Suneet Agarwal, MD, PhD
Co-Program Leader for the Stem Cell Transplant Center, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Associate Professor of Pediatrics, Harvard Medical School
Image
Suneet Agarwal, MD, PhD
Co-Program Leader for the Stem Cell Transplant Center, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Harvard Medical School
2001
Boston
MA
Internship
Boston Children's Hospital
2002
Boston
MA
Residency
Pediatrics
Boston Combined Residency Program (BCRP)
2003
Boston
MA
Fellowship
Pediatric Hematology -Oncology
Dana Farber Cancer Institute/Children's Hospital Boston
2006
Boston
MA
Media
Answers Blog
Becca Hudson has dyskeratosis congenita, causing her chromosomes’ telomeres to shorten and her tissues to age too soon. A new treatment that Dr. Suneet Agarwal hopes to test, thymidine, could build telomeres back up.
Certifications
American Board of Pediatrics (Hematology-Oncology)
Publications
ATM-dependent DNA damage response constrains cell growth and drives clonal hematopoiesis in telomere biology disorders. View Abstract
Metabolic constraint of human telomere length by nucleotide salvage efficiency. View Abstract
Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex. View Abstract
Identification of biallelic POLA2 variants in two families with an autosomal recessive telomere biology disorder. View Abstract
Liver disease and transplantation in telomere biology disorders: An international multicenter cohort. View Abstract
Minimal intensity conditioning strategies for bone marrow failure: is it time for "preventative" transplants? View Abstract
Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome. View Abstract
Publisher Correction: Thymidine nucleotide metabolism controls human telomere length. View Abstract
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells. View Abstract
Spectrum of Liver Pathology in Dyskeratosis Congenita. View Abstract
Thymidine nucleotide metabolism controls human telomere length. View Abstract
Domain specific mutations in dyskerin disrupt 3' end processing of scaRNA13. View Abstract
Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6. View Abstract
The clinical and functional effects of TERT variants in myelodysplastic syndrome. View Abstract
Hepatic vascular remodelling in a patient with dyskeratosis congenita. View Abstract
Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis. View Abstract
Mitochondrial function in development and disease. View Abstract
Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome. View Abstract
Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders. View Abstract
Telomerase RNA processing: Implications for human health and disease. View Abstract
Short Telomere Length Predicts Non-Relapse Mortality after Stem Cell Transplantation for Myelodysplastic Syndrome. View Abstract
Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival. View Abstract
Impaired reproductive function and fertility preservation in a woman with a dyskeratosis congenita. View Abstract
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. View Abstract
Understanding the evolving phenotype of vascular complications in telomere biology disorders. View Abstract
Evaluation and Management of Hematopoietic Failure in Dyskeratosis Congenita. View Abstract
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. View Abstract
Exudative Vitreoretinopathy in Dyskeratosis Congenita. View Abstract
Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors. View Abstract
Pulmonary arteriovenous malformations: an uncharacterised phenotype of dyskeratosis congenita and related telomere biology disorders. View Abstract
Retinal findings and a novel TINF2 mutation in Revesz syndrome: Clinical and molecular correlations with pediatric retinal vasculopathies. View Abstract
Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation. View Abstract
A novel TERC CR4/CR5 domain mutation causes telomere disease via decreased TERT binding. View Abstract
Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease. View Abstract
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. View Abstract
Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea. View Abstract
Pearson marrow pancreas syndrome in patients suspected to have Diamond-Blackfan anemia. View Abstract
Induced pluripotent stem cells with a mitochondrial DNA deletion. View Abstract
A young adult with aplastic anemia and gray hair. View Abstract
The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine. View Abstract
CTC1 Mutations in a patient with dyskeratosis congenita. View Abstract
Telomere dynamics in dyskeratosis congenita: the long and the short of iPS. View Abstract
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. View Abstract
Somatic coding mutations in human induced pluripotent stem cells. View Abstract
Cellular therapy for fanconi anemia: the past, present, and future. View Abstract
Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies. View Abstract
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. View Abstract
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. View Abstract
Dynamic instability of genomic methylation patterns in pluripotent stem cells. View Abstract
Reprogramming of T cells from human peripheral blood. View Abstract
AID for reprogramming. View Abstract
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. View Abstract
Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. View Abstract
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. View Abstract
Generation of induced pluripotent stem cells from human blood. View Abstract
Current prospects for the generation of patient-specific pluripotent cells from adult tissues. View Abstract
Cardiac troponin increases among runners in the Boston Marathon. View Abstract
Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. View Abstract
TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells. View Abstract
A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. View Abstract
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. View Abstract
Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. View Abstract
Chromatin-based regulatory mechanisms governing cytokine gene transcription. View Abstract
Regulation of cytokine gene expression during T cell differentiation View Abstract
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. View Abstract
Long-range transcriptional regulation of cytokine gene expression. View Abstract
Genetic-based strategies for control of HIV-1: Tat and Rev as targets.
View Abstract