American Board of Pediatrics (Infectious Diseases)
Professional History
Dr. Moffitt joined the faculty of the Pediatric Infectious Diseases Division at Boston Children’s Hospital upon completion of her fellowship training in 2010. In her last year of fellowship, she received the Kass Award for Excellence in Clinical Care from the Massachusetts Infectious Diseases Society and has since received awards from the Pediatric Infectious Diseases Society and the Charles Hood Foundation to support her research in bacterial vaccine development and immunity to bacterial infections. In addition to caring for patients seen by the Infectious Diseases consult service, Dr. Moffitt devotes her time to studying how bacteria cause disease. Of particular interest is furthering our understanding of how people develop immunity to infection with several common bacteria, such as Staphylococcus aureus. Through several clinical and translational studies, Dr. Moffitt is investigating the role of specific bacterial factors during infection and immune responses in affected patients and hopes that findings from this research will contribute to the development of therapies to prevent and treat such infections.
Approach to Care
The opportunity to contribute to the care and healing of people during a time that is often one of the most challenging of their lives inspired me to become a physician. When faced with a difficult to diagnose illness or an infection that is challenging to treat, every component of a patient’s underlying health and goals of care should be considered, and every patient is unique. As a pediatric infectious diseases provider, I strive to work collaboratively with each patient, family and care team to offer the most comprehensive and patient-centered guidance possible to diagnose, optimally treat, and prevent infections.
Publications
Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care. View Abstract
Molecular mimicry in multisystem inflammatory syndrome in children. View Abstract
Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection. View Abstract
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children. View Abstract
NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. View Abstract
Host Respiratory Transcriptome Signature Associated with Poor Outcome in Children with Influenza-Staphylococcus aureus Pneumonia. View Abstract
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. View Abstract
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. View Abstract
Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections. View Abstract
Process intensification for production of Streptococcus pneumoniae whole-cell vaccine. View Abstract
Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness. View Abstract
Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome. View Abstract
IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. View Abstract
Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency. View Abstract
Rationale and prospects for novel pneumococcal vaccines. View Abstract
T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. View Abstract
Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. View Abstract
Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. View Abstract
Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. View Abstract
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. View Abstract
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. View Abstract
Next generation pneumococcal vaccines. View Abstract
