Eva Guinan, MD
Director of Translational Research, Department of Radiation Oncology
Associate Professor of Radiation Oncology, Harvard Medical School
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Eva Guinan, MD
Director of Translational Research, Department of Radiation Oncology
Associate Professor of Radiation Oncology, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Harvard Medical School
1980
Boston
MA
Internship
Boston Children's Hospital
1981
Boston
MA
Residency
Pediatrics
Boston Children's Hospital
1982
Boston
MA
Fellowship
Pediatric Hematology-Oncology
Boston Children's Hospital/Dana-Farber Cancer Institute
1984
Boston
MA
Certifications
American Board of Pediatrics (Hematology-Oncology)
Publications
Allostimulation leads to emergence of a human B cell population with increased expression of HLA class I antigen presentation-associated molecules and the immunoglobulin receptor FcRL5. View Abstract
Health professionals' perceptions of prehabilitation before haematopoietic cell transplantation to optimise candidacy in older adults. View Abstract
Retention rates and reasons for non-retention in exercise oncology trials in the post-treatment phase-a systematic review. View Abstract
Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial. View Abstract
Expanded HCT-CI Definitions Capture Comorbidity Better for Younger Patients of Allogeneic HCT for Nonmalignant Diseases. View Abstract
Physical Therapists in Oncology Settings: Experiences in Delivering Cancer Rehabilitation Services, Barriers to Care, and Service Development Needs. View Abstract
Conservatism Gets Funded? A Field Experiment on the Role of Negative Information in Novel Project Evaluation. View Abstract
Ex vivo generation of regulatory T cells from liver transplant recipients using costimulation blockade. View Abstract
Engineering serendipity: When does knowledge sharing lead to knowledge production? View Abstract
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. View Abstract
Comprehensive Prognostication in Critically Ill Pediatric Hematopoietic Cell Transplant Patients: Results from Merging the Center for International Blood and Marrow Transplant Research (CIBMTR) and Virtual Pediatric Systems (VPS) Registries. View Abstract
Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation. View Abstract
Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting. View Abstract
Alloanergization Method for Inducing Allospecific Hyporesponsiveness in PBMC Exposed to Allostimulation In Vitro in the Context of Costimulatory Molecule Blockade. View Abstract
Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. View Abstract
Toward a more scientific science. View Abstract
The Open Translational Science in Schizophrenia (OPTICS) project: an open-science project bringing together Janssen clinical trial and NIMH data. View Abstract
Infusion of Alloanergized Donor Lymphocytes after CD34-selected Haploidentical Myeloablative Hematopoietic Stem Cell Transplantation. View Abstract
rBPI21 (Opebacan) Promotes Rapid Trilineage Hematopoietic Recovery in a Murine Model of High-Dose Total Body Irradiation. View Abstract
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca-/- and Fancg-/- Mice by Intraoral Administration of GS-Nitroxide (JP4-039). View Abstract
The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration. View Abstract
A Field Experiment on Search Costs and the Formation of Scientific Collaborations. View Abstract
Physical activity and advanced cancer: the views of oncology and palliative care physicians in Ireland. View Abstract
Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis. View Abstract
Three sides to a story: Child, parent, and nurse perspectives on the child's experience during hematopoietic stem cell transplantation. View Abstract
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study. View Abstract
Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study. View Abstract
Ex Vivo Costimulatory Blockade to Generate Regulatory T Cells From Patients Awaiting Kidney Transplantation. View Abstract
Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. View Abstract
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. View Abstract
Looking Across and Looking Beyond the Knowledge Frontier: Intellectual Distance, Novelty, and Resource Allocation in Science. View Abstract
Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation. View Abstract
Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. View Abstract
Parent Outlook: How Parents View the Road Ahead as They Embark on Hematopoietic Stem Cell Transplantation for Their Child. View Abstract
The impact of pediatric blood and marrow transplant on parents: introduction of the parent impact scale. View Abstract
Bone loss and vitamin D deficiency in children undergoing hematopoietic cell transplantation. View Abstract
Changing factors associated with parent activation after pediatric hematopoietic stem cell transplant. View Abstract
Aplastic anemia in adolescents and young adults. View Abstract
Serum citrulline as a biomarker of gastrointestinal function during hematopoietic cell transplantation in children. View Abstract
Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab. View Abstract
Calculating the costs of an 8-week, physiotherapy-led exercise intervention in deconditioned cancer survivors in the early survivorship period (the PEACH trial). View Abstract
Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. View Abstract
Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. View Abstract
Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial. View Abstract
Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. View Abstract
Experiments in Open Innovation at Harvard Medical School: What happens when an elite academic institution starts to rethink how research gets done? View Abstract
The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors--a pilot study. View Abstract
Prize-based contests can provide solutions to computational biology problems. View Abstract
A young adult with aplastic anemia and gray hair. View Abstract
Effect of weight on outcomes of children undergoing hematopoietic cell transplantation. View Abstract
Galactomannan Antigen Testing for Diagnosis of Invasive Aspergillosis in Pediatric Hematology Patients. View Abstract
Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. View Abstract
Attenuation of resting energy expenditure following hematopoietic SCT in children. View Abstract
Effect of titrated parenteral nutrition on body composition after allogeneic hematopoietic stem cell transplantation in children: a double-blind, randomized, multicenter trial. View Abstract
Factors associated with parental activation in pediatric hematopoietic stem cell transplant. View Abstract
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. View Abstract
Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy. View Abstract
17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. View Abstract
Sweet syndrome in patients with Fanconi anaemia: association with extracutaneous manifestations and progression of haematological disease. View Abstract
Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. View Abstract
Outcome of hematopoietic stem cell transplant in children with congenital heart disease. View Abstract
Diagnosis and management of aplastic anemia. View Abstract
Therapy for aplastic anemia. View Abstract
Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. View Abstract
Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. View Abstract
A multi-center, randomized, controlled trial of parenteral nutrition titrated to resting energy expenditure in children undergoing hematopoietic stem cell transplantation ("PNTREE"): rationale and design. View Abstract
Preservation of immune repertoire by selective depletion of haploidentical grafts. View Abstract
Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. View Abstract
Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. View Abstract
Acquired aplastic anemia in childhood. View Abstract
Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. View Abstract
Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. View Abstract
Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. View Abstract
Weekly measurements accurately represent trends in resting energy expenditure in children undergoing hematopoietic stem cell transplantation. View Abstract
Prognostic factors in the resumption of oral dietary intake after allogeneic hematopoietic stem cell transplantation (HSCT) in children. View Abstract
An update on the management of severe idiopathic aplastic anaemia in children. View Abstract
Antigen-specific T-lymphocyte function after cord blood transplantation. View Abstract
A novel pattern of transaminase elevation associated with autologous transplant for neuroblastoma. View Abstract
Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation. View Abstract
Herpes zoster infection in the post-hematopoietic stem cell transplant pediatric population may be preceded by transaminitis: an institutional experience. View Abstract
Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. View Abstract
Antigen-specific T-cell memory is preserved in children treated for acute lymphoblastic leukemia. View Abstract
Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. View Abstract
Protective antibody responses to pneumococcal conjugate vaccine after autologous hematopoietic stem cell transplantation. View Abstract
Contribution of bone marrow-derived endothelial cells to human tumor vasculature. View Abstract
Aplastic anemia: management of pediatric patients. View Abstract
Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients. View Abstract
Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood. View Abstract
Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. View Abstract
Dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature. View Abstract
A multiagent strategy to decrease regimen-related toxicity in children undergoing allogeneic hematopoietic stem cell transplantation. View Abstract
Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. View Abstract
Autoantibodies frequently detected in patients with aplastic anemia. View Abstract
Homozygous alpha-thalassemia treated with intrauterine transfusions and postnatal hematopoietic stem cell transplantation. View Abstract
Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. View Abstract
Waiting for organ transplantation: results of an analysis by an Institute of Medicine Committee. View Abstract
Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. View Abstract
Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. View Abstract
Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome. View Abstract
Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. View Abstract
Marrow failure. View Abstract
Impact of pharmacy practices on the cost of colony-stimulating factor use in pediatric stem cell transplantation: an institution-based analysis. View Abstract
Hepatic veno-occlusive disease following hematopoietic stem cell transplantation. View Abstract
Balancing efficacy with cost: antiemetic control in the pediatric stem cell transplant (SCT) population. View Abstract
The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches. View Abstract
Transplantation of anergic histoincompatible bone marrow allografts. View Abstract
Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired marrow failure syndromes. View Abstract
Comparison of multiple immunization schedules for Haemophilus influenzae type b-conjugate and tetanus toxoid vaccines following bone marrow transplantation. View Abstract
Treatment of severe veno-occlusive disease with defibrotide: compassionate use results in response without significant toxicity in a high-risk population. View Abstract
Subtyping analysis of Fanconi anemia by immunoblotting and retroviral gene transfer. View Abstract
Clinical aspects of aplastic anemia. View Abstract
Bone marrow transplantation for therapy-related myelodysplasia: comparison with primary myelodysplasia. View Abstract
Inducing amenorrhea during bone marrow transplantation. A pilot study of leuprolide acetate. View Abstract
Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. View Abstract
Antibody responses to tetanus toxoid and Haemophilus influenzae type b conjugate vaccines following autologous peripheral blood stem cell transplantation (PBSCT). View Abstract
High-dose cyclophosphamide, carmustine, and etoposide with autologous transplantation in Hodgkin's disease: a prognostic model for treatment outcomes. View Abstract
Measurement of plasma busulfan concentration by high-performance liquid chromatography with ultraviolet detection. View Abstract
Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia. View Abstract
Bone marrow transplantation in sickle cell anemia--the dilemma of choice. View Abstract
Haemophilus influenzae type b (HIB)-conjugate immunization before bone marrow harvest in autologous bone marrow transplantation. View Abstract
Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. View Abstract
Long-term follow-up of 12 pediatric patients with primary myelodysplastic syndrome treated with HLA-identical sibling donor bone marrow transplantation. View Abstract
Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation. View Abstract
Diamond-Blackfan anemia. Natural history and sequelae of treatment. View Abstract
GM-CSF clinical trials: pediatric aplastic anemia and Fanconi's anemia. View Abstract
Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. View Abstract
Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. View Abstract
Polysaccharide conjugate vaccine responses in bone marrow transplant patients. View Abstract
Evaluation of granulocyte-macrophage colony-stimulating factor for treatment of pancytopenia in children with fanconi anemia. View Abstract
In vitro enhancement of erythropoiesis by steel factor in Diamond-Blackfan anemia and treatment of other congenital cytopenias with recombinant interleukin 3/granulocyte-macrophage colony stimulating factor. View Abstract
Prognostic factors for treatment outcome in autotransplantation of intermediate-grade and high-grade non-Hodgkin's lymphoma with cyclophosphamide, carmustine, and etoposide. View Abstract
Effects of interleukin-3 and granulocyte-macrophage colony-stimulating factor on thrombopoiesis in congenital amegakaryocytic thrombocytopenia. View Abstract
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. View Abstract
Bone marrow transplantation for myelodysplasia and secondary acute nonlymphoblastic leukemia. View Abstract
A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia. View Abstract
Renal insufficiency after total body irradiation for pediatric bone marrow transplantation. View Abstract
Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease. View Abstract
Bone marrow transplantation for children with myelodysplastic syndromes. View Abstract
Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. View Abstract
Cytoplasmic transfer between endothelium and lymphocytes: quantitation by flow cytometry. View Abstract
Intravascular hemolysis and renal insufficiency after bone marrow transplantation. View Abstract
Late onset of renal dysfunction in survivors of bone marrow transplantation. View Abstract
Bone marrow transplantation for constitutional pure red cell aplasia. View Abstract
Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor. View Abstract
Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. View Abstract
Efficacy of a cyclophosphamide-procarbazine-antithymocyte serum regimen for prevention of graft rejection following bone marrow transplantation for transfused patients with aplastic anemia. View Abstract