I am originally from Belgium where I practiced as a pediatric cardiac anesthesiologist in the department of Pediatric Anesthesiology at Queen Fabiola Children’s University Hospital in Brussels until September 2014. From October 2014 until June 2016, I was a Visiting Assistant Professor of Anaesthesia at Harvard Medical School and Research Associate in the Department of Anesthesiology, Critical Care, and Pain Medicine at Boston Children’s Hospital. I completed my PhD thesis in June 2015, entitled: “Perioperative Management of Bleeding in Children undergoing Cardiac Surgery”.
I then joined the Hospital for Sick Children in 2016 in the Division of Cardiac Anesthesia and the Department of Anesthesia and Pain Medicine and was an Associate Professor of Anesthesia at University of Toronto. I was also Associate Scientist in the Department of Translational Medicine at the Sick Kids Research Institute.
In July 2021, I joined the Arthur S. Keats Division of Pediatric Cardiovascular Anesthesia and Dept. of Anesthesiology, Perioperative and Pain Medicine at Texas Children’s Hospital and was full tenured Professor of Anesthesiology at Baylor College of Medicine. I joined the Division of Cardiac Anesthesia at Boston Children's as a Senior Associate in Cardiac Anesthesia in October 2024.
My research is focused on patient blood management, coagulation, and risk assessment of patients with congenital heart disease.
Publications
Impact of preoperative anemia on hospital costs in children and adolescents undergoing pediatric spinal deformity surgery. View Abstract
Erythrocytes and Platelets Autotransfusion in High Hemorrhagic Risk Cardiac Surgery: A Single-Center Pilot Analysis of the Multicentric SEPIA Registry. View Abstract
Perioperative paediatric patient blood management: a narrative review. View Abstract
Description of the Current Use of Procoagulants in Pediatric Congenital Heart Surgery: An Analysis of the Pediatric Health Information Study Database. View Abstract
Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates. View Abstract
Bivalirudin: The misunderstood alternative to heparin. View Abstract
Retrospective Comparison of Recombinant Activated Factor VII Versus 4-Factor Prothrombin Complex Concentrate in Cardiac Surgical Patients. View Abstract
Higher Cumulative Dose of Opioids and Other Sedatives are Associated with Extubation Failure in Norwood Patients. View Abstract
Cardiac Arrest With or Without Need for Extracorporeal Life Support After Congenital Cardiac Surgery. View Abstract
Development and validation of a multivariable prediction model in pediatric liver transplant patients for predicting intensive care unit length of stay. View Abstract
Perioperative Considerations in Management of the Severely Bleeding Coagulopathic Patient. View Abstract
Secondary impacts of the COVID-19 pandemic at a tertiary children's hospital in Canada: a mixed-methods study. View Abstract
Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care: Second update 2022. View Abstract
Selected 2022 Highlights in Congenital Cardiac Anesthesia. View Abstract
Milrinone therapeutic drug monitoring to reduce low cardiac output syndrome in pediatric patients. View Abstract
FEIBA Use in Neonatal Cardiac Surgery: A Risky Business That Needs Further Investigation. View Abstract
Validation of Automated Data Extraction From the Electronic Medical Record to Provide a Pediatric Risk Assessment Score. View Abstract
Perioperative Considerations for Pediatric Patients With Congenital Heart Disease Presenting for Noncardiac Procedures: A Scientific Statement From the American Heart Association. View Abstract
Commentary: Red blood cells transfusion in patients undergoing congenital cardiac surgery: Still far from physiology-based practice. View Abstract
Tranexamic acid dose-response relationship for antifibrinolysis in postpartum haemorrhage during Caesarean delivery: TRACES, a double-blind, placebo-controlled, multicentre, dose-ranging biomarker study. View Abstract
Recommendations From the International Consensus Conference on Anemia Management in Surgical Patients (ICCAMS). View Abstract
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. View Abstract
Patients With Congenital Heart Disease Undergoing Noncardiac Procedures at Hospitals With and Without a Cardiac Surgical Program. View Abstract
Alternative routes to intravenous tranexamic acid for postpartum hemorrhage: A systematic search and narrative review. View Abstract
Selected 2021 Highlights in Congenital Cardiac Anesthesia. View Abstract
Efficacy and safety of aprotinin in paediatric cardiac surgery: A systematic review and meta-analysis. View Abstract
2021 ELSO Adult and Pediatric Anticoagulation Guidelines. View Abstract
A Global Definition of Patient Blood Management. View Abstract
The Association Between Race and Adverse Postoperative Outcomes in Children With Congenital Heart Disease Undergoing Noncardiac Surgery. View Abstract
The Role of Chronic Conditions in Outcomes following Noncardiac Surgery in Children with Congenital Heart Disease. View Abstract
Trend and Outcomes for Surgical Versus Transcatheter Patent Ductus Arteriosus Closure in Neonates and Infants at US Children's Hospitals. View Abstract
Preoperative Iron Supplementation in Pediatric Cardiac Surgical Patients: A Preliminary Single-Center Experience. View Abstract
Variability in discharge opioid prescribing practices for children: a historical cohort study. View Abstract
Consensus Statement: Hemostasis Trial Outcomes in Cardiac Surgery and Mechanical Support. View Abstract
Development of a preoperative risk score predicting allogeneic red blood cell transfusion in children undergoing spinal fusion. View Abstract
Red Blood Cell Transfusion and Adverse Outcomes in Pediatric Cardiac Surgery Patients: Where Does the Blame Lie? View Abstract
Could we reduce the incidence of immune sensitization prior to heart transplant by reducing exposure to allogeneic blood transfusion? View Abstract
Association Between Intraoperative Remifentanil Dosage and Postoperative Opioid Consumption in Adolescent Idiopathic Spine Surgery: A Retrospective Cohort Study. View Abstract
A Step toward Combined Platelet and Erythrocyte Recovery. View Abstract
Viscoelastic hemostatic assays: Update on technology and clinical applications. View Abstract
Understanding and managing the complex balance between bleeding and thrombosis following cardiopulmonary bypass in paediatric cardiac surgical patients. View Abstract
Effective tranexamic acid concentration for 95% inhibition of tissue-type plasminogen activator-induced hyperfibrinolysis in full-term pregnant women: a prospective interventional study. View Abstract
Predicting Perioperative Respiratory Adverse Events in Children With Sleep-Disordered Breathing. View Abstract
General medical publications during COVID-19 show increased dissemination despite lower validation. View Abstract
Optimal Tranexamic Acid Dosing Regimen in Cardiac Surgery: What Are the Missing Pieces? View Abstract
Trends in mortality rate in patients with congenital heart disease undergoing noncardiac surgical procedures at children's hospitals. View Abstract
Management of Perioperative Iron Deficiency in Cardiac Surgery: A Modified RAND Delphi Study. View Abstract
Comprehensive Risk Assessment of Morbidity in Pediatric Patients Undergoing Noncardiac Surgery: An Institutional Experience. View Abstract
Integration of the Intrinsic Surgical Risk With Patient Comorbidities and Severity of Congenital Cardiac Disease Does Not Improve Risk Stratification in Children Undergoing Noncardiac Surgery. View Abstract
Viscoelastic testing in pediatric patients. View Abstract
Association between preoperative hemoglobin levels after iron supplementation and perioperative blood transfusion requirements in children undergoing scoliosis surgery. View Abstract
Network meta-analysis of isolated patient blood management interventions leads to uncertain interpretation. Comment on Br J Anaesth 2020; https://doi.org/10.1016/j.bja.2020.04.087. View Abstract
Considerations for Pediatric Heart Programs During COVID-19: Recommendations From the Congenital Cardiac Anesthesia Society. View Abstract
Efficacy and safety of decontamination for N95 respirator reuse: a systematic literature search and narrative synthesis. View Abstract
The effect of dexmedetomidine on motor-evoked potentials during pediatric posterior spinal fusion surgery: a retrospective case-control study. View Abstract
Essential Role of Patient Blood Management in a Pandemic: A Call for Action. View Abstract
Commentary: Epsilon-aminocaproic acid versus tranexamic acid, the David and Goliath of antifibrinolytics. View Abstract
Pro: Early Extubation After Pediatric Cardiac Surgery. View Abstract
Commentary: Hepatocellular carcinoma: A threat for patients with Fontan circulation. View Abstract
Tranexamic Acid for Acute Hemorrhage: When Is Enough Evidence Enough? View Abstract
Prospective External Validation of the Pediatric Risk Assessment Score in Predicting Perioperative Mortality in Children Undergoing Noncardiac Surgery. View Abstract
Patient Blood Management in Pediatric Complex Cranial Vault Reconstruction: Time for Some Action. View Abstract
Ischemic limb necrosis in septic shock: What is the role of high-dose vasopressor therapy? View Abstract
Patient Blood Management is not about blood transfusion: it is about patients' outcomes. View Abstract
Association Between Cyanosis, Transfusion, and Thrombotic Complications in Neonates and Children Undergoing Cardiac Surgery. View Abstract
Pediatric Risk Stratification Is Improved by Integrating Both Patient Comorbidities and Intrinsic Surgical Risk. View Abstract
Tranexamic acid and perioperative bleeding in children: what do we still need to know? View Abstract
Preoperative Laboratory Studies for Pediatric Cardiac Surgery Patients: A Multi-Institutional Perspective. View Abstract
Patient Blood Management for Neonates and Children Undergoing Cardiac Surgery: 2019 NATA Guidelines. View Abstract
Sedative and Analgesic Drug Sequestration After a Single Bolus Injection in an Ex Vivo Extracorporeal Membrane Oxygenation Infant Circuit. View Abstract
Recombinant Activated Factor VII in Children Undergoing Cardiac Surgery: Remember How and Why to Use It. View Abstract
Influence of Surgical Procedures and General Anesthesia on Child Development Before Primary School Entry Among Matched Sibling Pairs. View Abstract
Predicting mortality in patients with disseminated intravascular coagulation after cardiopulmonary bypass surgery by utilizing two scoring systems. View Abstract
Traditional and non-traditional anticoagulation management during extracorporeal membrane oxygenation. View Abstract
Preoperative anemia increases the risk of red blood cell transfusion and prolonged hospital length of stay in children undergoing spine arthrodesis surgery. View Abstract
Use of antifibrinolytics in pediatric cardiac surgery: Where are we now? View Abstract
Patient Blood Management in Pediatric Cardiac Surgery: A Review. View Abstract
Use of factor concentrates for the management of perioperative bleeding: reply. View Abstract
Self-reported functional status predicts post-operative outcomes in non-cardiac surgery patients with pulmonary hypertension. View Abstract
Antithrombin Supplementation in Infants Undergoing Cardiac Surgery: A New Piece of a Complex Puzzle. View Abstract
Bivalirudin for Anticoagulation During Cardiopulmonary Bypass in Children With Congenital Heart Disease: Are We Ready Yet? View Abstract
Thromboelastography Is Associated With Surrogates for Bleeding After Pediatric Cardiac Operations. View Abstract
Position of the French Working Group on Perioperative Haemostasis (GIHP) on viscoelastic tests: What role for which indication in bleeding situations? View Abstract
Avoidance of Hyperoxemia during Cardiopulmonary Bypass: Why Does Pathophysiology Not Always Translate into Clinical Outcome? View Abstract
Argatroban and Bivalirudin for Perioperative Anticoagulation in Cardiac Surgery. View Abstract
European guidelines on perioperative venous thromboembolism prophylaxis: Cardiovascular and thoracic surgery. View Abstract
European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery. View Abstract
European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary. View Abstract
Definition of postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass: One size doesn't fit all. View Abstract
Preoperative Thromboelastographic Profile of Patients with Congenital Heart Disease: Association of Hypercoagulability and Decreased Heparin Response. View Abstract
Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH. View Abstract
Incidence and predictors of 30-day postoperative readmission in children. View Abstract
Incidence of non-physiologically complex surgical procedures performed in children: an Ontario population-based study of health administrative data. View Abstract
Elevated preoperative von Willebrand factor is associated with perioperative thrombosis in infants and neonates with congenital heart disease. View Abstract
Use of prothrombin complex concentrate containing heparin for emergency reversal of bivalirudin anticoagulation: a word of caution. View Abstract
Predictors of Mortality in Children with Pulmonary Atresia with Intact Ventricular Septum. View Abstract
Outcomes and Costs of Cardiac Surgery in Adults with Congenital Heart Disease. View Abstract
Reassessing RECESS: In Pursuit of the Golden Ratio of Hemostatic Components to Red Blood Cells. View Abstract
Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology: First update 2016. View Abstract
Incidence and predictors of massive bleeding in children undergoing liver transplantation: A single-center retrospective analysis. View Abstract
Development of a Pediatric Risk Assessment Score to Predict Perioperative Mortality in Children Undergoing Noncardiac Surgery. View Abstract
Recombinant Factor VIIa Is Associated With Increased Thrombotic Complications in Pediatric Cardiac Surgery Patients. View Abstract
Relationship Between Transfusion of Blood Products and the Incidence of Thrombotic Complications in Neonates and Infants Undergoing Cardiac Surgery. View Abstract
The association between the transfusion of small volumes of leucocyte-depleted red blood cells and outcomes in patients undergoing open-heart valve surgery. View Abstract
Association of Preoperative Anemia With Postoperative Mortality in Neonates-Reply. View Abstract
Understanding developmental hemostasis through the use of viscoelastic tests of whole blood coagulation. View Abstract
Tranexamic acid decreases the magnitude of platelet dysfunction in aspirin-free patients undergoing cardiac surgery with cardiopulmonary bypass: a pilot study. View Abstract
Relationship Between Preoperative Anemia and In-Hospital Mortality in Children Undergoing Noncardiac Surgery. View Abstract
Adverse Outcomes in Neonates and Children with Pulmonary Artery Hypertension Supported with ECMO. View Abstract
Randomized controlled trials vs. observational studies: why not just live together? View Abstract
Development and Validation of a Risk Stratification Score for Children With Congenital Heart Disease Undergoing Noncardiac Surgery. View Abstract
Management of direct oral anticoagulants in patients undergoing elective surgeries and invasive procedures: Updated guidelines from the French Working Group on Perioperative Hemostasis (GIHP) - September 2015. View Abstract
Association of Preoperative Anemia With Postoperative Mortality in Neonates. View Abstract
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery. View Abstract
Association of Hospital Structure and Complications With Mortality After Pediatric Extracorporeal Membrane Oxygenation. View Abstract
Incidence and Predictors for Postoperative Thrombotic Complications in Children With Surgical and Nonsurgical Heart Disease. View Abstract
Red Blood Cell Transfusion and Massive Bleeding in Children Undergoing Heart Transplant. View Abstract
Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. View Abstract
Tranexamic Acid Use in United States Children's Hospitals. View Abstract
Heparin Reversal After Cardiopulmonary Bypass: Are Point-of-Care Coagulation Tests Interchangeable? View Abstract
CASE 12-2016 Ascending Aorta Dissection in a Jehovah's Witness Patient on Warfarin. View Abstract
Arterial Limb Microemboli during Cardiopulmonary Bypass: Observations from a Congenital Cardiac Surgery Practice. View Abstract
Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. View Abstract
Impact of advanced monitoring variables on intraoperative clinical decision-making: an international survey. View Abstract
Early thromboelastometry variables predict maximum clot firmness in children undergoing cardiac and non-cardiac surgery. View Abstract
Effective tranexamic acid concentration for 95% inhibition of tissue-type plasminogen activator induced hyperfibrinolysis in children with congenital heart disease: A prospective, controlled, in-vitro study. View Abstract
Hospital Costs for Neonates and Children Supported with Extracorporeal Membrane Oxygenation. View Abstract
Ability of hemostatic assessment to detect bleeding disorders and to predict abnormal surgical blood loss in children: a systematic review and meta-analysis. View Abstract
Quantification of Fibrinolysis Using Velocity Curves Measured with Thromboelastometry in Children with Congenital Heart Disease. View Abstract
Hemoglobin optimization and transfusion strategies in patients undergoing cardiac surgery. View Abstract
Overall Hospital Cost Estimates in Children with Congenital Heart Disease: Analysis of the 2012 Kid's Inpatient Database. View Abstract
Antifibrinolytic Therapy for Cardiac Surgery: An Update. View Abstract
Development of a specific algorithm to guide haemostatic therapy in children undergoing cardiac surgery: a single-centre retrospective study. View Abstract
Fibrinogen concentrate as first-line therapy in children undergoing cardiac surgery: Promising perspectives. View Abstract
Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants. View Abstract
Pre-operative fibrinogen supplementation in cardiac surgery patients. More is not always better. View Abstract
Experimental model of hyperfibrinolysis designed for rotational thromboelastometry in children with congenital heart disease. View Abstract
Efficacy and safety of 6% hydroxyethyl starch 130/0.4 (Voluven) for perioperative volume replacement in children undergoing cardiac surgery: a propensity-matched analysis. View Abstract
Preoperative statins and outcomes after cardiac surgery: do not throw out the baby with the bathwater. View Abstract
CASE 1--2015: left ventricular assist device insertion in a patient with heparin-induced thrombocytopenia and renal failure. View Abstract
Evaluation of dynamic parameters of thrombus formation measured on whole blood using rotational thromboelastometry in children undergoing cardiac surgery: a descriptive study. View Abstract
[Efficacy and safety of tranexamic acid administration for the prevention and/or the treatment of post-partum haemorrhage: a systematic review with meta-analysis]. View Abstract
Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: a randomised, controlled study. View Abstract
Perioperative management of patients receiving new oral anticoagulants: an international survey. View Abstract
No evidence to support a priming strategy with FFP in infants. View Abstract
What's new in management of traumatic coagulopathy? View Abstract
Development of a novel blood-sparing agent in cardiac surgery: do we need another agent? View Abstract
Predictive factors for red blood cell transfusion in children undergoing noncomplex cardiac surgery. View Abstract
Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review. View Abstract
Blood storage duration and morbidity and mortality in children undergoing cardiac surgery. A retrospective analysis. View Abstract
ESA guidelines on the management of severe perioperative bleeding: comments on behalf of the Subcommittee on Transfusion and Haemostasis of the European Association of Cardiothoracic Anaesthesiologists. View Abstract
The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature. View Abstract
Factors affecting postoperative blood loss in children undergoing cardiac surgery. View Abstract
Multivariate model for predicting postoperative blood loss in children undergoing cardiac surgery: a preliminary study. View Abstract
Updates on coagulation management in cardiac surgery. View Abstract
Anaesthesia and orphan disease: a 26-year-old patient with achondroplasia. View Abstract
A systematic review of antifibrinolytics and massive injury. View Abstract
Risks associated with peripherally inserted central catheters. View Abstract
Goal-directed coagulation management in the perioperative period of cardiac surgery. View Abstract
New insights about the use of tranexamic acid in children undergoing cardiac surgery: from pharmacokinetics to pharmacodynamics. View Abstract
Managing new oral anticoagulants in the perioperative and intensive care unit setting. View Abstract
Algorithm-based management of bleeding in patients with extracorporeal membrane oxygenation. View Abstract
An early, multimodal, goal-directed approach of coagulopathy in the bleeding traumatized patient. View Abstract
Perioperative coagulation management in the intensive care unit. View Abstract
Correlation between esCCO and transthoracic echocardiography in critically ill patients. View Abstract
Review of the fibrinolytic system: comparison of different antifibrinolytics used during cardiopulmonary bypass. View Abstract
Editorial: management of perioperative systemic inflammation during cardiopulmonary bypass: we need a multimodal approach. View Abstract
Alternatives to preoperative transfusion should be preferred in anemic cardiac surgical patients instead of useless transfusion. View Abstract
Efficacy of tranexamic acid in paediatric cardiac surgery: a systematic review and meta-analysis. View Abstract
Cough-induced rupture of the right diaphragm and abdominal herniation. View Abstract
Management of the clotting system: a European perspective. View Abstract
Use of tranexamic acid in pediatric cardiac surgery: we really need more. View Abstract
Tranexamic acid could really be recommended in case of subarachnoid hemorrhage? View Abstract
Erythrocyte transfusion: a fair balance. View Abstract
Safety of tranexamic acid in pediatric cardiac surgery: what we do not know. View Abstract
Can we really believe that aprotinin is safe in congenital heart surgery? View Abstract
Does ultrasound guidance improve the efficacy of dorsal penile nerve block in children? View Abstract
Artefact in the electroencephalographic monitoring in a patient with brain metastasis. View Abstract
Routine use of ultrasound to guide internal jugular vein access in children. View Abstract
Different anesthetic techniques associated with different incidences of chronic post-thoracotomy pain: low-dose remifentanil plus presurgical epidural analgesia is preferable to high-dose remifentanil with postsurgical epidural analgesia. View Abstract
Ketamine has no effect on bispectral index during stable propofol-remifentanil anaesthesia. View Abstract