Marian H. Harris, MD, PhD
Director, Laboratory for Molecular Pediatric Pathology (LaMPP); Hematopathology; Molecular Pathology, Department of Pathology
Assistant Professor of Pathology, Harvard Medical School
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Marian H. Harris, MD, PhD
Director, Laboratory for Molecular Pediatric Pathology (LaMPP); Hematopathology; Molecular Pathology, Department of Pathology
Assistant Professor of Pathology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Yale University
1993
New Haven
CT
Medical School
University of Pennsylvania
2003
Philadelphia
PA
Graduate School
PhD
University of Pennsylvania
2004
Philadelphia
PA
Residency
Anatomic Pathology
Brigham and Women's Hospital
2006
Boston
MA
Fellowship
Hematopathology
Brigham and Women's Hospital
2008
Boston
MA
Fellowship
Molecular Genetic Pathology
Harvard Medical School
2010
Boston
MA
Certifications
American Board of Pathology (Hematopathology)
American Board of Pathology (Anatomic Molecular Genetics)
Publications
Lymphoid malignancies in patients with Shwachman-Diamond syndrome. View Abstract
Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy. View Abstract
Genome-wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia. View Abstract
Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers. View Abstract
Acute Promyelocytic Leukemia With Torque Teno Mini Virus::RARA Fusion: An Approach to Screening and Diagnosis. View Abstract
Response to "Comment on 'State-of-the-Science Data and Methods Need to Guide Place-Based Efforts to Reduce Air Pollution Inequity'". View Abstract
IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia. View Abstract
State-of-the-Science Data and Methods Need to Guide Place-Based Efforts to Reduce Air Pollution Inequity. View Abstract
ETV6 fusions from insertions of exons 3-5 in pediatric hematologic malignancies. View Abstract
Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. View Abstract
Ethnoracial Disparities in Nitrogen Dioxide Pollution in the United States: Comparing Data Sets from Satellites, Models, and Monitors. View Abstract
Outlier Expression of Isoforms by Targeted or Total RNA Sequencing Identifies Clinically Significant Genomic Variants in Hematolymphoid Tumors. View Abstract
Plasma concentrations of per- and polyfluoroalkyl substances in pregnancy and breastfeeding duration in Project Viva. View Abstract
National and Intraurban Air Pollution Exposure Disparity Estimates in the United States: Impact of Data-Aggregation Spatial Scale. View Abstract
Allelic complexity of KMT2A partial tandem duplications in acute myeloid leukemia and myelodysplastic syndromes. View Abstract
Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer. View Abstract
Insights from Application of a Hierarchical Spatio-Temporal Model to an Intensive Urban Black Carbon Monitoring Dataset. View Abstract
Predictors of thrombosis in children receiving therapy for acute lymphoblastic leukemia: Results from Dana-Farber Cancer Institute ALL Consortium trial 05-001. View Abstract
Gene Rearrangement Detection in Pediatric Leukemia. View Abstract
Assessment of BCOR Internal Tandem Duplications in Pediatric Cancers by Targeted RNA Sequencing. View Abstract
Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) and child executive function and behavioral problems. View Abstract
Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001. View Abstract
Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository. View Abstract
Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL. View Abstract
Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. View Abstract
Genetic ancestry and skeletal toxicities among childhood acute lymphoblastic leukemia patients in the DFCI 05-001 cohort. View Abstract
Corrigendum. View Abstract
Identification of prognostic factors in childhood T-cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocols 05-001 and 11-001. View Abstract
Making the most of small samples: Optimization of tissue allocation of pediatric solid tumors for clinical and research use. View Abstract
Recurrent RET gene fusions in paediatric spindle mesenchymal neoplasms. View Abstract
Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma. View Abstract
Recurrent and novel USP6 fusions in cranial fasciitis identified by targeted RNA sequencing. View Abstract
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. View Abstract
A Distinctive Genomic and Immunohistochemical Profile for NOTCH3 and PDGFRB in Myofibroma With Diagnostic and Therapeutic Implications. View Abstract
Genetic Testing in the Diagnosis and Biology of Acute Leukemia. View Abstract
High NPM1 mutant allele burden at diagnosis correlates with minimal residual disease at first remission in de novo acute myeloid leukemia. View Abstract
Erratum: Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA). View Abstract
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations. View Abstract
Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). View Abstract
Erratum: "Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture". View Abstract
Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001. View Abstract
Outcome of children and adolescents with Down syndrome treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium protocols 00-001 and 05-001. View Abstract
Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition. View Abstract
Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture. View Abstract
Phase I trial of the mTOR inhibitor everolimus in combination with multi-agent chemotherapy in relapsed childhood acute lymphoblastic leukemia. View Abstract
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. View Abstract
Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. View Abstract
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. View Abstract
Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. View Abstract
Predictors of Per- and Polyfluoroalkyl Substance (PFAS) Plasma Concentrations in 6-10 Year Old American Children. View Abstract
Clinical, Pathologic, and Genetic Features of Wilms Tumors With WTX Gene Mutation. View Abstract
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. View Abstract
Prenatal and childhood traffic-related air pollution exposure and childhood executive function and behavior. View Abstract
Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations. View Abstract
Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study. View Abstract
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. View Abstract
Clinical, pathologic, and genetic features of Wilms tumors with WTX gene mutation. View Abstract
Infant Breastfeeding Duration and Mid-Childhood Executive Function, Behavior, and Social-Emotional Development. View Abstract
Intravenous pegylated asparaginase versus intramuscular native Escherichia coli L-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial. View Abstract
Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma. View Abstract
Sociodemographic and Perinatal Predictors of Early Pregnancy Per- and Polyfluoroalkyl Substance (PFAS) Concentrations. View Abstract
Prenatal and Childhood Traffic-Related Pollution Exposure and Childhood Cognition in the Project Viva Cohort (Massachusetts, USA). View Abstract
Imaging findings in children with proliferative disorders following multivisceral transplantation. View Abstract
Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. View Abstract
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. View Abstract
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia. View Abstract
c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. View Abstract
The MLL recombinome of acute leukemias in 2013. View Abstract
Future of clinical genomics in pediatric oncology. View Abstract
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. View Abstract
Anaplastic large cell lymphoma of the esophagus in a pediatric patient. View Abstract
MicroRNA miR-125b causes leukemia. View Abstract
SBDS protein expression patterns in the bone marrow. View Abstract
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. View Abstract
Extranodal natural killer cell/t-cell lymphoma, nasal type, presenting as cutaneous nodules and a small-bowel perforation. View Abstract
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. View Abstract
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. View Abstract
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. View Abstract
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. View Abstract
Akt stimulates aerobic glycolysis in cancer cells. View Abstract
The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. View Abstract
Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. View Abstract
Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. View Abstract
The CD28 signaling pathway regulates glucose metabolism. View Abstract
Growth factors can influence cell growth and survival through effects on glucose metabolism. View Abstract
The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. View Abstract
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. View Abstract
Role of oxidative phosphorylation in Bax toxicity. View Abstract
The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). View Abstract
What keeps a resting T cell alive? View Abstract
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