Lise Nigrovic, MD, MPH

Senior Physician in Pediatrics, Division of Emergency Medicine

Professor of Pediatrics; Associate Professor of Emergency Medicine, Harvard Medical School

Phone 617-355-6624

Fax 617-730-0335

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NPI 1831156207

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Lise Nigrovic, MD, MPH

Senior Physician in Pediatrics, Division of Emergency Medicine

Professor of Pediatrics; Associate Professor of Emergency Medicine, Harvard Medical School

Medical Services

Languages

English

Education

Medical School

Harvard Medical School

1997

Boston

Residency

Boston Children's Hospital

2002

Boston

Fellowship

Boston Children's Hospital

2005

Boston

Graduate School

MPH

Harvard School of Public Health

2005

Boston

Certifications

American Board of Pediatrics (General)

American Board of Pediatrics (Emergency Medicine)

Publications

Urine Dipstick for the Diagnosis of Urinary Tract Infection in Febrile Infants Aged 2 to 6 Months. View Abstract

Utility of Cytokine Biomarkers for the Diagnosis of Pediatric Pyogenic Musculoskeletal Infections. View Abstract

Evaluation of Lyme serologic quantitative test indexes: High first-tier test index values predict positive second-tier result in standard and modified 2-tier Lyme testing algorithms. View Abstract

Comparative Evaluation of Commercial Test Kits Cleared for Use in Modified Two-Tiered Testing Algorithms for Serodiagnosis of Lyme Disease. View Abstract

Managing the Swollen Knee in a Child. View Abstract

Mapping the distribution of Lyme disease at a mid-Atlantic site in the United States using electronic health data. View Abstract

Increased usage of doxycycline for young children with Lyme disease. View Abstract

Utility of Synovial Fluid Biomarkers for Culture-Positive Septic Arthritis in a Lyme Disease-Endemic Region. View Abstract

Predictors of Invasive Bacterial Infection in Febrile Infants Aged 2 to 6 Months in the Emergency Department. View Abstract

Diagnostic Stewardship in the Evaluation of a Child With a Potential Central Nervous System Infection. View Abstract

Impact of COVID-19 and the cancellation of the 2020 PAS Meeting on abstract publications. View Abstract

Radiographic pneumonia in young febrile infants presenting to the emergency department: secondary analysis of a prospective cohort study. View Abstract

Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis. View Abstract

Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion. View Abstract

Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children. View Abstract

Biomarkers for Pediatric Bacterial Musculoskeletal Infections in Lyme Disease-Endemic Regions. View Abstract

Impact of the COVID-19 pandemic on pediatric faculty: a report from nine academic institutions. View Abstract

Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis. View Abstract

Racial Differences in the Diagnosis of Lyme Disease in Children. View Abstract

Multiplex High-Definition Polymerase Chain Reaction Assay for the Diagnosis of Tick-borne Infections in Children. View Abstract

Comparative effectiveness and complications of intravenous ceftriaxone compared with oral doxycycline in Lyme meningitis in children: a multicentre prospective cohort study. View Abstract

Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes. View Abstract

Relationships among biochemical measures in children with diabetic ketoacidosis. View Abstract

Trends in the Use of Procalcitonin at US Children's Hospital Emergency Departments. View Abstract

Serious Bacterial Infections in Young Febrile Infants With Positive Urinalysis Results. View Abstract

Pyuria in Children with Diabetic Ketoacidosis. View Abstract

Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis. View Abstract

Prevalence and Management of Invasive Bacterial Infections in Febrile Infants Ages 2 to 6 Months. View Abstract

Comprehensiveness of Testing Among Herpes Simplex Virus Infected Infants: A Multicenter Cohort Study. View Abstract

Empiric antibiotics for children with suspected Lyme disease. View Abstract

A Clinical Prediction Rule for Bacterial Musculoskeletal Infections in Children with Monoarthritis in Lyme Endemic Regions. View Abstract

Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area. View Abstract

Multisystem Inflammatory-like Syndrome in a Child Following COVID-19 mRNA Vaccination. View Abstract

Seasonality of Acute Lyme Disease in Children. View Abstract

Attending-Provider Handoffs and Pediatric Emergency Department Revisits. View Abstract

Two-Tier Lyme Disease Serology in Children with Previous Lyme Disease. View Abstract

The Pediatric Emergency Research Network: a decade old and growing. View Abstract

Changes in Antibiotic Treatment for Children With Lyme Meningitis 2015-2020. View Abstract

Predictors of Invasive Herpes Simplex Virus Infection in Young Infants. View Abstract

Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease. View Abstract

Serum Sodium Concentration and Mental Status in Children With Diabetic Ketoacidosis. View Abstract

Environmental Correlates of Lyme Disease Emergence in Southwest Virginia, 2005-2014. View Abstract

Electrocardiogram as a Lyme Disease Screening Test. View Abstract

The Pediatric Emergency Research Network (PERN): A decade of global research cooperation in paediatric emergency care. View Abstract

The Pediatric Emergency Research Network: A Decade of Global Research Cooperation in Pediatric Emergency Care. View Abstract

Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis. View Abstract

Managing Diabetic Ketoacidosis in Children. View Abstract

Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days. View Abstract

Validation of the Rule of 7's for Identifying Children at Low-risk for Lyme Meningitis. View Abstract

Research environment and resources to support pediatric emergency medicine fellow research. View Abstract

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. View Abstract

Characteristics of Afebrile Infants =60 Days of Age With Invasive Bacterial Infections. View Abstract

Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media. View Abstract

Febrile Infants =60 Days Old With Positive Urinalysis Results and Invasive Bacterial Infections. View Abstract

Pediatric Lyme Disease Biobank, United States, 2015-2020. View Abstract

Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes. View Abstract

Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. View Abstract

Kicking it through the uprights: getting it published after presenting at PAS. View Abstract

Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes. View Abstract

Time to Positive Blood and Cerebrospinal Fluid Cultures in Febrile Infants =60 Days of Age. View Abstract

The Infant Scalp Score: A Validated Tool to Stratify Risk of Traumatic Brain Injury in Infants With Isolated Scalp Hematoma. View Abstract

Use of Ondansetron for Vomiting After Head Trauma: Does It Mask Clinically Significant Traumatic Brain Injury? View Abstract

Marked Escalation in Journal Submissions During COVID-19 Pandemic. View Abstract

Hypertension during Diabetic Ketoacidosis in Children. View Abstract

Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. View Abstract

The Champagne Tap: Time to Pop the Cork? View Abstract

Performance of the Modified Boston and Philadelphia Criteria for Invasive Bacterial Infections. View Abstract

Development of a pediatric Lyme meningitis symptom measurement instrument using a Delphi technique. View Abstract

Research Interest in Pediatric Emergency Medicine Fellows. View Abstract

Application of the Bacterial Meningitis Score for Infants Aged 0 to 60 Days. View Abstract

Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. View Abstract

The Lyme Disease Polymerase Chain Reaction Test Has Low Sensitivity. View Abstract

A Bayesian Spatiotemporal Analysis of Pediatric Group A Streptococcal Infections. View Abstract

Children With Minor Blunt Head Trauma Presenting to the Emergency Department. View Abstract

What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. View Abstract

Provider-Level and Hospital-Level Factors and Process Measures of Quality Care Delivered in Pediatric Emergency Departments. View Abstract

Cerebrospinal Fluid Profiles of Infants =60 Days of Age With Bacterial Meningitis. View Abstract

Evaluation of the Modified Two-Tiered Testing Method for Diagnosis of Lyme Disease in Children. View Abstract

Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections. View Abstract

State of the Journal: Women First Authors, Peer Reviewers, and Editorial Board Members at Annals of Emergency Medicine. View Abstract

A Prediction Model to Identify Febrile Infants =60 Days at Low Risk of Invasive Bacterial Infection. View Abstract

Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants =60 Days of Age Undergoing Evaluation for Meningitis. View Abstract

Positive 2-Tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the United States. View Abstract

Systematic review and meta-analysis found significant risk of brain injury and neurosurgery in alert children after a post-traumatic seizure. View Abstract

A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections. View Abstract

A minority of children diagnosed with Lyme disease recall a preceding tick bite. View Abstract

Impact of a Resident Research Grant on Scholarly Output During Pediatric Residency. View Abstract

Application of the Rochester Criteria to Identify Febrile Infants With Bacteremia and Meningitis. View Abstract

Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. View Abstract

Pediatric Emergency Care Research Networks: A Research Agenda. View Abstract

Oral Ondansetron to Reduce Intravenous Fluid Rehydration: Context Matters. View Abstract

Risk Stratification of Febrile Infants =60 Days Old Without Routine Lumbar Puncture. View Abstract

C-reactive protein or erythrocyte sedimentation rate results reliably exclude invasive bacterial infections. View Abstract

Validating a Clinical Prediction Rule for Ventricular Shunt Malfunction. View Abstract

Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma: A Cluster Randomized Trial. View Abstract

A Brush with Danger. View Abstract

Time to Pathogen Detection for Non-ill Versus Ill-Appearing Infants =60 Days Old With Bacteremia and Meningitis. View Abstract

A method to identify pediatric high-risk diagnoses missed in the emergency department. View Abstract

Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. View Abstract

Accuracy of Herpes Simplex Virus Polymerase Chain Reaction Testing of the Blood for Central Nervous System Herpes Simplex Virus Infections in Infants. View Abstract

Epidemiology and Etiology of Invasive Bacterial Infection in Infants =60 Days Old Treated in Emergency Departments. View Abstract

Would Parents Consent to a Comparative Effectiveness Trial of Oral Doxycycline Versus Intravenous Ceftriaxone for the Treatment of Children with Lyme Meningitis? View Abstract

Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area. View Abstract

Teaching Incision and Drainage: Perceived Educational Value of Abscess Models. View Abstract

Evaluation of a sequential enzyme immunoassay testing algorithm for Lyme disease demonstrates lack of test independence but high diagnostic specificity. View Abstract

Cerebrospinal Fluid Reference Values for Young Infants Undergoing Lumbar Puncture. View Abstract

Herpes Simplex Virus Infection in Infants Undergoing Meningitis Evaluation. View Abstract

Patient-level Factors and the Quality of Care Delivered in Pediatric Emergency Departments. View Abstract

Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department. View Abstract

A Systematic Review and Meta-Analysis of the Management and Outcomes of Isolated Skull Fractures in Children. View Abstract

Implicit Review Instrument to Evaluate Quality of Care Delivered by Physicians to Children in Emergency Departments. View Abstract

Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections. View Abstract

Managing Peripheral Facial Palsy. View Abstract

Educational Initiative to Standardize Concussion Management in Pediatric Primary Care. View Abstract

X Marks the Spot (or Does It?): Ultrasonography-Assisted Site Marking for Lumbar Puncture in Children: Answers to the May 2017 Journal Club Questions. View Abstract

Correction of Cerebrospinal Fluid Protein in Infants With Traumatic Lumbar Punctures. View Abstract

Concomitant Bacterial Meningitis in Infants With Urinary Tract Infection. View Abstract

Utility of Lumbar Puncture in Children Presenting With Status Epilepticus. View Abstract

Empiric Antibiotic Use and Susceptibility in Infants With Bacterial Infections: A Multicenter Retrospective Cohort Study. View Abstract

Impact of Enteroviral Polymerase Chain Reaction Testing on Length of Stay for Infants 60 Days Old or Younger. View Abstract

The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants. View Abstract

Diagnostic Lumbar Puncture Among Children With Facial Palsy in a Lyme Disease Endemic Area. View Abstract

X Marks the Spot (or Does It?): Ultrasonography-Assisted Site Marking for Lumbar Puncture in Children: May 2017 Annals of Emergency Medicine Journal Club. View Abstract

Research priorities for a multi-center child abuse network: Lessons learned from pediatric emergency medicine networks. View Abstract

Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. View Abstract

Complexity and Severity of Pediatric Patients Treated at United States Emergency Departments. View Abstract

Geographic Expansion of Lyme Disease in Michigan, 2000-2014. View Abstract

Interpretation of Cerebrospinal Fluid White Blood Cell Counts in Young Infants With a Traumatic Lumbar Puncture. View Abstract

Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. View Abstract

Evaluation of the C6 Lyme Enzyme Immunoassay for the Diagnosis of Lyme Disease in Children and Adolescents. View Abstract

Diagnosis of Lyme disease in the pediatric acute care setting. View Abstract

A QI Initiative to Reduce Hospitalization for Children With Isolated Skull Fractures. View Abstract

False Positive Lyme Disease IgM Immunoblots in Children. View Abstract

Efficacy of an Interinstitutional Mentoring Program Within Pediatric Rheumatology. View Abstract

Validation of the bacterial meningitis score in adults presenting to the ED with meningitis. View Abstract

Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus. View Abstract

The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children. View Abstract

Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice. View Abstract

Geographic Expansion of Lyme Disease in the Southeastern United States, 2000-2014. View Abstract

Accuracy of diagnosis codes to identify febrile young infants using administrative data. View Abstract

Motor Vehicle Crash Fatalities in States With Primary Versus Secondary Seat Belt Laws: A Time-Series Analysis. View Abstract

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence. View Abstract

Quality Improvement Effort to Reduce Cranial CTs for Children With Minor Blunt Head Trauma. View Abstract

Trends in Ambulatory Care for Children with Concussion and Minor Head Injury from Eastern Massachusetts between 2007 and 2013. View Abstract

Radiographic evaluation of pediatric cerebrospinal fluid shunt malfunction in the emergency setting. View Abstract

Association of clinical practice guidelines with emergency department management of febrile infants =56 days of age. View Abstract

The effect of traumatic lumbar puncture on hospitalization rate for febrile infants 28 to 60 days of age. View Abstract

The Yield of Neuroimaging in Children Presenting to the Emergency Department With Acute Ataxia in the Post-Varicella Vaccine Era. View Abstract

Sick kids look sick. View Abstract

Variation in care of the febrile young infant <90 days in US pediatric emergency departments. View Abstract

Comparison of rapid cranial MRI to CT for ventricular shunt malfunction. View Abstract

Incorrect classification in articles about traumatic brain injuries in children with minor blunt head trauma. View Abstract

Pediatric status epilepticus: how common is cerebrospinal fluid pleocytosis in the absence of infection? View Abstract

Cerebrospinal fluid lactate level as a diagnostic biomarker for bacterial meningitis in children. View Abstract

Pediatric Emergency Care Applied Research Network head injury clinical prediction rules are reliable in practice. View Abstract

Synovial fluid findings in children with knee monoarthritis in lyme disease endemic areas. View Abstract

Spinal cord injury without radiologic abnormality in children imaged with magnetic resonance imaging. View Abstract

Characteristics of the pediatric patients treated by the Pediatric Emergency Care Applied Research Network's affiliated EMS agencies. View Abstract

Validation of anaphylaxis in the Food and Drug Administration's Mini-Sentinel. View Abstract

The bacterial meningitis score to distinguish bacterial from aseptic meningitis in children from Sao Paulo, Brazil. View Abstract

Nurse and physician agreement in the assessment of minor blunt head trauma. View Abstract

Effect of the duration of emergency department observation on computed tomography use in children with minor blunt head trauma. View Abstract

Informing the design of clinical decision support services for evaluation of children with minor blunt head trauma in the emergency department: a sociotechnical analysis. View Abstract

The effect of recommending cognitive rest on recovery from sport-related concussion. View Abstract

Isolated skull fractures: trends in management in US pediatric emergency departments. View Abstract

Enteroviral testing and length of hospital stay for children evaluated for lyme meningitis. View Abstract

Trends in the management of viral meningitis at United States children's hospitals. View Abstract

Distinguishing Lyme from septic knee monoarthritis in Lyme disease-endemic areas. View Abstract

Aseptic meningitis. View Abstract

Booster seat laws and fatalities in children 4 to 7 years of age. View Abstract

The prevalence of traumatic brain injuries after minor blunt head trauma in children with ventricular shunts. View Abstract

Treatment complications in children with lyme meningitis. View Abstract

Pediatric traumatic brain injury and radiation risks: a clinical decision analysis. View Abstract

Electrocardiograph Abnormalities in Children With Lyme Meningitis. View Abstract

Meta-analysis of bacterial meningitis score validation studies. View Abstract

Impact of in-hospital enteroviral polymerase chain reaction testing on the clinical management of children with meningitis. View Abstract

Predictors of ventricular shunt infection among children presenting to a pediatric emergency department. View Abstract

Utility of plain radiographs in detecting traumatic injuries of the cervical spine in children. View Abstract

Factors influencing neurological outcome of children with bacterial meningitis at the emergency department. View Abstract

Rapid sequence intubation for pediatric emergency patients: higher frequency of failed attempts and adverse effects found by video review. View Abstract

Adjustment of cerebrospinal fluid protein for red blood cells in neonates and young infants. View Abstract

Relationship between cerebrospinal fluid glucose and serum glucose. View Abstract

Validation of a clinical prediction rule to distinguish Lyme meningitis from aseptic meningitis. View Abstract

Prevalence of clinically important traumatic brain injuries in children with minor blunt head trauma and isolated severe injury mechanisms. View Abstract

Factors associated with the use of cervical spine computed tomography imaging in pediatric trauma patients. View Abstract

The effect of observation on cranial computed tomography utilization for children after blunt head trauma. View Abstract

Correction of cerebrospinal fluid protein for the presence of red blood cells in children with a traumatic lumbar puncture. View Abstract

Integrating spatial epidemiology into a decision model for evaluation of facial palsy in children. View Abstract

Low risk of bacterial meningitis in children with a positive enteroviral polymerase chain reaction test result. View Abstract

Factors associated with cervical spine injury in children after blunt trauma. View Abstract

Use of population health data to refine diagnostic decision-making for pertussis. View Abstract

Diagnostic value of immature neutrophils (bands) in the cerebrospinal fluid of children with cerebrospinal fluid pleocytosis. View Abstract

Cerebrospinal fluid pleocytosis in children in the era of bacterial conjugate vaccines: distinguishing the child with bacterial and aseptic meningitis. View Abstract

Clinical predictors of Lyme disease among children with a peripheral facial palsy at an emergency department in a Lyme disease-endemic area. View Abstract

Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. View Abstract

Tularemia. View Abstract

Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. View Abstract

Cerebrospinal fluid xanthochromia in newborns is related to maternal labor before delivery. View Abstract

Lumbar puncture success rate is not influenced by family-member presence. View Abstract

Letter in response. Clinical decision rule to identify patients at very low risk of bacterial meningitis View Abstract

Risk factors for traumatic or unsuccessful lumbar punctures in children. View Abstract

Linking surveillance to action: incorporation of real-time regional data into a medical decision rule. View Abstract

Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. View Abstract

Patients with juvenile psoriatic arthritis comprise two distinct populations. View Abstract

The Lyme vaccine: a cautionary tale. View Abstract

Extreme thrombocytosis predicts Kawasaki disease in infants. View Abstract

Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. View Abstract

Evaluation of the febrile child 3 to 36 months old in the era of the pneumococcal conjugate vaccine: focus on occult bacteremia View Abstract

Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. View Abstract

Rotavirus cerebellitis? View Abstract

Introduction. View Abstract

What's new with enteroviral infections? View Abstract

Oral and airway sequelae after hair relaxer ingestion. View Abstract

Cost analysis of enteroviral polymerase chain reaction in infants with fever and cerebrospinal fluid pleocytosis. View Abstract

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