Christine Duncan, MD
Senior Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Medical Director of Clinical Research and Clinical Development, Gene Therapy Program, Boston Children’s Hospital
Associate Professor of Pediatrics, Harvard Medical School
Image
Christine Duncan, MD
Senior Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Medical Director of Clinical Research and Clinical Development, Gene Therapy Program, Boston Children’s Hospital
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
University of Chicago Pritzker School of Medicine
1999
Chicago
IL
Media
Parentcast Podcast
Dr. Christine Duncan is featured: Is gene therapy changing pediatric health care?
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Hematology-Oncology)
Publications
Role of Hematopoietic Cell Transplantation in Pediatric and Adult Hemophagocytic Lymphohistiocytosis-Remaining Unknowns and Challenges. View Abstract
Integrating Pulmonary and Systemic Transcriptomic Profiles to Characterize Lung Injury after Pediatric Hematopoietic Stem Cell Transplant. View Abstract
Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation. View Abstract
Bacterial and Parasitic Stool Studies Have Limited Utility in Pediatric Hematopoietic Stem Cell Transplant Patients. View Abstract
Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part III. Long-Term Impact of Chronic Graft-versus-Host Disease on Endocrinologic, Cardiovascular, and Metabolic Outcomes in Survivors of Pediatric Hematopoietic Cell Transplantation. View Abstract
Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part II. Organ Dysfunction and Immune Reconstitution Considerations for Children with Chronic Graft-versus-Host Disease after Hematopoietic Cell Transplantation. View Abstract
Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-Versus-Host Disease Survivorship After Hematopoietic Cell Transplantation: Part IV. Patient Important Outcomes. View Abstract
Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-Versus-Host Disease Survivorship After Hematopoietic Cell Transplantation: Part I. Phases of Chronic GVHD, Supportive Care, and Systemic Therapy Discontinuation. View Abstract
Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy. View Abstract
Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy. View Abstract
Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation. View Abstract
Neurocognitive outcome in children with sickle cell disease after myeloimmunoablative conditioning and haploidentical hematopoietic stem cell transplantation: a non-randomized clinical trial. View Abstract
The Adverse Event Landscape of Stem Cell Transplant: Evidence for AGVHD Driving Early Transplant Associated Toxicities. View Abstract
Characterization of orofacial features in sclerodermatous chronic graft-versus-host disease. View Abstract
Pediatric transplant-associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy. View Abstract
Outcomes for Pediatric Oncology and Hematopoietic Stem Cell Transplantation Patients Who Undergo Tracheostomy Placement: A Pediatric Health Information System Database Cohort Study, 2009-2020. View Abstract
International recommendations for screening and preventative practices for long-term survivors of transplantation and cellular therapy: a 2023 update. View Abstract
International Recommendations for Screening and Preventative Practices for Long-Term Survivors of Transplantation and Cellular Therapy: A 2023 Update. View Abstract
Intensive care risk and long-term outcomes in pediatric allogeneic hematopoietic cell transplant recipients. View Abstract
Overlap chronic GVHD is associated with adverse survival outcomes compared to classic chronic GVHD. View Abstract
Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patients. View Abstract
Monte Carlo based dosimetry of extraoral photobiomodulation for prevention of oral mucositis. View Abstract
Survivors of Pediatric Hematopoietic Stem Cell Transplantation Exhibit Progressive Diastolic Dysfunction Over Years of Follow-Up. View Abstract
Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events. View Abstract
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. View Abstract
Critical Illness Risk and Long-Term Outcomes Following Intensive Care in Pediatric Hematopoietic Cell Transplant Recipients. View Abstract
Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT. View Abstract
Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy. View Abstract
Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome. View Abstract
Gene Therapy for Pediatric Neurologic Disease. View Abstract
Comparison of Pulmonary Toxicity after Total Body Irradiation- and Busulfan-Based Myeloablative Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients. View Abstract
Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation. View Abstract
A biomarker panel for risk of early respiratory failure following hematopoietic cell transplantation. View Abstract
Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy. View Abstract
Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network's Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup. View Abstract
Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation. View Abstract
Extracorporeal membrane oxygenation in children receiving haematopoietic cell transplantation and immune effector cell therapy: an international and multidisciplinary consensus statement. View Abstract
Validation of a Monte Carlo Modelling Based Dosimetry of Extraoral Photobiomodulation. View Abstract
Antigen-specific T cell responses correlate with decreased occurrence of acute GVHD in a multicenter contemporary cohort. View Abstract
Low frequency of treatable pediatric disease alleles in gnomAD: An opportunity for future genomic screening of newborns. View Abstract
Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. View Abstract
The Path to an Evidence-Based Treatment Protocol for Extraoral Photobiomodulation Therapy for the Prevention of Oral Mucositis. View Abstract
Author Correction: Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. View Abstract
Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study. View Abstract
Veno-occlusive disease risk in pediatric patients with acute myeloid leukemia treated with gemtuzumab ozogamicin before allogeneic hematopoietic cell transplantation. View Abstract
Safety of Surgical Fertility Preservation Procedures in Children Prior to Hematopoietic Stem Cell Transplant. View Abstract
Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. View Abstract
Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis. View Abstract
Beyond the storm - subacute toxicities and late effects in children receiving CAR T cells. View Abstract
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD. View Abstract
A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant. View Abstract
The Changing Face of Adrenoleukodystrophy. View Abstract
Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. View Abstract
The Impact of Donor Type on Outcomes and Cost of Allogeneic Hematopoietic Cell Transplantation for Pediatric Leukemia: A Merged Center for International Blood and Marrow Transplant Research and Pediatric Health Information System Analysis. View Abstract
Subsequent neoplasms and late mortality in children undergoing allogeneic transplantation for nonmalignant diseases. View Abstract
Respiratory pathogens associated with intubated pediatric patients following hematopoietic cell transplant. View Abstract
Assessment of ST2 for risk of death following graft-versus-host disease in pediatric and adult age groups. View Abstract
Correction to: Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study. View Abstract
Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. View Abstract
Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. View Abstract
Acute respiratory failure and the kinetics of neutrophil recovery in pediatric hematopoietic cell transplantation: a multicenter study. View Abstract
Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children. View Abstract
Sun exposure and protection practices in children after allogeneic hematopoietic stem cell transplantation: A Survey-Based Cross-Sectional Cohort Study. View Abstract
Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. View Abstract
Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. View Abstract
Severe, persistent neurotoxicity after transplant-associated thrombotic microangiopathy in a pediatric patient despite treatment with eculizumab. View Abstract
Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. View Abstract
Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. View Abstract
Ruxolitinib is an effective steroid sparing agent in children with steroid refractory/dependent bronchiolitis obliterans syndrome after allogenic hematopoietic cell transplantation. View Abstract
Thrombotic Microangiopathy Following Pediatric Autologous Hematopoietic Cell Transplantation: A Report of Significant End-Organ Dysfunction in Eculizumab-Treated Survivors. View Abstract
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. View Abstract
Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. View Abstract
Acute Respiratory Failure in Pediatric Hematopoietic Cell Transplantation: A Multicenter Study. View Abstract
Late Effects Screening Guidelines after Hematopoietic Cell Transplantation (HCT) for Hemoglobinopathy: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. View Abstract
Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children. View Abstract
Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation. View Abstract
Gene Therapy for Cerebral Adrenoleukodystrophy. View Abstract
High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient. View Abstract
Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. View Abstract
Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy. View Abstract
Young Female Donors Do Not Increase the Risk of Graft-versus-Host Disease or Impact Overall Outcomes in Pediatric HLA-Matched Sibling Hematopoietic Stem Cell Transplantation. View Abstract
Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 3: Focus on Cardiorespiratory Dysfunction, Infections, Liver Dysfunction, and Delirium. View Abstract
Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2-Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues. View Abstract
Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment. View Abstract
Late Effects Screening Guidelines after Hematopoietic Cell Transplantation for Inherited Bone Marrow Failure Syndromes: Consensus Statement From the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects After Pediatric HCT. View Abstract
Recommendations for Screening and Management of Late Effects in Patients with Severe Combined Immunodeficiency after Allogenic Hematopoietic Cell Transplantation: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. View Abstract
Survival and Late Effects after Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancy at Less than Three Years of Age. View Abstract
Risk of melanocytic nevi and nonmelanoma skin cancer in children after allogeneic hematopoietic stem cell transplantation. View Abstract
Pediatric Acute Respiratory Distress Syndrome in Pediatric Allogeneic Hematopoietic Stem Cell Transplants: A Multicenter Study. View Abstract
Current Knowledge and Priorities for Future Research in Late Effects after Hematopoietic Cell Transplantation for Inherited Bone Marrow Failure Syndromes: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation. View Abstract
Current Knowledge and Priorities for Future Research in Late Effects after Hematopoietic Stem Cell Transplantation (HCT) for Severe Combined Immunodeficiency Patients: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric HCT. View Abstract
Current Results and Future Research Priorities in Late Effects after Hematopoietic Stem Cell Transplantation for Children with Sickle Cell Disease and Thalassemia: A Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric Hematopoietic Stem Cell Transplantation. View Abstract
Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure. View Abstract
The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell Transplantation for Immune Deficiencies, Inherited Marrow Failure Disorders, and Hemoglobinopathies. View Abstract
National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report. View Abstract
Metabolic syndrome and cardiovascular disease following hematopoietic cell transplantation: screening and preventive practice recommendations from CIBMTR and EBMT. View Abstract
High Variability in the Reported Management of Hepatic Veno-Occlusive Disease in Children after Hematopoietic Stem Cell Transplantation. View Abstract
Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. View Abstract
Metabolic Syndrome and Cardiovascular Disease after Hematopoietic Cell Transplantation: Screening and Preventive Practice Recommendations from the CIBMTR and EBMT. View Abstract
Performance of manual hyperinflation: consistency and modification of the technique by intensive care unit nurses during physiotherapy. View Abstract
Invasive Mechanical Ventilation and Mortality in Pediatric Hematopoietic Stem Cell Transplantation: A Multicenter Study. View Abstract
A Feasibility Study Evaluating Extraoral Photobiomodulation Therapy for Prevention of Mucositis in Pediatric Hematopoietic Cell Transplantation. View Abstract
Use and Effectiveness of Gonadotropin-Releasing Hormone Agonists for Prophylactic Menstrual Suppression in Postmenarchal Women Who Undergo Hematopoietic Cell Transplantation. View Abstract
Pediatric hematopoietic cell transplantation. View Abstract
Secondary solid cancer screening following hematopoietic cell transplantation. View Abstract
Incidence and causes of hospital readmission in pediatric patients after hematopoietic cell transplantation. View Abstract
Bone marrow engraftment and associated dermatologic sequelae in a three-yr-old after liver transplantation. View Abstract
Opportunities and challenges of proteomics in pediatric patients: circulating biomarkers after hematopoietic stem cell transplantation as a successful example. View Abstract
Long-term survival and late effects among one-year survivors of second allogeneic hematopoietic cell transplantation for relapsed acute leukemia and myelodysplastic syndromes. View Abstract
Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children. View Abstract
Second solid cancers after allogeneic hematopoietic cell transplantation using reduced-intensity conditioning. View Abstract
Bleomycin and pulmonary screening: many questions, few answers. View Abstract
Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study. View Abstract
Hematopoietic stem cell transplantation in the leukodystrophies: a systematic review of the literature. View Abstract
Hematopoietic stem cell transplantation in the leukodystrophies: a systematic review of the literature. View Abstract
Yield of fungal surveillance cultures in pediatric hematopoietic stem cell transplant patients: a retrospective analysis and survey of current practice. View Abstract
The effect of an acidic cleanser versus soap on the skin pH and micro-flora of adult patients: a non-randomised two group crossover study in an intensive care unit. View Abstract
Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. View Abstract
Hematopoietic stem cell transplantation in unique pediatric populations: adolescents, infants, and children with down syndrome. View Abstract
How we treat oral chronic graft-versus-host disease. View Abstract
Late effects in hematopoietic cell transplant recipients with acquired severe aplastic anemia: a report from the late effects working committee of the center for international blood and marrow transplant research. View Abstract
Important drug interactions in hematopoietic stem cell transplantation: what every physician should know. View Abstract
Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. View Abstract
25-hydroxy vitamin D deficiency following pediatric hematopoietic stem cell transplant. View Abstract
Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans. View Abstract
Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic graft-versus-host disease (cGVHD). View Abstract
Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. View Abstract
Clinical Outcomes of Adolescent Patients Following Pediatric HSCT View Abstract
Hematology View Abstract
Stem Cell Transplants View Abstract
Relapse Following Busulfan/Cyclophosphamide Conditioning in Children and Adolescents Undergoing HLA-Identical Sibling Transplantion for Stable Phase Chronic Myeloid Leukemia View Abstract
Fasciitis as a Manifestation of Chronic Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Childrens and Adolescents: A Single Institution Experience View Abstract
Chest Radiograph Versus Computed Tomography in the Diagnosis of Acute Pulmonary Complications in Pediatric Stem Cell Transplant View Abstract
Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. View Abstract
The Boston Marathon Study: a novel approach to research during residency. View Abstract
Hyponatremia among runners in the Boston Marathon. View Abstract
Immunizations, neonatal jaundice, and animal-induced injuries. View Abstract
Retroperitoneal abscess and mycotic aortic aneurysm: unusual septic complications of central vascular line placement in premature infants. View Abstract
Herpes simplex virus-associated recurrent erythema multiforme View Abstract
Medical savings accounts: part of the solution View Abstract
Oxidation of hydroxylamine by cytochrome P-460 of the obligate methylotroph Methylococcus capsulatus Bath. View Abstract