Nilesh Mehta, MD
Chief of Critical Care Medicine; Chair, Critical Care Nutrition & Metabolism, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia (Critical Care), Harvard Medical School
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617-730-0453
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1932317906
Nilesh Mehta, MD
Chief of Critical Care Medicine; Chair, Critical Care Nutrition & Metabolism, Department of Anesthesiology, Critical Care and Pain Medicine
Professor of Anaesthesia (Critical Care), Harvard Medical School
Medical Services
Languages
English
Education
Medical School
T. N. Medical College
Bombay
India
Internship
King Edward VII Memorial Hospital
Bombay
India
Residency
Pediatric Medicine
North Thames Deanery
London
England
Residency
Pediatrics
Boston Combined Residency Program (BCRP)
Boston
MA
Fellowship
Critical Care Medicine
Boston Children's Hospital
Boston
MA
Fellowship
Pediatric Critical Care
St. Mary's Hospital
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Critical Care Medicine)
Professional History
Dr. Nilesh Mehta is the Chief of Critical Care Medicine Division. He is the Anesthesia Chair for Critical Care Nutrition and Metabolism. He is Professor of Anesthesia (Critical Care) at Harvard Medical School. He has a long track record of mentorship, funded research (clinical and translational studies and trials) in the field of critical care nutrition and metabolism. He is the founder and Director (2010 - 2020) of the multidisciplinary institutional Pediatric Critical Care Nutrition program. Dr. Mehta served as the 42nd President, and Chair of the Corporate Scientific Advisory Council (CSAC), and he is currently on the Board of Advisors of the American Society of Parenteral and Enteral Nutrition (ASPEN). He is the recipient of the Stanley Dudrick Research Scholar Award (He is the founder and Director (2010 - 2020) of the multidisciplinary institutional Pediatric Critical Care Nutrition program.
He is the Executive Director of PICU CLOUD (Collaborative Learning through Outcomes Data sharing) – a consortium of 24 PICUs at leading academic centers in 12 countries. He is the founder and Executive Director of the the Perioperative and Critical Care – Center for Outcomes Research and Evaluation (PC-CORE), novel interdisciplinary platform to harness emerging technology to create clinical decision making tools, guide the Departmental data strategy, and evaluate effectiveness of care.
Publications
Bowel regimen medication use and its effect on bowel movements in a pediatric intensive care unit: A retrospective study. View Abstract
Using Implementation Science to Assess Barriers to Agreement on Sedation Goal Setting and Assessment. View Abstract
Nutrition support in children with medical complexity and chronic critical illness: A narrative review. View Abstract
Epidemiology and Regional Variation in Additional Surgical Interventions for Children with Congenital Diaphragmatic Hernia: A Multi-institutional Analysis. View Abstract
Nutrition Provision in Children with Heart Disease on Extracorporeal Membrane Oxygenation (ECMO). View Abstract
The enteroendocrine axis and its effect on gastrointestinal function, nutrition, and inflammation. View Abstract
Changes in Global Nutrition Practices in Critically Ill Children and the Influence of Emerging Evidence: A Secondary Analysis of the Pediatric International Nutrition Studies, 2009-2018. View Abstract
Comparing the Quality of Domain-Specific Versus General Language Models for Artificial Intelligence-Generated Differential Diagnoses in PICU Patients. View Abstract
Automated Calculator for the Pediatric Sequential Organ Failure Assessment Score: Development and External Validation in a Single-Center 7-Year Cohort, 2015-2021. View Abstract
Dynamic Prediction of Mortality Using Longitudinally Measured Pediatric Sequential Organ Failure Assessment Scores: A Joint Modeling Approach. View Abstract
Stress Ulcer Prophylaxis Versus Placebo-A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease. View Abstract
Medication Errors: Detection Methodology Matters. View Abstract
Improving anthropometric measurements in hospitalized children: A quality-improvement project. View Abstract
Determining energy and protein needs in critically ill pediatric patients: A scoping review. View Abstract
Heart Rate Change as a Potential Digital Biomarker of Brain Death in Critically Ill Children With Acute Catastrophic Brain Injury. View Abstract
Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia. View Abstract
Validation and Extension of the Association Between Potentially Excess Oxygen Exposure and Death in Mechanically Ventilated Children. View Abstract
Postpyloric vs gastric enteral nutrition in critically ill children: A single-center retrospective cohort study. View Abstract
Impact of implementing an evidence-based definition of enteral nutrition intolerance on nutrition delivery: A prospective, cross-sectional cohort study. View Abstract
Intermittent versus continuous enteral nutrition in critically ill children: A pre-planned secondary analysis of an international prospective cohort study. View Abstract
Quality measurement and surveillance platforms in critically ill children: A scoping review. View Abstract
Bio-impedance spectroscopy for total body water assessment in pediatric surgical patients: A single center pilot cohort study. View Abstract
Implementation Science in Pediatric Critical Care - Sedation and Analgesia Practices as a Case Study. View Abstract
The Zonulin Pathway as a Potential Mediator of Gastrointestinal Dysfunction in Critical Illness. View Abstract
Nutritional screening tool for critically ill children: a systematic review. View Abstract
Resuscitation With Vitamins C and B1 in Pediatric Sepsis-Hold on to Your "HAT". View Abstract
Supraventricular Tachycardia in Infants With Congenital Diaphragmatic Hernia: Prevalence, Associations, and Outcomes. View Abstract
Feasibility of bioimpedance spectroscopy and long-term functional assessment in critically ill children. View Abstract
Association Between Anticholinergic Drug Burden and Adequacy of Enteral Nutrition in Critically Ill, Mechanically Ventilated Pediatric Patients. View Abstract
Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study. View Abstract
Time to achieve delivery of nutrition targets is associated with clinical outcomes in critically ill children. View Abstract
Artificial Neural Network Algorithms to Predict Resting Energy Expenditure in Critically Ill Children. View Abstract
Fluid Restriction Contributes to Poor Nutritional Adequacy in Patients With Congenital Heart Disease Receiving Renal Replacement Therapy. View Abstract
Ultrasound Assessment of Quadriceps Femoris Muscle Thickness in Critically Ill Children. View Abstract
Implementation of an Analgesia-Sedation Protocol Is Associated With Reduction in Midazolam Usage in the PICU. View Abstract
eSIMPLER: A Dynamic, Electronic Health Record-Integrated Checklist for Clinical Decision Support During PICU Daily Rounds. View Abstract
"Closing the chasm" - guidelines bridge the gap from evidence to implementation. View Abstract
Nutrition therapy and outcomes in hospitalized children. View Abstract
Nutrition delivery and growth outcomes in infants with long-gap esophageal atresia who undergo the Foker process. View Abstract
A Machine Learning Classifier Improves Mortality Prediction Compared With Pediatric Logistic Organ Dysfunction-2 Score: Model Development and Validation. View Abstract
Admission factors associated with nutritional status deterioration and prolonged pediatric intensive care unit stay in critically ill children: PICU-ScREEN multicenter study. View Abstract
Metabolism and energy prescription in critically ill children. View Abstract
Timing of parenteral nutrition is associated with adequacy of nutrient delivery and anthropometry in critically ill children: A single-center study. View Abstract
Stewardship Intervention to Optimize Central Venous Catheter Utilization in Critically Ill Children. View Abstract
Pediatric Sarcopenia: Hidden in Plain Sight? View Abstract
Sample Preparation for High-Throughput Urine Proteomics Using 96-Well Polyvinylidene Fluoride (PVDF) Membranes. View Abstract
Current State of Nutrition Education in Pediatric Critical Care Medicine Fellowship Programs in the United States and Canada. View Abstract
Biomarkers in critical care nutrition. View Abstract
Estimating Energy Expenditure and Metabolism at the Bedside-Still Shooting in the Dark? View Abstract
Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). View Abstract
Interleukin-10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study. View Abstract
Forty-Third ASPEN Presidential Address: "Our Time Is Now-Challenges and Strategies for the Field of Nutrition". View Abstract
Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial. View Abstract
Long-term outcomes related to timing of parenteral nutrition in critically ill children. View Abstract
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. View Abstract
Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. View Abstract
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. View Abstract
Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. View Abstract
Bedside Postpyloric Tube Placement and Enteral Nutrition Delivery in the Pediatric Intensive Care Unit. View Abstract
Multidisciplinary Quality Improvement Intervention to Achieve Sustained Improvement in Hand Hygiene Reliability in a Pediatric Intensive Care Unit. View Abstract
Undernutrition at PICU Admission Is Predictor of 60-Day Mortality and PICU Length of Stay in Critically Ill Children. View Abstract
ICU Management & Practice. Ed. J.L.Vincent View Abstract
From body habitus to body composition-Predicting outcomes in the PICU. View Abstract
Gastrointestinal Hormone Profiles Associated With Enteral Nutrition Tolerance and Gastric Emptying in Pediatric Critical Illness: A Pilot Study. View Abstract
ICU Management & Practice, Ed. J.L. Vincent View Abstract
Incorporating the latest pediatric nutrition support guidelines into clinical practice. View Abstract
Priorities for Nutrition Research in Pediatric Critical Care. View Abstract
Nutritional Status and Outcomes in Pediatric Severe Sepsis-Size Matters. View Abstract
Nutrition Support During Pediatric Extracorporeal Membrane Oxygenation. View Abstract
Micronutrients in Critical Illness: Essential and Enigmatic. View Abstract
Research Agenda 2018: The American Society for Parenteral and Enteral Nutrition. View Abstract
Enteral Protein Supplementation in Critically Ill Children: A Randomized Controlled Pilot and Feasibility Study. View Abstract
Nutrition for term neonates in the paediatric intensive care unit. View Abstract
Nutrition Delivery During Pediatric Extracorporeal Membrane Oxygenation Therapy. View Abstract
Comprehensive nutritional and metabolic assessment in patients with spinal muscular atrophy: Opportunity for an individualized approach. View Abstract
Unexplained iron deficiency anemia: does Helicobacter pylori have a role to play? View Abstract
Feeding the Critically Ill Child View Abstract
Nutrition Delivery and Growth Outcomes in Infants With Gastroschisis. View Abstract
Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single-Dose 15 N Glycine Stable Isotope Protocol With End-Product Enrichment. View Abstract
Feasibility of Enteral Protein Supplementation in Critically Ill Children. View Abstract
The Quest to Preserve Muscle Mass-Lessons From Pediatric Burn Injury. View Abstract
Response to "Pediatric Intensive Care Nutrition Guidelines 2017: Key Questions Remain Unanswered". View Abstract
Body Composition in Children with Chronic Illness: Accuracy of Bedside Assessment Techniques. View Abstract
Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice. View Abstract
Ultrasound Measurement of Muscle Thickness: A Novel Biomarker for the PICU? View Abstract
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. View Abstract
Risk Factors for Fractures in Children Hospitalized in Intensive and Intermediate Care Units. View Abstract
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. View Abstract
Impact of the structure and dose of protein intake on clinical and metabolic outcomes in critically ill children: A systematic review. View Abstract
Timing of the initiation of parenteral nutrition in critically ill children. View Abstract
Nutritional Assessment Must be Prioritized for Critically Ill Children in the PICU. View Abstract
Estimating Energy Expenditure in Critically Ill Children: Still Shooting in the Dark? View Abstract
Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. View Abstract
Gastric Emptying in Critically Ill Children. View Abstract
Optimal nutrition therapy in paediatric critical care in the Asia-Pacific and Middle East: a consensus. View Abstract
450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. View Abstract
451: INACCURACY OF EXISTING FAT-FREE MASS EQUATIONS IN PEDIATRICS-AND A NEW MACHINE LEARNING METHOD. View Abstract
462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. View Abstract
478: PROTEIN DELIVERY DURING THE FIRST WEEK OF PEDIATRIC ECMO: IMPACT ON OUTCOMES. View Abstract
1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. View Abstract
Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single-Dose 15N Glycine Stable Isotope Protocol With End-Product Enrichment. View Abstract
Nutrient delivery in mechanically ventilated surgical patients in the pediatric critical care unit. View Abstract
Nutritional status, metabolic state and nutrient intake in children with bronchiolitis. View Abstract
Energy and Protein Delivery in Overweight and Obese Children in the Pediatric Intensive Care Unit. View Abstract
Enteral Nutrition and Acid-Suppressive Therapy in the PICU: Impact on the Risk of Ventilator-Associated Pneumonia. View Abstract
The authors reply. View Abstract
Benefits of late parenteral nutrition in critically ill children. View Abstract
The science and art of pediatric critical care nutrition. View Abstract
Nutritional Status Based on Body Mass Index Is Associated With Morbidity and Mortality in Mechanically Ventilated Critically Ill Children in the PICU. View Abstract
Nutritional status as a predictor of duration of mechanical ventilation in critically ill children. View Abstract
Diagnosing Malnutrition: Where Are We and Where Do We Need to Go? View Abstract
Problems With Optimal Energy and Protein Delivery in the Pediatric Intensive Care Unit. View Abstract
International Pediatric Otolaryngology Group (IPOG) consensus recommendations: Routine peri-operative pediatric tracheotomy care. View Abstract
Parenteral Nutrition in Critically Ill Children. View Abstract
Worldwide Survey of Nutritional Practices in PICUs. View Abstract
Survey of contemporary feeding practices in critically ill children in the Asia-Pacific and the Middle East. View Abstract
A Comparison of Carbon Dioxide Elimination Measurements Between a Portable Indirect Calorimeter and Volumetric Capnography Monitor: An In Vitro Simulation. View Abstract
Nutritional Status and Nutrient Intake Challenges in Children With Spinal Muscular Atrophy. View Abstract
Gastric Dysmotility in Critically Ill Children: Pathophysiology, Diagnosis, and Management. View Abstract
Early Enteral Nutrition in the PICU: Should We Trust Our Gut? View Abstract
Unplanned extubation: securing the tool of our trade. View Abstract
Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study. View Abstract
Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study. View Abstract
Validation of the V(max) metabolic cart in a simulated pediatric model. View Abstract
Bringing back the (weighing) balance in the PICU--for good measure. View Abstract
Challenges to nutrition therapy in the pediatric critically ill obese patient. View Abstract
Carbon dioxide elimination and oxygen consumption in mechanically ventilated children. View Abstract
Energy expenditure: how much does it matter in infant and pediatric chronic disorders? View Abstract
Metabolic assessment and individualized nutrition in children dependent on mechanical ventilation at home. View Abstract
Nutritional outcomes in survivors of congenital diaphragmatic hernia (CDH)-factors associated with growth at one year. View Abstract
A stepwise enteral nutrition algorithm for critically ill children helps achieve nutrient delivery goals*. View Abstract
Comparison of body composition assessment methods in pediatric intestinal failure. View Abstract
Variability of resting energy expenditure in infants and young children with intestinal failure-associated liver disease. View Abstract
Nutrition algorithms and bedside nutrient delivery practices in pediatric intensive care units: an international multicenter cohort study. View Abstract
Current applications of metabolic monitoring in the pediatric intensive care unit. View Abstract
Accuracy of a simplified equation for energy expenditure based on bedside volumetric carbon dioxide elimination measurement--a two-center study. View Abstract
Feeding the gut during critical illness--it is about time. View Abstract
Effective Nutritional Therapy. 8/2013. Online Video View Abstract
Influence of obesity on clinical outcomes in hospitalized children: a systematic review. View Abstract
The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). View Abstract
Accuracy of gas exchange monitoring during noninvasive ventilation: an in vitro metabolic simulation. View Abstract
Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions. View Abstract
Gas exchange measurement during pediatric mechanical ventilation--agreement between gas sampling at the airway and the ventilator exhaust. View Abstract
The Goldilocks conundrum for optimal macronutrient delivery in the PICU--too much, too little, or just right? View Abstract
Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study*. View Abstract
Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects. View Abstract
Accuracy of abbreviated indirect calorimetry protocols for energy expenditure measurement in critically ill children. View Abstract
Nutrition therapy in the critically ill child. View Abstract
Systematic review of the influence of energy and protein intake on protein balance in critically ill children. View Abstract
Attenuation of resting energy expenditure following hematopoietic SCT in children. View Abstract
Energy imbalance and the risk of overfeeding in critically ill children. View Abstract
An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer. View Abstract
Factors associated with survival in pediatric extracorporeal membrane oxygenation--a single-center experience. View Abstract
Challenges to optimal enteral nutrition in a multidisciplinary pediatric intensive care unit. View Abstract
Nutritional deficiencies during critical illness. View Abstract
Approach to enteral feeding in the PICU. View Abstract
A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. View Abstract
Cumulative energy imbalance in the pediatric intensive care unit: role of targeted indirect calorimetry. View Abstract
Severe weight loss and hypermetabolic paroxysmal dysautonomia following hypoxic ischemic brain injury: the role of indirect calorimetry in the intensive care unit. View Abstract
Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. View Abstract
Genetic polymorphisms in acute respiratory distress syndrome: new approach to an old problem. View Abstract
Mechanical ventilation in children with acute respiratory failure. View Abstract
Cases of congenital rubella may be the tip of the iceberg. View Abstract
Antenatal screening for rubella-infection or immunity? View Abstract
Positioning of long lines. View Abstract
Practical management of hyperinsulinism in infancy. View Abstract
Congenital CMV with callosal lipoma and agenesis. View Abstract
Acute chest syndrome of sickle cell disease. View Abstract
Management and prevention of meningococcal disease. View Abstract
Short-term propofol infusions in children. View Abstract
How To Guide- PICCs in children. Care of the critically ill. Aug 1999 (15.5) View Abstract
Yearbook of Intensive Care and Emergency Medicine published by Springer-Verlag. Ed J. L. Vincent. 2005 View Abstract