
Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome. View Abstract
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells. View Abstract
Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. View Abstract
Prospective observational pilot study of quantitative light dosimetry in erythropoietic protoporphyria. View Abstract
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. View Abstract
Functional correlation of genome-wide DNA methylation profiles in genetic neurodevelopmental disorders. View Abstract
Association of Shelter-in-Place Hotels With Health Services Use Among People Experiencing Homelessness During the COVID-19 Pandemic. View Abstract
Neutrality, conflict, and structural determinants of health in a Jerusalem emergency department. View Abstract
Defining case management success: a qualitative study of case manager perspectives from a large-scale health and social needs support program. View Abstract
Hematologic complications with age in Shwachman-Diamond syndrome. View Abstract
Hereditary myopathies associated with hematological abnormalities. View Abstract
Association of unbalanced translocation der(1;7) with germline GATA2 mutations. View Abstract
Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders. View Abstract
Prevalence and Predictors of Iron Deficiency in Adolescent and Young Adult Outpatients: Implications for Screening. View Abstract
"Housing Is Health Care": Treating Homelessness in Safety-net Hospitals. View Abstract
Managing the "hot spots": Health care, policing, and the governance of poverty in the US. View Abstract
Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6. View Abstract
A synonymous coding variant that alters ALAS2 splicing and causes X-linked sideroblastic anemia. View Abstract
SLC25A38 congenital sideroblastic anemia: Phenotypes and genotypes of 31 individuals from 24 families, including 11 novel mutations, and a review of the literature. View Abstract
Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy. View Abstract
Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta. View Abstract
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. View Abstract
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection. View Abstract
Social Literacy: Nurses' Contribution Toward the Co-Production of Self-Management. View Abstract
Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model. View Abstract
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. View Abstract
Patient Engagement, Chronic Illness, and the Subject of Health Care Reform. View Abstract
Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria. View Abstract
A study assessing the feasibility of randomization of pediatric and young adult patients between matched unrelated donor bone marrow transplantation and immune-suppressive therapy for newly diagnosed severe aplastic anemia: A joint pilot trial of the North American Pediatric Aplastic Anemia Consortium and the Pediatric Transplantation and Cellular Therapy Consortium. View Abstract
The role of iron in mediating testosterone's effects on erythropoiesis in mice. View Abstract
ITK deficiency presenting as autoimmune lymphoproliferative syndrome. View Abstract
Histologic and Laboratory Characteristics of Symptomatic and Asymptomatic Castleman Disease in the Pediatric Population. View Abstract
Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model. View Abstract
Outcomes Following Inferior Mesenteric Artery Reimplantation During Elective Aortic Aneurysm Surgery. View Abstract
Single-center experience with Indigo aspiration thrombectomy for acute lower limb ischemia. View Abstract
Clinical features and outcomes of patients with Shwachman-Diamond syndrome and myelodysplastic syndrome or acute myeloid leukaemia: a multicentre, retrospective, cohort study. View Abstract
The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.). View Abstract
Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. View Abstract
The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. View Abstract
Predictors of Successful HIV Care Re-engagement Among Persons Poorly Engaged in HIV Care. View Abstract
Hepcidin is not essential for mediating testosterone's effects on erythropoiesis. View Abstract
The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. View Abstract
A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion. View Abstract
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. View Abstract
Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy. View Abstract
The molecular genetics of sideroblastic anemia. View Abstract
Caring for "Super-utilizers": Neoliberal Social Assistance in the Safety-net. View Abstract
Pancreatic lipomatosis in Diamond-Blackfan anemia: The importance of genetic testing in bone marrow failure disorders. View Abstract
The phenotypic spectrum of germline YARS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. View Abstract
Recurrent heteroplasmy for the MT-ATP6 p.Ser148Asn (m.8969G>A) mutation in patients with syndromic congenital sideroblastic anemia of variable clinical severity. View Abstract
Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice. View Abstract
Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency. View Abstract
RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of ß-thalassemia intermedia. View Abstract
Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. View Abstract
UBE2O remodels the proteome during terminal erythroid differentiation. View Abstract
Ringed sideroblasts in ß-thalassemia. View Abstract
Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation. View Abstract
A novel TERC CR4/CR5 domain mutation causes telomere disease via decreased TERT binding. View Abstract
A recurring mutation in the respiratory complex 1 protein NDUFB11 is responsible for a novel form of X-linked sideroblastic anemia. View Abstract
The placenta: the forgotten essential organ of iron transport. View Abstract
Pseudouridine synthase 1 deficient mice, a model for Mitochondrial Myopathy with Sideroblastic Anemia, exhibit muscle morphology and physiology alterations. View Abstract
Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation. View Abstract
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. View Abstract
LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. View Abstract
Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9. View Abstract
The ins and outs of erythroid heme transport. View Abstract
Severe combined immunodeficiency (SCID) presenting with neonatal aplastic anemia. View Abstract
Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of ß-thalassemia intermedia. View Abstract
Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. View Abstract
Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis. View Abstract
Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels. View Abstract
A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis. View Abstract
Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. View Abstract
Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). View Abstract
The genomic landscape of pediatric Ewing sarcoma. View Abstract
Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression. View Abstract
Hereditary xerocytosis revisited. View Abstract
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. View Abstract
Sideroblastic anemia: diagnosis and management. View Abstract
Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. View Abstract
Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches. View Abstract
X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations. View Abstract
Induced pluripotent stem cells with a mitochondrial DNA deletion. View Abstract
The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. View Abstract
A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD). View Abstract
A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2. View Abstract
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. View Abstract
Heme transport and erythropoiesis. View Abstract
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. View Abstract
The IRP1-HIF-2a axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. View Abstract
Identification and characterization of a novel murine allele of Tmprss6. View Abstract
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine ß-thalassemia intermedia. View Abstract
Mitochondrial heme: an exit strategy at last. View Abstract
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. View Abstract
Increased survival with enzalutamide in prostate cancer after chemotherapy. View Abstract
Pathogenesis of Langerhans cell histiocytosis. View Abstract
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. View Abstract
Identifying, understanding and overcoming barriers to medication error reporting in hospitals: a focus group study. View Abstract
QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines. View Abstract
Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances. View Abstract
Design and validation of a high-throughput matrix-assisted laser desorption ionization time-of-flight mass spectrometry method for quantification of hepcidin in human plasma. View Abstract
Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice. View Abstract
A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. View Abstract
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. View Abstract
Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. View Abstract
Description of the development and validation of the Canadian Paediatric Trigger Tool. View Abstract
Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation. View Abstract
Characterization of mitochondrial ferritin-deficient mice. View Abstract
A tincture of hepcidin cures all: the potential for hepcidin therapeutics. View Abstract
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. View Abstract
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. View Abstract
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. View Abstract
Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors. View Abstract
Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. View Abstract
Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. View Abstract
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. View Abstract
SBDS protein expression patterns in the bone marrow. View Abstract
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. View Abstract
Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial. View Abstract
Recurrent BRAF mutations in Langerhans cell histiocytosis. View Abstract
Pathology of the liver in familial hemophagocytic lymphohistiocytosis. View Abstract
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. View Abstract
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. View Abstract
How much do locked screws add to the fixation of "hybrid" plate constructs in osteoporotic bone? View Abstract
High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine. View Abstract
Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. View Abstract
Safety of carotid endarterectomy in patients concurrently on clopidogrel. View Abstract
Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. View Abstract
Histiocytoses View Abstract
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. View Abstract
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. View Abstract
Iron metabolism and sideroblastic anemias View Abstract
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. View Abstract
hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse. View Abstract
Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. View Abstract
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. View Abstract
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). View Abstract
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. View Abstract
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. View Abstract
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1. View Abstract
The regulation of hepcidin and its effects on systemic and cellular iron metabolism. View Abstract
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. View Abstract
Mutations in the serum/glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse fuzzy (fz) hair phenotype. View Abstract
Response: What's in a name? View Abstract
CD4+/CD56+ hematodermic neoplasm ("blastic natural killer cell lymphoma"): neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon. View Abstract
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. View Abstract
X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation. View Abstract
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. View Abstract
Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. View Abstract
Retinal projections to the subcortical visual system in congenic albino and pigmented rats. View Abstract
Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. View Abstract
The Steap proteins are metalloreductases. View Abstract
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. View Abstract
Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. View Abstract
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. View Abstract
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. View Abstract
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. View Abstract
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. View Abstract
A mouse model of juvenile hemochromatosis. View Abstract
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. View Abstract
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. View Abstract
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. View Abstract
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. View Abstract
Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. View Abstract
Patient safety culture measurement and improvement: a "how to" guide. View Abstract
In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. View Abstract
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. View Abstract
SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. View Abstract
Identification of a novel mutation (C321X) in HJV. View Abstract
Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. View Abstract
Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis. View Abstract
Examination of the Bone marrow View Abstract
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. View Abstract
The genetics of inherited sideroblastic anemias. View Abstract
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism.
View Abstract
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. View Abstract
Immortalization and transformation of primary human airway epithelial cells by gene transfer. View Abstract
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. View Abstract
Lymphomas of the breast: primary and secondary involvement. View Abstract
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. View Abstract
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. View Abstract
Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors. View Abstract
Characterization of a murine high-affinity thiamine transporter, Slc19a2. View Abstract
Myelopoiesis in the zebrafish, Danio rerio. View Abstract
Organized sports for children and preadolescents. View Abstract
The spleen as a diagnostic specimen: a review of 10 years' experience at two tertiary care institutions. View Abstract
A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. View Abstract
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. View Abstract
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. View Abstract
The liver and iron View Abstract
The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. View Abstract
The molecular defect in hypotransferrinemic mice. View Abstract
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. View Abstract
Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption. View Abstract
The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. View Abstract
Iron transport across biologic membranes. View Abstract
Molecular insights into mechanisms of iron transport. View Abstract
Iron and erythropoiesis: Lessons from anemic mice View Abstract
Ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption [commentary] View Abstract
Mammalian iron transport: an unexpected link between metal homeostasis and host defense. View Abstract
Splenic pathology in myelodysplasia: a report of 13 cases with clinical correlation. View Abstract
The G185R mutation disrupts function of the iron transporter Nramp2. View Abstract
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. View Abstract
Hepatic iron overload in the age of hereditary hemochromatosis mutation analysis. View Abstract
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. View Abstract
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.
View Abstract
Absence of dendritic reticulum cell staining is helpful for distinguishing T-cell rish B-cell lymphoma from lymphocyte predominance Hodgkin's Disease View Abstract
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. View Abstract
Angiosarcoma. View Abstract
Iron deficiency anemia associated with an error of iron metabolism in two siblings: A thirty year follow up View Abstract
Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings: A Thirty Year Follow Up. View Abstract
Principles of management of basal and squamous cell carcinoma of the skin. View Abstract
Breast cancer in elderly women. View Abstract
Dominant negative mutants of the transcription factor mXBP-1 View Abstract
Dominant negative mutants of transcription factor mXBP (CRE-BP1, ATF-2). View Abstract
Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response. View Abstract
Studies on the 6-Aminopenicillanic acid, acyl-coenzyme A acyltransferase from P. chrysogenum and A. nidulans View Abstract
Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli. View Abstract
Internal sequence analysis of proteins separated on polyacrylamide gels at the submicrogram level: improved methods, applications and gene cloning strategies. View Abstract
Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans. View Abstract
Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response. View Abstract
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