Daphne Haas-Kogan, MD
Chief, Department of Radiation Oncology
Professor of Radiation Oncology, Harvard Medical School
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Daphne Haas-Kogan, MD
Chief, Department of Radiation Oncology
Professor of Radiation Oncology, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
University of California, San Francisco
1991
San Francisco
CA
Residency
Radiation Oncology
University of California, San Francisco
1997
Boston
MA
Fellowship
Research
University of California, San Francisco, Diller Family Comprehensive Cancer Center
1994
San Francisco
MA
Certifications
American Board of Radiology (Radiation Oncology)
Professional History
Dr. Haas-Kogan received her medical degree from the University of California at San Francisco (UCSF) in 1991. She completed a research fellowship, followed by residency in radiation oncology at the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC). She spent 18 years as a radiation oncologist, researcher and academic leader in the UCSF HDFCCC system before becoming Chair of the Department of Radiation Oncology at Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Boston Children’s Hospital in 2015.
Publications
Abscopal response in a patient with fibrolamellar hepatocellular carcinoma following radiotherapy. View Abstract
Impact of brain metastasis size at the time of radiotherapy on local control and radiation necrosis. View Abstract
Treatment Approach for Metastatic Intracranial Germinoma: A Multi-Institutional Experience. View Abstract
The association between postoperative photon radiotherapy dose and disease control and salvage treatment in pediatric and adolescent ependymoma: a multi-institutional investigation. View Abstract
Hypofractionated Palliative Radiotherapy for Relapsed and Refractory High-Risk Neuroblastoma. View Abstract
Re-Irradiation Plus Pembrolizumab: A Phase II Study for Patients with Recurrent Glioblastoma. View Abstract
PD-L1, Tumor Mutational Burden, and Outcomes in NSCLC With Brain Metastases: A Brief Report. View Abstract
Multimodal deep learning improves recurrence risk prediction in pediatric low-grade gliomas. View Abstract
Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology Consensus Review on diagnosis, management, and future directions. View Abstract
Leptomeningeal metastatic disease: new frontiers and future directions. View Abstract
Editor's Note: BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. View Abstract
Intracranial outcomes following neurosurgical resection in patients with brain metastases secondary to HER2-positive breast cancer versus other subtypes. View Abstract
When Best Care Takes a Back Seat to the Bottom Line. View Abstract
Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial. View Abstract
DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology. View Abstract
NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy. View Abstract
Stepwise Transfer Learning for Expert-level Pediatric Brain Tumor MRI Segmentation in a Limited Data Scenario. View Abstract
Longitudinal risk prediction for pediatric glioma with temporal deep learning. View Abstract
Patterns of recurrence after radiotherapy for high-risk neuroblastoma: Implications for radiation dose and field. View Abstract
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma. View Abstract
Case Report: Low-grade glioma with NF1 loss of function mimicking diffuse intrinsic pontine glioma. View Abstract
Noninvasive Molecular Subtyping of Pediatric Low-Grade Glioma with Self-Supervised Transfer Learning. View Abstract
Vorinostat, temozolomide or bevacizumab with irradiation and maintenance BEV/TMZ in pediatric high-grade glioma: A Children's Oncology Group Study. View Abstract
A Multi-Institutional Survey of Radiation Oncology Professionals' Knowledge, Attitudes, and Practice Behaviors Toward Sexual and Gender Minority Patients With Cancer. View Abstract
Aurora Kinase A inhibition enhances DNA damage and tumor cell death with 131I-MIBG therapy in high-risk neuroblastoma. View Abstract
Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial. View Abstract
Noninvasive molecular subtyping of pediatric low-grade glioma with self-supervised transfer learning. View Abstract
Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial. View Abstract
Automated temporalis muscle quantification and growth charts for children through adulthood. View Abstract
Re-irradiation of recurrent IDH-wildtype glioblastoma in the bevacizumab and immunotherapy era: Target delineation, outcomes and patterns of recurrence. View Abstract
Genetic architecture of the acute and persistent immune cell response after radiation exposure. View Abstract
A genomic score to predict local control among patients with brain metastases managed with radiation. View Abstract
Expert-level pediatric brain tumor segmentation in a limited data scenario with stepwise transfer learning. View Abstract
Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization. View Abstract
Radiotherapy for Primary Pediatric Central Nervous System Malignancies: Current Treatment Paradigms and Future Directions. View Abstract
Clinical outcomes of radiation therapy for transgender and gender-expansive people with cancer. View Abstract
Children's Oncology Group's 2023 blueprint for research: Central nervous system tumors. View Abstract
Children's Oncology Group's 2023 blueprint for research: Radiation oncology. View Abstract
Multi-institutional Characterization of Outcomes for Pediatric and Young Adult Patients With High-Risk Myxopapillary Ependymoma After Radiation Therapy. View Abstract
Serum miRNA-based signature indicates radiation exposure and dose in humans: A multicenter diagnostic biomarker study. View Abstract
Phase I study of a novel glioblastoma radiation therapy schedule exploiting cell-state plasticity. View Abstract
Incidence proportion and prognosis of leptomeningeal disease among patients with breast vs. non-breast primaries. View Abstract
Feasibility of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) System for Anesthesia Avoidance in Pediatric Patients: A Multicenter Trial. View Abstract
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era. View Abstract
Modulation of Radiation Biomarkers in a Randomized Phase II Study of 131I-MIBG With or Without Radiation Sensitizers for Relapsed or Refractory Neuroblastoma. View Abstract
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. View Abstract
Trends in location of death for individuals with primary brain tumors in the United States. View Abstract
Clinical outcomes and considerations of gender-affirming care for transgender and gender-diverse pediatric and young adult patients with cancer. View Abstract
Wee1 kinase inhibitor adavosertib with radiation in newly diagnosed diffuse intrinsic pontine glioma: A Children's Oncology Group phase I consortium study. View Abstract
DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis. View Abstract
"Per protocol" practice patterns for Children's Oncology Group trials within the radiation oncology community. View Abstract
Predictors of long-term survival among patients with brain metastases. View Abstract
Patient specific distortion detection and mitigation in MR images used for stereotactic radiosurgery. View Abstract
Breast and Cervical Cancer Screening Disparities in Transgender People. View Abstract
Peripheral Blood Transcript Signatures after Internal 131I-mIBG Therapy in Relapsed and Refractory Neuroblastoma Patients Identifies Early and Late Biomarkers of Internal 131I Exposures. View Abstract
A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors. View Abstract
Gender, Productivity, and Philanthropic Fundraising in Academic Oncology. View Abstract
Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas. View Abstract
Frequency, etiologies, risk factors, and sequelae of falls among patients with brain metastases: A population- and institutional-level analysis. View Abstract
Update on Radiation Therapy for Central Nervous System Tumors. View Abstract
Anatomic patterns of relapse and progression following treatment with 131 I-MIBG in relapsed or refractory neuroblastoma. View Abstract
Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases. View Abstract
Harnessing Lactate Metabolism for Radiosensitization. View Abstract
Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From NANT Consortium. View Abstract
Emergency department visits and inpatient hospitalizations among older patients with brain metastases: a dual population- and institution-level analysis. View Abstract
Population-based estimates of survival among elderly patients with brain metastases. View Abstract
Long-term outcomes of pediatric and young adult patients receiving radiotherapy for nonmalignant vascular anomalies. View Abstract
Intracerebral haemorrhage in patients with brain metastases receiving therapeutic anticoagulation. View Abstract
Assessment of Simulated SARS-CoV-2 Infection and Mortality Risk Associated With Radiation Therapy Among Patients in 8 Randomized Clinical Trials. View Abstract
Seizures Among Patients With Brain Metastases: A Population- and Institutional-Level Analysis. View Abstract
Outcomes after first relapse of childhood intracranial ependymoma. View Abstract
Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles. View Abstract
Clinical Characteristics, Experiences, and Outcomes of Transgender Patients With Cancer. View Abstract
Hospice Utilization in Elderly Patients With Brain Metastases. View Abstract
Stereotactic Body Radiation Therapy for Metastatic and Recurrent Solid Tumors in Children and Young Adults. View Abstract
Prostate Cancer Screening Patterns Among Sexual and Gender Minority Individuals. View Abstract
A Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma. View Abstract
Utility of claims data for delineation of intracranial treatment among patients with brain metastases. View Abstract
Reirradiation practices for children with diffuse intrinsic pontine glioma. View Abstract
What HIV/AIDS Taught Me About Pandemics: A Clinician's Perspective. View Abstract
Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy. View Abstract
Racial disparities in supportive medication use among older patients with brain metastases: a population-based analysis. View Abstract
Gliomas, germ cell tumors, and craniopharyngioma. View Abstract
Response rate and local recurrence after concurrent immune checkpoint therapy and radiotherapy for non-small cell lung cancer and melanoma brain metastases. View Abstract
Race Disparities in Proton Radiotherapy Use for Cancer Treatment in Patients Enrolled in Children's Oncology Group Trials. View Abstract
Artificial intelligence in radiation oncology. View Abstract
Practice patterns and recommendations for pediatric image-guided radiotherapy: A Children's Oncology Group report. View Abstract
Feasibility of hippocampal avoidance whole brain radiation in patients with hippocampal involvement: Data from a prospective study. View Abstract
Race Disparities in Proton Radiotherapy Use for Cancer Treatment in Patients Enrolled in Children's Oncology Group Trials. View Abstract
Prospective Evaluation of Radiation Dose Escalation in Patients With High-Risk Neuroblastoma and Gross Residual Disease After Surgery: A Report From the Children's Oncology Group ANBL0532 Study. View Abstract
Treating the SARS-CoV-2-positive patient with cancer: A proposal for a pragmatic and transparent ethical process. View Abstract
Prescription of memantine during non-stereotactic, brain-directed radiation among patients with brain metastases: a population-based study. View Abstract
Mechanisms and therapeutic implications of hypermutation in gliomas. View Abstract
Utility of claims data for identification of date of diagnosis of brain metastases. View Abstract
Phase I Clinical Trial of the Wee1 Inhibitor Adavosertib (AZD1775) with Irinotecan in Children with Relapsed Solid Tumors: A COG Phase I Consortium Report (ADVL1312). View Abstract
Cooperative Blockade of PKCa and JAK2 Drives Apoptosis in Glioblastoma. View Abstract
Revisiting the Role of Radiation Therapy for Pediatric Low-Grade Glioma. View Abstract
Brainstem Injury in Pediatric Patients Receiving Posterior Fossa Photon Radiation. View Abstract
Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial. View Abstract
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. View Abstract
Neuro-Oncology Practice Clinical Debate: targeted therapy vs conventional chemotherapy in pediatric low-grade glioma. View Abstract
A Central Role of Radiation Therapy in Central Nervous System Germinoma. View Abstract
Clinical Impact of Tumor Mutational Burden in Neuroblastoma. View Abstract
Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases. View Abstract
Role of the extent of prophylactic regional lymph node radiotherapy on survival in high-risk neuroblastoma: A report from the COG A3973 study. View Abstract
Moody D. Wharam Jr, MD, FACR, FASTRO, July 22, 1941-August 10, 2018. View Abstract
Towards a standard of care in oncology for transgender patients. View Abstract
Local control after brain-directed radiation in patients with cystic versus solid brain metastases. View Abstract
Management of pediatric low-grade glioma. View Abstract
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. View Abstract
Risk stratification by somatic mutation burden in Ewing sarcoma. View Abstract
Larry Emanuel Kun, March 10, 1946-May 27, 2018. View Abstract
Neurosurgical Resection and Stereotactic Radiation Versus Stereotactic Radiation Alone in Patients with a Single or Solitary Brain Metastasis. View Abstract
Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience. View Abstract
Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. View Abstract
National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. View Abstract
Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint. View Abstract
Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors. View Abstract
The Future of Radiobiology. View Abstract
Phase I study of vorinostat in combination with isotretinoin in patients with refractory/recurrent neuroblastoma: A new approaches to Neuroblastoma Therapy (NANT) trial. View Abstract
The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer. View Abstract
Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation. View Abstract
Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study. View Abstract
Identification of MEK162 as a Radiosensitizer for the Treatment of Glioblastoma. View Abstract
Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways. View Abstract
Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. View Abstract
Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study. View Abstract
Probing the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low-grade gliomas. View Abstract
Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival. View Abstract
Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. View Abstract
A Cautionary Tale: Risks of Radiation Therapy De-Escalation in Pediatric Malignancies. View Abstract
Pediatric low-grade gliomas: implications of the biologic era. View Abstract
Peripheral Blood Biomarkers Associated With Toxicity and Treatment Characteristics After 131I- Metaiodobenzylguanidine Therapy in Patients With Neuroblastoma. View Abstract
Reply to J. Stenman et al. View Abstract
Pediatric high-grade glioma: current molecular landscape and therapeutic approaches. View Abstract
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. View Abstract
Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. View Abstract
Pediatric high-grade glioma: biologically and clinically in need of new thinking. View Abstract
Impact of Extent of Resection on Local Control and Survival in Patients From the COG A3973 Study With High-Risk Neuroblastoma. View Abstract
Patterns of Relapse in High-Risk Neuroblastoma Patients Treated With and Without Total Body Irradiation. View Abstract
Survival after chemotherapy and stem cell transplant followed by delayed craniospinal irradiation is comparable to upfront craniospinal irradiation in pediatric embryonal brain tumor patients. View Abstract
Acute pain management in radiation oncology: Quality of care and the impact of an integrated palliative oncology service. View Abstract
Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. View Abstract
Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth. View Abstract
Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. View Abstract
BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. View Abstract
Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas. View Abstract
Therapeutic radiation and the potential risk of second malignancies. View Abstract
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. View Abstract
Erratum to: Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. View Abstract
Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. View Abstract
Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. View Abstract
WEE1 Kinase As a Target for Cancer Therapy. View Abstract
Medical Student Perspectives on a Multi-institutional Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group. View Abstract
Long-term side effects of radiotherapy for pediatric localized neuroblastoma : results from clinical trials NB90 and NB94. View Abstract
Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. View Abstract
Toward an improved understanding of the ionizing radiation induced DNA damage/response networks in human malignancies. View Abstract
Standardization and quality assurance of radiation therapy volumes for adults with high-grade gliomas. View Abstract
Preface. High-grade gliomas. View Abstract
Pure germinomas of the central nervous system: treatment strategies and outcomes. View Abstract
Non-Muscle Myosin IIa Heavy Chain Links Squamous-Cell Carcinoma of the Head and Neck to the DNA Damage Response. View Abstract
Rates and characteristics of radiographically detected intracerebral cavernous malformations after cranial radiation therapy in pediatric cancer patients. View Abstract
SU-E-T-371: Validation of Organ Doses Delivered During Craniospinal Irradiation with Helical Tomotherapy. View Abstract
Likelihood of bone recurrence in prior sites of metastasis in patients with high-risk neuroblastoma. View Abstract
Quality improvement of International Classification of Diseases, 9th revision, diagnosis coding in radiation oncology: single-institution prospective study at University of California, San Francisco. View Abstract
Oncology scan--Molecular genotyping of medulloblastoma: a new treatment era. View Abstract
In reply to Bull et al. View Abstract
Hyperfractionation: fractious or not? View Abstract
Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) low-grade glioma research workshop. View Abstract
Targeting Wee1 for the treatment of pediatric high-grade gliomas. View Abstract
Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial. View Abstract
The subventricular zone neural progenitor cell hypothesis in glioblastoma: epiphany, Trojan Horse, or Cheshire fact? View Abstract
Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. View Abstract
The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. View Abstract
Risk of first and recurrent stroke in childhood cancer survivors treated with cranial and cervical radiation therapy. View Abstract
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. View Abstract
Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma. View Abstract
Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. View Abstract
Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas. View Abstract
Children's Oncology Group's 2013 blueprint for research: central nervous system tumors. View Abstract
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. View Abstract
Hepatocellular carcinoma: natural history, current management, and emerging tools. View Abstract
PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome. View Abstract
High-grade gliomas in children. View Abstract
The superiority of conservative resection and adjuvant radiation for craniopharyngiomas. View Abstract
Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. View Abstract
Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy. View Abstract
PARP-1 inhibitor MK-4827 in combination with radiation as a treatment strategy for metastatic neuroblastoma. View Abstract
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms. View Abstract
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. View Abstract
Response, survival, and toxicity after iodine-131-metaiodobenzylguanidine therapy for neuroblastoma in preadolescents, adolescents, and adults. View Abstract
DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression. View Abstract
Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. View Abstract
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. View Abstract
MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). View Abstract
Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. View Abstract
Akt and autophagy cooperate to promote survival of drug-resistant glioma. View Abstract
DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. View Abstract
Neoplasms of the hepatobiliary system: clinical presentation, molecular pathways and diagnostics. View Abstract
Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET. View Abstract
Radiation dose estimation using preclinical imaging with I124-metaiodobenzylguanidine (MIBG) PET. View Abstract
Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update. View Abstract
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. View Abstract
Radiation-induced gliomas. View Abstract
Decreased aortic growth and middle aortic syndrome in patients with neuroblastoma after radiation therapy. View Abstract
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival. View Abstract
Successful treatment of high risk and recurrent pediatric desmoids using radiation as a component of multimodality therapy. View Abstract
EGFR signals to mTOR through PKC and independently of Akt in glioma. View Abstract
Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. View Abstract
Outcome of high-risk stage 3 neuroblastoma with myeloablative therapy and 13-cis-retinoic acid: a report from the Children's Oncology Group. View Abstract
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. View Abstract
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. View Abstract
Signal transduction molecules in gliomas of all grades. View Abstract
15-year results for upfront TPDCV chemotherapy phase II trial for pediatric low-grade hypothalamic/chiasmatic gliomas. View Abstract
Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumors. View Abstract
Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. View Abstract
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. View Abstract
PTEN in brain tumors. View Abstract
Glioma invasiveness responds variably to irradiation in a co-culture model. View Abstract
Nutrient-sensitive, antagonistically pleiotropic genes and their contribution to malignant behavior. View Abstract
Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. View Abstract
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. View Abstract
In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas. View Abstract
AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines. View Abstract
Higher radiation dose with a shorter treatment duration improves outcome for locally advanced carcinoma of anal canal. View Abstract
The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs. View Abstract
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. View Abstract
Radiation-induced caspase-8 mediates p53-independent apoptosis in glioma cells. View Abstract
The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas. View Abstract
Clinical outcomes of intraoperative radiation therapy for extremity sarcomas. View Abstract
Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas. View Abstract
Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism. View Abstract
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. View Abstract
Biomarkers to predict response to epidermal growth factor receptor inhibitors. View Abstract
High failure rate in spinal ependymomas with long-term follow-up. View Abstract
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. View Abstract
Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro. View Abstract
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. View Abstract
Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism. View Abstract
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. View Abstract
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. View Abstract
High failure rate in spinal ependymomas with long-term follow-up. View Abstract
Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro. View Abstract
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents. View Abstract
Radiation therapy for intracranial germ cell tumors. View Abstract
Impact of radiotherapy for high-risk neuroblastoma: a Children's Cancer Group study. View Abstract
PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. View Abstract
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival. View Abstract
Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. View Abstract
Functional and clinical outcomes of limb-sparing therapy for pediatric extremity sarcomas. View Abstract
p27Kip1 is required for PTEN-induced G1 growth arrest. View Abstract
Intraoperative radiation therapy for high-risk pediatric neuroblastoma. View Abstract
Loss of PTEN facilitates HIF-1-mediated gene expression. View Abstract
Overexpression of E2F1 in glioma-derived cell lines induces a p53-independent apoptosis that is further enhanced by ionizing radiation. View Abstract
Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells. View Abstract
p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors. View Abstract
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. View Abstract
Ionizing radiation inhibits chemotherapy-induced apoptosis in cultured glioma cells: implications for combined modality therapy. View Abstract
p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma. View Abstract
Cytogenetic damage and the radiation-induced G1-phase checkpoint. View Abstract
P53-independent apoptosis: a mechanism of radiation-induced cell death of glioblastoma cells. View Abstract
Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. View Abstract
Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. View Abstract
Inhibition of apoptosis by the retinoblastoma gene product. View Abstract