Alexander McAdam, MD, PHD

Chief, Department of Laboratory Medicine; Medical Director, Infectious Diseases Diagnostic Laboratory

Associate Professor of Pathology, Harvard Medical School

Phone 617-355-5754

Fax 617-730-0383

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NPI 1205847795

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Alexander McAdam, MD, PHD

Chief, Department of Laboratory Medicine; Medical Director, Infectious Diseases Diagnostic Laboratory

Associate Professor of Pathology, Harvard Medical School

Medical Services

Languages

English

Education

Medical School

University of Rochester

1995

Rochester

Internship

Brigham & Women's Hospital

1996

Boston

Residency

Clinical Pathology

Brigham & Women's Hospital

1998

Boston

Certifications

American Board of Pathology (Clinical Pathology)

Professional History

Dr. McAdam received his MD and PhD from the University of Rochester School of Medicine and Dentistry. He completed residency in Clinical Pathology at Brigham and Women’s Hospital, and is board certified in Clinical Pathology by the American Board of Pathology and by the American Board of Medical Microbiology. Dr. McAdam is the Interim Chief of the Department of Laboratory Medicine and has been the Medical Director of the Infectious Diseases Diagnostic Laboratory since 2001. He is an Associate Professor of Pathology at Harvard Medical School.

Dr. McAdam is the Editor-in-Chief of the “Journal of Clinical Microbiology” and an Editor of both the “Manual of Clinical Microbiology” and the forthcoming “Manual of Molecular Microbiology,” all published by the American Society for Microbiology. He is an elected Fellow of the American Academy of Microbiology. Dr. McAdam is Co-Director of the microbiology section for Harvard Medical School and oversees integration of microbiology throughout the medical curriculum as the Theme Faculty for Microbiology. Dr. McAdam’s research is on the utility of diagnostic tests for infectious diseases in children and on evolution of bacteria during chronic infections of humans.

Publications

2024 Acknowledgment of JCM Reviewers. View Abstract

Reaffirming DEI as a central value of JCM. View Abstract

A call for the United States to continue investing in science. View Abstract

2023 Acknowledgment of JCM Reviewers. View Abstract

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen. View Abstract

"Innovative Diagnostic Methods," a new section in the Journal of Clinical Microbiology. View Abstract

The Editors' reply to "Letter responding to performance of updated Enterobacterales piperacillin-tazobactam breakpoints on the MicroScan antimicrobial susceptibility testing system". View Abstract

Antibiotic Therapy for Culture-Proven Bacterial Overgrowth in Children With Intestinal Failure Results in Improved Symptoms and Growth. View Abstract

Clinical Laboratory Budgets during the COVID-19 Pandemic: a Micro-Comic Strip. View Abstract

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections. View Abstract

Cycle Threshold Values from Severe Acute Respiratory Syndrome Coronavirus-2 Reverse Transcription-Polymerase Chain Reaction Assays: Interpretation and Potential Use Cases. View Abstract

Biographical Feature: Andrew B. Onderdonk, Ph.D. View Abstract

Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Children's Hospital and Its Utility in Antimicrobial Stewardship. View Abstract

Fun Classifying Fungal Infections: a Micro-Comic Strip. View Abstract

Too Slow, Less Dough for SARS-CoV-2 Tests? A Micro-Comic Strip. View Abstract

Practice Improvement for Standardized Evaluation and Management of Acute Tracheitis in Mechanically Ventilated Children. View Abstract

Can We Test Our Way Out of the COVID-19 Pandemic? View Abstract

The ASM Journals Committee Values the Contributions of Black Microbiologists. View Abstract

Is This a Critical Result? A Micro-Comic Strip. View Abstract

The ASM Journals Committee Values the Contributions of Black Microbiologists. View Abstract

What Is Needed for the Response to COVID-19? A Micro-Comic Strip. View Abstract

Special Issue on Diagnostic Testing for Severe Acute Respiratory Syndrome Coronavirus 2 and Lessons from This Pandemic. View Abstract

The ASM Journals Committee Values the Contributions of Black Microbiologists. View Abstract

Practical guide for pediatric pulmonologists on imaging management of pediatric patients with COVID-19. View Abstract

The Clinical Microbiology Laboratory Response to COVID-19: a Micro-Comic Strip. View Abstract

What's Special about Cefiderocol? A Micro-Comic Strip. View Abstract

The End of Coagulase-Negative Staphylococci? A Micro-Comic Strip. View Abstract

The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes. View Abstract

Enterobacteriaceae? Enterobacterales? What Should We Call Enteric Gram-Negative Bacilli? A Micro-Comic Strip. View Abstract

Are Bacteria Sensitive or Susceptible? A Micro-Comic Strip. View Abstract

Don't Test Me: a Micro-Comic Strip. View Abstract

Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients. View Abstract

What's That Species? A Micro-Comic Strip. View Abstract

Total Laboratory Automation: a Micro-Comic Strip. View Abstract

What about Serology? A Micro-Comic Strip. View Abstract

Reply to Molitor, "Susceptibility Categories Should Be Agreed Upon". View Abstract

The Photo Quiz: a Look Back and a Look Forward. View Abstract

Improving the Laboratory Information System: a Micro-Comic Strip. View Abstract

Can You Speciate This for Me? A Micro-Comic Strip. View Abstract

What Is the Future of Clinical Microbiology? View Abstract

Epidemiological Cutoff Values: a Micro-Comic Strip. View Abstract

Biographical Feature: Stephen G. Jenkins, Ph.D., D(ABMM), F(AAM). View Abstract

The Significance of Microbial Taxonomy: a Micro-Comic Strip. View Abstract

The Divergent Meanings of "I" for the Clinical and Laboratory Standards Institute and the European Committee on Antimicrobial Susceptibility Testing: a Micro-Comic Strip. View Abstract

Whole-Genome Sequences of Staphylococcus aureus Isolates from Cystic Fibrosis Lung Infections. View Abstract

Rebranding Clinical Laboratories: a Micro-Comic Strip. View Abstract

Pitfalls in Performing Research in the Clinical Microbiology Laboratory: a Micro-Comic Strip. View Abstract

Shotgun Metagenomic Detection of Pathogens: a Micro-Comic Strip. View Abstract

Winners of the American Society for Microbiology Awards in Clinical Microbiology. View Abstract

Paying for Point-of-Care Nucleic Acid Amplification Tests: a Micro-Comic Strip. View Abstract

Total Laboratory Automation in Clinical Microbiology: a Micro-Comic Strip. View Abstract

The Utility of Multiplex Molecular Tests for Enteric Pathogens: a Micro-Comic Strip. View Abstract

The Role of Scientific and Medical Societies in Journals … and More: a Micro-Comic Strip. View Abstract

Ceftaroline pharmacokinetics and pharmacodynamics in patients with cystic fibrosis. View Abstract

Sensitivity and Specificity or Positive and Negative Percent Agreement? A Micro-Comic Strip. View Abstract

Discrepant Analysis and Bias: a Micro-Comic Strip. View Abstract

Prevalence and Predictive Values: a Micro-Comic Strip. View Abstract

Reducing Contamination of Blood Cultures: Consider Costs and Clinical Benefits. View Abstract

Unforeseen Consequences: Culture-Independent Diagnostic Tests and Epidemiologic Tracking of Foodborne Pathogens. View Abstract

Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung. View Abstract

A Rose by Any Other Name: Practical Updates on Microbial Nomenclature for Clinical Microbiology. View Abstract

Association Between Storage Interval and Contamination of Reprocessed Flexible Endoscopes in a Pediatric Gastrointestinal Procedural Unit. View Abstract

ASM Journals Eliminate Impact Factor Information from Journal Websites. View Abstract

The Focus on Quality Publications in Journal of Clinical Microbiology. View Abstract

ASM Journals Eliminate Impact Factor Information from Journal Websites. View Abstract

The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding. View Abstract

Essential Microbiology for Wound Care. View Abstract

ASM Journals Eliminate Impact Factor Information from Journal Websites. View Abstract

Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents. View Abstract

The Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. View Abstract

Closing the Brief Case: Safe To Go Back in the Water? Vibrio parahaemolyticus Wound Infection Associated with Brackish Water. View Abstract

Pediatric Clinical Microbiology: It's the Little Things. View Abstract

Reply to "Case Reports May Be Declared Dead by the Journal of Clinical Microbiology, but They Are Alive and Well in JMM Case Reports". View Abstract

The Brief Case: a New Feature in Journal of Clinical Microbiology. View Abstract

Your Viral Past: A Comprehensive Method for Serological Profiling to Explore the Human Virome. View Abstract

An Obituary for the Case Report in Journal of Clinical Microbiology. View Abstract

The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding. View Abstract

Preface. Diagnostic testing for enteric pathogens. View Abstract

Shiga Toxin Producing Escherichia coli. View Abstract

Point-Counterpoint: Large Multiplex PCR Panels Should Be First-Line Tests for Detection of Respiratory and Intestinal Pathogens. View Abstract

A happy birthday and a transition at the Journal of Clinical Microbiology. View Abstract

What's your subtype? The epidemiologic utility of bacterial whole-genome sequencing. View Abstract

Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. View Abstract

Yield of fungal surveillance cultures in pediatric hematopoietic stem cell transplant patients: a retrospective analysis and survey of current practice. View Abstract

Interferon ?-release assays for diagnosis of latent tuberculosis in healthcare workers in low-incidence settings: pros and cons. View Abstract

Polymerase chain reaction test for Clostridium difficile toxin B gene reveals similar prevalence rates in children with and without inflammatory bowel disease. View Abstract

Biographical feature: Eileen L. Randall, Ph.D. View Abstract

Identifying antibiotic-resistant bacteria in hospitalized patients: what is the role of active-surveillance cultures? View Abstract

Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units. View Abstract

Hand, foot, and mouth disease caused by coxsackievirus a6. View Abstract

John C. Sherris, M.D. View Abstract

Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. View Abstract

Antibiotic resistance: how serious is the problem, and what can be done? View Abstract

Impact of in-hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis. View Abstract

Photo quiz: an 11-year-old with abdominal pain. View Abstract

Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. View Abstract

Molecular testing for infectious diseases should be done in the clinical microbiology laboratory. View Abstract

A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. View Abstract

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes. View Abstract

Improved sensitivity of a commercial reverse transcription-PCR test for subtyping of the 2009 H1N1 influenza A virus. View Abstract

Shiga toxin-producing Escherichia coli in children: diagnosis and clinical manifestations of O157:H7 and non-O157:H7 infection. View Abstract

Streptococcus milleri group pleuropulmonary infection in children: computed tomographic findings and clinical features. View Abstract

Higher prevalence of pharyngeal than nasal Staphylococcus aureus carriage in pediatric intensive care units. View Abstract

Trimethoprim in vitro antibacterial activity is not increased by adding sulfamethoxazole for pediatric Escherichia coli urinary tract infection. View Abstract

Multicenter study of clinical performance of the 3M Rapid Detection RSV test. View Abstract

Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA. View Abstract

Test characteristics of commercial influenza assays for detecting pandemic influenza A (H1N1) in children. View Abstract

Human metapneumovirus. View Abstract

Swine-origin influenza a (H1N1) viral infection in children: initial chest radiographic findings. View Abstract

Respiratory viruses in pediatric and adult populations. Preface. View Abstract

Developments in tissue culture detection of respiratory viruses. View Abstract

Relative impact of influenza and respiratory syncytial virus in young children. View Abstract

Epidemiology and risk factors for Staphylococcus aureus colonization in children in the post-PCV7 era. View Abstract

Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. View Abstract

Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. View Abstract

Influenza and other respiratory virus-related emergency department visits among young children. View Abstract

Validation of syndromic surveillance for respiratory infections. View Abstract

Impact of Burkholderia dolosa on lung function and survival in cystic fibrosis. View Abstract

Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. View Abstract

Pathology of human metapneumovirus infection: insights into the pathogenesis of a newly identified respiratory virus. View Abstract

Human metapneumovirus in children tested at a tertiary-care hospital. View Abstract

Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area. View Abstract

Incidence of outpatient visits and hospitalizations related to influenza in infants and young children. View Abstract

Resistance of group B streptococcus to selected antibiotics, including erythromycin and clindamycin. View Abstract

Human metapneumovirus--an important new respiratory virus. View Abstract

Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. View Abstract

ICOS is critical for CD40-mediated antibody class switching. View Abstract

Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. View Abstract

Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. View Abstract

Discrepant analysis: how can we test a test? View Abstract

B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. View Abstract

Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. View Abstract

Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. View Abstract

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). View Abstract

The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells. View Abstract

IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes. View Abstract

Expression of human prostate-specific antigen (PSA) in a mouse tumor cell line reduces tumorigenicity and elicits PSA-specific cytotoxic T lymphocytes. View Abstract

Analysis of the effect of cytokines (interleukins 2, 3, 4, and 6, granulocyte-monocyte colony-stimulating factor, and interferon-gamma) on generation of primary cytotoxic T lymphocytes against a weakly immunogenic tumor. View Abstract

B7-1 enhances natural killer cell-mediated cytotoxicity and inhibits tumor growth of a poorly immunogenic murine carcinoma. View Abstract

Synergistic effects of co-expression of the TH1 cytokines IL-2 and IFN-gamma on generation of murine tumor-reactive cytotoxic cells. View Abstract

Transfection of transforming growth factor-beta producing tumor EMT6 with interleukin-2 elicits tumor rejection and tumor reactive cytotoxic T-lymphocytes. View Abstract

Isolation and expansion of tumor-infiltrating lymphocytes. View Abstract

Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2. View Abstract

Coexpression of IL-2 and gamma-IFN enhances tumor immunity. View Abstract

Transfection of TGF-beta producing tumors with IL-2 elicits tumor rejection. View Abstract

Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism. View Abstract

CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4+CD8+ cytotoxic T cell clone. View Abstract

Mechanism of cytolytic T lymphocyte killing of a low class I-expressing tumor. View Abstract

Class-I MHC expression in the mouse lung carcinoma, line 1: a model for class-I inducible tumors. View Abstract

Thyroid hormone status regulates preprotachykinin-A gene expression in male rat anterior pituitary. View Abstract

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