Hans Oettgen, MD, PhD
Deputy Chief, Department of Pediatrics; Associate Chief, Division of Immunology
Prince Turki Bin Abdul Aziz Al-Saud Professor of Pediatrics, Harvard Medical School; Harvard Medical School Faculty Dean for Academic Programs at Boston Children’s Hospital
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Hans Oettgen, MD, PhD
Deputy Chief, Department of Pediatrics; Associate Chief, Division of Immunology
Prince Turki Bin Abdul Aziz Al-Saud Professor of Pediatrics, Harvard Medical School; Harvard Medical School Faculty Dean for Academic Programs at Boston Children’s Hospital
Medical Services
Languages
English
Education
Undergraduate School
Williams College
1980
Williamstown
MA
US
Medical School
Harvard Medical School
1987
Boston
MA
US
Internship
Boston Children's Hospital
1988
Boston
MA
US
Residency
Pediatrics
Boston Children's Hospital
1990
Boston
MA
US
Fellowship
Allergy & Immunology
Boston Children's Hospital
1993
Boston
MA
Certifications
American Board of Allergy & Immunology (General)
Professional History
Dr. Oettgen received his MD and PhD (Immunology) degrees from Harvard Medical School. He completed his clinical training in Pediatrics and in Allergy & Immunology at Boston Children’s Hospital followed by post-doctoral research training in Genetics at Harvard Medical School with Dr. Philip Leder. Dr. Oettgen joined the Children’s Hospital faculty in 1994, providing and care for children with allergic disorders and overseeing a research program on the regulation of allergic responses. He holds the Prince Turki Bin Abdul Aziz Al-Saud Professorship in Pediatrics at Harvard Medical School and serves as Deputy Chief of the Department of Pediatrics, Associate Chief of the Division of Immunology and Harvard Medical School Dean for Academic Programs at Boston Children’s Hospital.
Publications
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. View Abstract
Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy. View Abstract
Rethinking Immunological Risk: A Retrospective Cohort Study of Severe SARS-Cov-2 Infections in Individuals With Congenital Immunodeficiencies. View Abstract
Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies. View Abstract
IgG:Fc?RIIb signals block effector programs of IgE:FceRI-activated mast cells but spare survival pathways. View Abstract
Mast cells in food allergy: Inducing immediate reactions and shaping long-term immunity. View Abstract
Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils. View Abstract
High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy. View Abstract
Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. View Abstract
Mast Cells as Regulators of Adaptive Immune Responses in Food Allergy. View Abstract
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. View Abstract
IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy. View Abstract
Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation. View Abstract
IgE and mast cells: The endogenous adjuvant. View Abstract
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. View Abstract
Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. View Abstract
The soluble isoform of human Fc?RI is an endogenous inhibitor of IgE-mediated mast cell responses. View Abstract
Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies. View Abstract
Tissue-Specific Expression of the Low-Affinity IgG Receptor, Fc?RIIb, on Human Mast Cells. View Abstract
Importance of basophils in eosinophilic asthma: the murine counterpart. View Abstract
IgE promotes type 2 innate lymphoid cells in murine food allergy. View Abstract
Food allergy. View Abstract
Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469. View Abstract
Allergen-specific IgG antibody signaling through Fc?RIIb promotes food tolerance. View Abstract
A humanized mouse model of anaphylactic peanut allergy. View Abstract
Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases. View Abstract
IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. View Abstract
IgE receptor signaling in food allergy pathogenesis. View Abstract
IgE and Mast Cells: The Endogenous Adjuvant. View Abstract
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. View Abstract
Polyclonal IgE Induces Mast Cell Survival and Cytokine Production. View Abstract
Anti-IgE therapy: clinical utility and mechanistic insights. View Abstract
Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. View Abstract
Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. View Abstract
Food allergy: Insights into etiology, prevention, and treatment provided by murine models. View Abstract
Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses. View Abstract
IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum. View Abstract
An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis. View Abstract
A beneficial role for immunoglobulin E in host defense against honeybee venom. View Abstract
Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. View Abstract
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. View Abstract
Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. View Abstract
IL-21 is the primary common ? chain-binding cytokine required for human B-cell differentiation in vivo. View Abstract
Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. View Abstract
Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. View Abstract
High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. View Abstract
Mast cells and tumour necrosis factor alpha (TNF-a): partners in crime in asthma pathogenesis. View Abstract
IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. View Abstract
Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls. View Abstract
Anti-IgE in the treatment of allergic disorders in pediatrics. View Abstract
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. View Abstract
In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. View Abstract
Adaptive immunity. View Abstract
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. View Abstract
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. View Abstract
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. View Abstract
Polyclonal IgE induces mast cell survival and cytokine production. View Abstract
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. View Abstract
Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. View Abstract
Novel presentation of Omenn syndrome in association with aniridia. View Abstract
IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation. View Abstract
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. View Abstract
Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten. View Abstract
Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. View Abstract
Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection. View Abstract
TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation. View Abstract
Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. View Abstract
Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus. View Abstract
The H1 histamine receptor regulates allergic lung responses. View Abstract
The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. View Abstract
TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. View Abstract
COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. View Abstract
Antigen-independent effects of immunoglobulin E. View Abstract
Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production. View Abstract
Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells. View Abstract
The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. View Abstract
Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. View Abstract
Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. View Abstract
IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. View Abstract
Epicutaneous sensitization with superantigen induces allergic skin inflammation. View Abstract
Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. View Abstract
IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. View Abstract
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. View Abstract
Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. View Abstract
CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. View Abstract
Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. View Abstract
Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. View Abstract
Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. View Abstract
IgE regulation and roles in asthma pathogenesis. View Abstract
Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis. View Abstract
An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. View Abstract
Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts. View Abstract
CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. View Abstract
IgE in asthma and atopy: cellular and molecular connections. View Abstract
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. View Abstract
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. View Abstract
Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. View Abstract
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. View Abstract
Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. View Abstract
The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE. View Abstract
A murine model of allergic rhinitis: studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin. View Abstract
IgE regulates mouse basophil Fc epsilon RI expression in vivo. View Abstract
Normal ranges for lymphocyte subsets in children. View Abstract
Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. View Abstract
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. View Abstract
IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. View Abstract
Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni. View Abstract
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. View Abstract
Active anaphylaxis in IgE-deficient mice. View Abstract
GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines. View Abstract
Cytokines in clinical cancer therapy. View Abstract
Human monoclonal antibody with dual GM2/GD2 specificity derived from an immunized melanoma patient. View Abstract
Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. View Abstract
The T-cell receptor-T3 complex and T-lymphocyte activation. View Abstract
A review of the structure and function of the T-cell receptor-T3 complex. View Abstract
Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. View Abstract
A T3-like protein complex associated with the antigen receptor on murine T cells. View Abstract
The T cell receptor/T3 complex. View Abstract
Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: specificity analysis and comparison of antigen expression in cultured cells and tissues. View Abstract
Purification, preliminary characterization, and immunological comparison of hog lens leucine aminopeptidase (EC 3.4.11.1) with hog kidney and beef lens aminopeptidases. View Abstract
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. View Abstract
The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits. View Abstract
The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides. View Abstract
Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. View Abstract
Comparison of leucine aminopeptidase from human lens, beef lens and kidney, and hog lens and kidney. View Abstract
In vivo localization of cloned IL-2-dependent T cells. View Abstract
Further biochemical studies of the human B-cell differentiation antigens B1 and B2. View Abstract
Locations