Leslie Lehmann, MD
Director, Clinical Stem Cell Transplantation Program; Medical Director, International Hematology/Oncology/BMT
Associate Professor, Harvard Medical School
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Leslie Lehmann, MD
Director, Clinical Stem Cell Transplantation Program; Medical Director, International Hematology/Oncology/BMT
Associate Professor, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Duke University School of Medicine
Durham
NC
Residency
Pediatrics
Duke University School of Medicine
Durham
NC
Fellowship
Pediatric Hematology-Oncology
Boston Children's Hospital/Dana-Farber Cancer Institute
Boston
MA
Certifications
American Board of Pediatrics (Hematology-Oncology)
Professional History
Dr. Leslie Lehmann is the clinical director of the Stem Cell Transplantation Program at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. She specializes in bone marrow and stem cell transplantation and the long-term effects of stem cell transplantation. In addition, she is an assistant professor of Pediatrics at Harvard Medical School.
Publications
Multicenter Study on Caregiver Experiences in Pediatric Hematopoietic Stem Cell Transplantation: Part II. Treatment Challenges, Communication Barriers, and Caregiver-Driven Approaches to Mitigation. View Abstract
Multicenter Study on Caregiver Experiences in Pediatric Hematopoietic Stem Cell Transplantation Part I: Integrative Analysis of Mental Health, Psychosocial Stressors, and Support Mechanisms. View Abstract
Community respiratory viruses are generally well-tolerated in hematopoietic stem cell transplant recipients: a brief report from the TRANSPIRE study. View Abstract
Engraft: A Collaborative Learning Health Network for Enhanced Transplant and Cellular Therapy Outcomes. View Abstract
Global health training opportunities during pediatric hematology/oncology fellowship: Results from a survey of program leaders. View Abstract
Quality of life and late therapy effects in pediatric non-Hodgkin lymphoma survivors: Insights from a single-institution study. View Abstract
Induction of remission after donor lymphocyte infusion following allogeneic transplant in a case of pediatric primary myelofibrosis. View Abstract
In Pursuit of Optimal Outcomes: A Framework for Quality Standards in Immune Effector Cell Therapy. View Abstract
Impact of Race and Ethnicity on Outcomes After Umbilical Cord Blood Transplantation. View Abstract
Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities. View Abstract
Navigating Treatment Options and Communication in Relapsed Pediatric AML. View Abstract
Predictive value of early molecular response to tyrosine kinase inhibitors in pediatric patients with chronic myeloid leukemia. View Abstract
Pediatric transplant-associated thrombotic microangiopathy health care utilization and implications of eculizumab therapy. View Abstract
A nursing perspective on inpatient sleep and circadian disruptions for pediatric stem cell transplant patients. View Abstract
Treatment of recurrent pediatric myelodysplastic syndrome post hematopoietic stem cell transplantation. View Abstract
Sleep and circadian disruptors: Unhealthy noise and light levels for hospitalized pediatric patients. View Abstract
Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias. View Abstract
Survivors of Pediatric Hematopoietic Stem Cell Transplantation Exhibit Progressive Diastolic Dysfunction Over Years of Follow-Up. View Abstract
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. View Abstract
Racial and Socioeconomic Disparities in Long-Term Outcomes in =1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis. View Abstract
Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders. View Abstract
Real-world experience with low-dose IL-2 for children and young adults with refractory chronic graft-versus-host disease. View Abstract
Impact of Public Reporting of Center-Specific Survival Analysis Scores on Patient Volumes at Hematopoietic Cell Transplant Centers. View Abstract
Prior COVID-19 infection may increase risk for developing endothelial dysfunction following hematopoietic cell transplantation. View Abstract
An Analysis of the Worldwide Utilization of Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia. View Abstract
Secondary Impact of the Coronavirus Disease 19 Pandemic on Patients and the Cellular Therapy Healthcare Ecosystem. View Abstract
Characteristics, Treatment Complexity, and Outcome of Mixed-Phenotype Acute Leukemia in Children in a Low-Middle-Income Country. View Abstract
A Ten-Year Experience of Treating Chronic Myeloid Leukemia in Rural Rwanda: Outcomes and Insights for a Changing Landscape. View Abstract
Nephroblastoma Treatment and Outcomes in a Low-Income Setting. View Abstract
Comparison of Pulmonary Toxicity after Total Body Irradiation- and Busulfan-Based Myeloablative Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients. View Abstract
Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation. View Abstract
Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation. View Abstract
Candidacy for Extracorporeal Life Support in Children After Hematopoietic Cell Transplantation: A Position Paper From the Pediatric Acute Lung Injury and Sepsis Investigators Network's Hematopoietic Cell Transplant and Cancer Immunotherapy Subgroup. View Abstract
Quality Improvement in Hematopoietic Stem Cell Transplant and Cellular Therapy: Using the Model for Improvement to impact Outcomes. View Abstract
Comparison of toxicity following single versus tandem autologous transplant regimens for pediatric medulloblastoma. View Abstract
MECOM gene overexpression in pediatric patients with acute myeloid leukemia. View Abstract
Extracorporeal Membrane Oxygenation Candidacy in Pediatric Patients Treated With Hematopoietic Stem Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy: An International Survey. View Abstract
Impact of decreasing vancomycin exposure on acute kidney injury in stem cell transplant recipients. View Abstract
Emerging therapeutic and preventive approaches to transplant-associated thrombotic microangiopathy. View Abstract
Low frequency of treatable pediatric disease alleles in gnomAD: An opportunity for future genomic screening of newborns. View Abstract
Playful strategies to foster the well-being of pediatric cancer patients in the Brazilian Unified Health System: a design thinking approach. View Abstract
Author Correction: Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. View Abstract
Safety of Surgical Fertility Preservation Procedures in Children Prior to Hematopoietic Stem Cell Transplant. View Abstract
Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer. View Abstract
Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis. View Abstract
A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant. View Abstract
Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease. View Abstract
Analysis of Time to Complete Response after Defibrotide Initiation in Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. View Abstract
A study assessing the feasibility of randomization of pediatric and young adult patients between matched unrelated donor bone marrow transplantation and immune-suppressive therapy for newly diagnosed severe aplastic anemia: A joint pilot trial of the North American Pediatric Aplastic Anemia Consortium and the Pediatric Transplantation and Cellular Therapy Consortium. View Abstract
Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee. View Abstract
Treatment of Hodgkin Lymphoma With ABVD Chemotherapy in Rural Rwanda: A Model for Cancer Care Delivery Implementation. View Abstract
Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort. View Abstract
Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. View Abstract
Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices. View Abstract
Pooled analysis of Day 100 survival for defibrotide-treated patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome and ventilator or dialysis dependence following haematopoietic cell transplantation. View Abstract
Comparison of Outcomes of Myeloablative Allogeneic Stem Cell Transplantation for Pediatric Patients with Bone Marrow Failure, Myelodysplastic Syndrome and Acute Myeloid Leukemia with and without Germline GATA2 Mutations. View Abstract
Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation. View Abstract
Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position statement. View Abstract
Predictors of Loss to Follow-Up Among Pediatric and Adult Hematopoietic Cell Transplantation Survivors: A Report from the Center for International Blood and Marrow Transplant Research. View Abstract
Incidence, risk factors, and outcome of blood stream infections during the first 100 days post-pediatric allogeneic and autologous hematopoietic stem cell transplantations. View Abstract
Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children. View Abstract
Sun exposure and protection practices in children after allogeneic hematopoietic stem cell transplantation: A Survey-Based Cross-Sectional Cohort Study. View Abstract
Therapeutic Impact and Complications Associated with Surgical Lung Biopsy after Allogeneic Hematopoietic Stem Cell Transplantation in Children. View Abstract
Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. View Abstract
Protecting the Selfless: Toward More Comprehensive Care for Pediatric Related Stem Cell Donors. View Abstract
Severe, persistent neurotoxicity after transplant-associated thrombotic microangiopathy in a pediatric patient despite treatment with eculizumab. View Abstract
Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. View Abstract
Ruxolitinib is an effective steroid sparing agent in children with steroid refractory/dependent bronchiolitis obliterans syndrome after allogenic hematopoietic cell transplantation. View Abstract
Day +100 Platelet Count Predicts Survival After Allogeneic Hematopoietic Stem-Cell Transplantation in Children With Hematologic Malignancies. View Abstract
Thrombotic Microangiopathy Following Pediatric Autologous Hematopoietic Cell Transplantation: A Report of Significant End-Organ Dysfunction in Eculizumab-Treated Survivors. View Abstract
Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy. View Abstract
Outcome of Childhood Acute Megakaryoblastic Leukemia: Children's Cancer Hospital Egypt 57357 Experience. View Abstract
A single institutional review of pediatric Bacillus spp. bloodstream infections demonstrates increased incidence among children with cancer. View Abstract
Implementation of a graduated-intensity approach for acute lymphoblastic leukemia in a Rwandan district hospital. View Abstract
Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. View Abstract
Recommendations on RBC Transfusion Support in Children With Hematologic and Oncologic Diagnoses From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. View Abstract
Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease after Reduced-Intensity Conditioning Allogeneic Transplantation. View Abstract
Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome following nontransplant-associated chemotherapy: Final results from a post hoc analysis of data from an expanded-access program. View Abstract
Final results from a defibrotide treatment-IND study for patients with hepatic veno-occlusive disease/sinusoidal obstruction syndrome. View Abstract
Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children. View Abstract
Donor body mass index does not predict graft versus host disease following hematopoietic cell transplantation. View Abstract
Outcomes of Low-Intensity Treatment of Acute Lymphoblastic Leukemia at Butaro Cancer Center of Excellence in Rwanda. View Abstract
Young Female Donors Do Not Increase the Risk of Graft-versus-Host Disease or Impact Overall Outcomes in Pediatric HLA-Matched Sibling Hematopoietic Stem Cell Transplantation. View Abstract
Strange Bedfellows No More: How Integrated Stem-Cell Transplantation and Palliative Care Programs Can Together Improve End-of-Life Care. View Abstract
Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment. View Abstract
Pretransplant functional imaging and outcome in pediatric patients with relapsed/refractory Hodgkin lymphoma undergoing autologous transplantation. View Abstract
Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. View Abstract
Risk of melanocytic nevi and nonmelanoma skin cancer in children after allogeneic hematopoietic stem cell transplantation. View Abstract
Improved survival after acute graft-versus-host disease diagnosis in the modern era. View Abstract
Defibrotide for Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome: Interim Results from a Treatment IND Study. View Abstract
Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study. View Abstract
GvHD after umbilical cord blood transplantation for acute leukemia: an analysis of risk factors and effect on outcomes. View Abstract
Outcomes Following Bone Marrow Transplantation in Children With Accelerated Phase or Blast Crisis Chronic Myelogenous Leukemia in the Era of Tyrosine Kinase Inhibitors. View Abstract
Safety of peritoneal and pleural drain placement in pediatric stem cell transplant recipients with severe veno-occlusive disease. View Abstract
Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Risk Factors for Primary Infection and Cases of Recurrent and Late Infection at a Single Center. View Abstract
Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. View Abstract
Pursuing equity in cancer care: implementation, challenges and preliminary findings of a public cancer referral center in rural Rwanda. View Abstract
End-of-Life Care Patterns Associated with Pediatric Palliative Care among Children Who Underwent Hematopoietic Stem Cell Transplant. View Abstract
Treatment of Chronic Myeloid Leukemia in Rural Rwanda: Promising Early Outcomes. View Abstract
Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure. View Abstract
Treating Nephroblastoma in Rwanda: Using International Society of Pediatric Oncology Guidelines in a Novel Oncologic Care Model. View Abstract
Initiating Childhood Cancer Treatment in Rural Rwanda: A Partnership-Based Approach. View Abstract
Global Approach to Hematologic Malignancies. View Abstract
Comparison of toxicity following different conditioning regimens (busulfan/melphalan and carboplatin/etoposide/melphalan) for advanced stage neuroblastoma: Experience of two transplant centers. View Abstract
Use and Effectiveness of Gonadotropin-Releasing Hormone Agonists for Prophylactic Menstrual Suppression in Postmenarchal Women Who Undergo Hematopoietic Cell Transplantation. View Abstract
Capacity building for oncology programmes in sub-Saharan Africa: the Rwanda experience. View Abstract
Transplantation Outcomes for Children with Hypodiploid Acute Lymphoblastic Leukemia. View Abstract
Incidence and causes of hospital readmission in pediatric patients after hematopoietic cell transplantation. View Abstract
Prevalence and impact of financial hardship among New England pediatric stem cell transplantation families. View Abstract
A modified ?-retrovirus vector for X-linked severe combined immunodeficiency. View Abstract
Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children. View Abstract
Surgical consultation and intervention during pediatric hematopoietic stem cell transplantation. View Abstract
Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. View Abstract
Late effects in children treated with intensive multimodal therapy for high-risk neuroblastoma: high incidence of endocrine and growth problems. View Abstract
Transplantation for children with acute myeloid leukemia: a comparison of outcomes with reduced intensity and myeloablative regimens. View Abstract
Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome. View Abstract
Cyclophosphamide-associated cardiotoxicity in a child after stem cell transplantation for ß-thalassemia major: case report and review of the literature. View Abstract
Novel dominant ß-thalassemia: Hb Boston-Kuwait [codon 139/140(+T)]. View Abstract
Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. View Abstract
Outcome of transplantation for acute myelogenous leukemia in children with Down syndrome. View Abstract
Drug safety evaluation of defibrotide. View Abstract
The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy. View Abstract
Hematopoietic stem cell transplantation for thalassemia. View Abstract
How we treat oral chronic graft-versus-host disease. View Abstract
Defibrotide for the treatment of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. View Abstract
Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation? View Abstract
Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation. View Abstract
Safety and utility of liver biopsy after pediatric hematopoietic stem cell transplantation. View Abstract
Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. View Abstract
Hematopoietic cell transplantation comorbidity index predicts transplantation outcomes in pediatric patients. View Abstract
25-hydroxy vitamin D deficiency following pediatric hematopoietic stem cell transplant. View Abstract
Tolerability of pravastatin in pediatric hematopoietic stem cell transplant patients with bronchiolitis obliterans. View Abstract
End-of-life experience of children undergoing stem cell transplantation for malignancy: parent and provider perspectives and patterns of care. View Abstract
Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. View Abstract
Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study. View Abstract
Is blood thicker than water?: ethics of hematopoietic stem cell donation by biological siblings of adopted children. View Abstract
Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic graft-versus-host disease (cGVHD). View Abstract
Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic GVHD. View Abstract
Helicobacter pylori associated gastric Burkitt lymphoma. View Abstract
Bronchiolitis obliterans following pediatric allogeneic hematopoietic stem cell transplantation. View Abstract
Calcineurin inhibitor-associated oral inflammatory polyps after transplantation. View Abstract
A novel pattern of transaminase elevation associated with autologous transplant for neuroblastoma. View Abstract
Transverse myelitis after therapy for primitive neuroectodermal tumors. View Abstract
Estrogenic and clastogenic potential of the mycotoxin alternariol in cultured mammalian cells. View Abstract
Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. View Abstract
Influence of decreased intracellular glutathione level on the mutagenicity of patulin in cultured mouse lymphoma cells. View Abstract
Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. View Abstract
Favorable outcome of allogeneic hematopoietic stem cell transplantation for relapsed or refractory acute promyelocytic leukemia in childhood. View Abstract
Dyskeratosis congenita vs. chronic graft versus host disease: report of a case and a review of the literature. View Abstract
A multiagent strategy to decrease regimen-related toxicity in children undergoing allogeneic hematopoietic stem cell transplantation. View Abstract
Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein. View Abstract
Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. View Abstract
Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. View Abstract
Homozygous alpha-thalassemia treated with intrauterine transfusions and postnatal hematopoietic stem cell transplantation. View Abstract
Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantation. View Abstract
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-2003. A 15-year-old girl with pain in the left leg and back, pruritus, and thoracic lymphadenopathy. View Abstract
Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. View Abstract
A murine xenograft model for human CD30+ anaplastic large cell lymphoma. Successful growth inhibition with an anti-CD30 antibody (HeFi-1). View Abstract
Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma. View Abstract
Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia. View Abstract
Chromosome translocations in thyroid tissues from Belarussian children exposed to radioiodine from the Chernobyl accident, measured by FISH-painting. View Abstract
Relapsed acute lymphoblastic leukemia: similar outcomes for autologous and allogeneic marrow transplantation in selected children. View Abstract
[Patellar osteochondrosis dissecans--results of surgical therapy]. View Abstract
[Mesenteric plication by the Childs-Phillips method for the prevention and therapy of small intestine obstructions. Experiences in 148 cases]. View Abstract