Nira Pollock, MD, PhD, MMSc, D(ABMM)
Co-Director, Infectious Diseases Diagnostic Laboratory
Associate Professor of Pathology and Medicine, Harvard Medical School
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Phone
857-218-5113
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Nira Pollock, MD, PhD, MMSc, D(ABMM)
Co-Director, Infectious Diseases Diagnostic Laboratory
Associate Professor of Pathology and Medicine, Harvard Medical School
Medical Services
Languages
English
Professional History
Dr. Pollock is the Co-Director of the Infectious Diseases Diagnostic Laboratory (IDDL) in the Department of Laboratory Medicine at Boston Children’s Hospital. She previously was the Associate Medical Director of the IDDL and has been at BCH since 2012. She is also a faculty member of the Division of Infectious Diseases at BIDMC. She is an Associate Professor of both Pathology and Medicine at Harvard Medical School.
Dr. Pollock completed her MD/PhD at the University of California, San Francisco; her medical residency at Brigham and Women’s Hospital in Boston; and her infectious diseases/clinical microbiology fellowships at Beth Israel Deaconess Medical Center (BIDMC) in Boston.
Publications
Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions in C. difficile infection (CDI), asymptomatic carriage and non-CDI diarrhea. View Abstract
A compartmentalization-free microfluidic digital assay for detecting picogram levels of protein analytes. View Abstract
Towards diagnostic preparedness: detection of highly pathogenic avian influenza A(H5N1) in contrived nasal swab specimens using rapid antigen and point-of-care molecular tests. View Abstract
A digital microfluidic approach to increasing sample volume and reducing bead numbers in single molecule array assays. View Abstract
Comparative effectiveness of metronidazole and vancomycin for treatment of Clostridioides difficile infection in hospitalized children. View Abstract
Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection. View Abstract
Detection of Mycobacterium tuberculosis transrenal DNA in urine samples among adults in Peru. View Abstract
Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests: rationale and guidance for future research. View Abstract
Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection. View Abstract
Clinical accuracy of instrument-based SARS-CoV-2 antigen diagnostic tests: a systematic review and meta-analysis. View Abstract
Testing for SARS-CoV-2: lessons learned and current use cases. View Abstract
Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant. View Abstract
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs. View Abstract
Comparing SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing/self-sampling with molecular and professional-use tests: a systematic review and meta-analysis. View Abstract
Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants. View Abstract
Prevalence and Risk Factors for School-Associated Transmission of SARS-CoV-2. View Abstract
Detection of Mycobacterium tuberculosis transrenal DNA in urine samples among adult patients in Peru. View Abstract
Evaluation of "Test to Return" after COVID-19 Diagnosis in a Massachusetts Public School District. View Abstract
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs. View Abstract
Reply to Ito. View Abstract
Similar SARS-CoV-2 Ct Value Distributions in Anterior Nares versus Nasopharyngeal Samples from Symptomatic Children during Delta and Omicron Surges. View Abstract
Preservation of the Innate Immune Response to Clostridioides difficile Infection in Hospitalized Immunocompromised Patients. View Abstract
Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants. View Abstract
Stool Interleukin-1ß Differentiates Clostridioides difficile Infection (CDI) From Asymptomatic Carriage and Non-CDI Diarrhea. View Abstract
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection. View Abstract
Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection. View Abstract
Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age. View Abstract
Measurement of Severe Acute Respiratory Syndrome Coronavirus 2 Antigens in Plasma of Pediatric Patients With Acute Coronavirus Disease 2019 or Multisystem Inflammatory Syndrome in Children Using an Ultrasensitive and Quantitative Immunoassay. View Abstract
Predictive Value of Isolated Symptoms for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children Tested During Peak Circulation of the Delta Variant. View Abstract
A Multicenter Clinical Diagnostic Accuracy Study of SureStatus, an Affordable, WHO Emergency Use-Listed, Rapid, Point-Of-Care Antigen-Detecting Diagnostic Test for SARS-CoV-2. View Abstract
Analysis of Intestinal Mycobiota of Patients with Clostridioides difficile Infection among a Prospective Inpatient Cohort. View Abstract
Ultrasensitive and Quantitative Toxin Measurement Correlates With Baseline Severity, Severe Outcomes, and Recurrence Among Hospitalized Patients With Clostridioides difficile Infection. View Abstract
Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: An updated systematic review and meta-analysis with meta-regression analyzing influencing factors. View Abstract
Don't forget about human factors: Lessons learned from COVID-19 point-of-care testing. View Abstract
Where is Omicron? Comparison of SARS-CoV-2 RT-PCR and Antigen Test Sensitivity at Commonly Sampled Anatomic Sites Over the Course of Disease. View Abstract
Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: A multi-centre clinical evaluation. View Abstract
Measurement of SARS-CoV-2 antigens in plasma of pediatric patients with acute COVID-19 or MIS-C using an ultrasensitive and quantitative immunoassay. View Abstract
Pediatric Clostridioides difficile Infection: Diagnosis and Diagnostic Stewardship. View Abstract
Detection of Borrelia burgdorferi Cell-free DNA in Human Plasma Samples for Improved Diagnosis of Early Lyme Borreliosis. View Abstract
Implementation of SARS-CoV2 Screening in K-12 Schools Using In-School Pooled Molecular Testing and Deconvolution by Rapid Antigen Test. View Abstract
Evaluation of accuracy, exclusivity, limit-of-detection and ease-of-use of LumiraDx™: An antigen-detecting point-of-care device for SARS-CoV-2. View Abstract
Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis. View Abstract
Lessons Learned From Implementation of SARS-CoV-2 Screening in K-12 Public Schools in Massachusetts. View Abstract
Humoral Immune Response to Clostridioides difficile Toxins A and B in Hospitalized Immunocompromised Patients With C difficile Infection. View Abstract
The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2-Evaluation of the accuracy and ease-of-use. View Abstract
Performance and Operational Evaluation of the Access Bio CareStart Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts. View Abstract
The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change. View Abstract
Performance of Saliva, Oropharyngeal Swabs, and Nasal Swabs for SARS-CoV-2 Molecular Detection: a Systematic Review and Meta-analysis. View Abstract
Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts. View Abstract
Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay. View Abstract
Considerations for Assessment and Deployment of Rapid Antigen Tests for Diagnosis of Coronavirus Disease 2019. View Abstract
Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage. View Abstract
To Test, Perchance to Diagnose: Practical Strategies for Severe Acute Respiratory Syndrome Coronavirus 2 Testing. View Abstract
Integrating gut microbiome and host immune markers to understand the pathogenesis of Clostridioides difficile infection. View Abstract
Molecular detection of Mycobacterium tuberculosis from buccal swabs among adult in Peru. View Abstract
Comparison of Upper Respiratory Viral Load Distributions in Asymptomatic and Symptomatic Children Diagnosed with SARS-CoV-2 Infection in Pediatric Hospital Testing Programs. View Abstract
Absence of Toxemia in Clostridioides difficile Infection: Results from Ultrasensitive Toxin Assay of Serum. View Abstract
Detection of Mycobacterium Tuberculosis DNA in Buccal Swab Samples from Children in Lima, Peru. View Abstract
Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria. View Abstract
Laxative Use Does Not Preclude Diagnosis or Reduce Disease Severity in Clostridiodes difficile Infection. View Abstract
Assessment of the Clinical Utility of Plasma Metagenomic Next-Generation Sequencing in a Pediatric Hospital Population. View Abstract
Toxin A-Predominant Pathogenic Clostridioides difficile: A Novel Clinical Phenotype. View Abstract
Host Immune Markers Distinguish Clostridioides difficile Infection From Asymptomatic Carriage and Non-C. difficile Diarrhea. View Abstract
Rapid electrostatic DNA enrichment for sensitive detection of Trichomonas vaginalis in clinical urinary samples. View Abstract
Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update. View Abstract
Detection of mycobacterial lipoarabinomannan in serum for diagnosis of active tuberculosis. View Abstract
Correction to: Detection of Mycobacterium tuberculosis in pediatric stool samples using TruTip technology. View Abstract
Detection of Mycobacterium tuberculosis in pediatric stool samples using TruTip technology. View Abstract
Comparison of Clostridioides difficile Stool Toxin Concentrations in Adults With Symptomatic Infection and Asymptomatic Carriage Using an Ultrasensitive Quantitative Immunoassay. View Abstract
Assessing the Burden of Clostridium difficile Infection in Low- and Middle-Income Countries. View Abstract
Discovery of a unique Mycobacterium tuberculosis protein through proteomic analysis of urine from patients with active tuberculosis. View Abstract
The Cost-effectiveness of a Point-of-Care Paper Transaminase Test for Monitoring Treatment of HIV/TB Co-Infected Persons. View Abstract
A novel device for collecting and dispensing fingerstick blood for point of care testing. View Abstract
Clinical Utility of Preimplantation Homograft Cultures in Patients Undergoing Congenital Cardiac Surgery. View Abstract
Erysipelothrix rhusiopathiae Suppurative Arthritis in a 12-year-old Boy After an Unusual Fresh Water Exposure. View Abstract
Evaluating Novel Diagnostics in an Outbreak Setting: Lessons Learned from Ebola. View Abstract
Diagnosis of Ebola Virus Disease: Past, Present, and Future. View Abstract
Performance of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone: A Field Evaluation Study. View Abstract
Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection. View Abstract
Field Laboratory Evaluation of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone. View Abstract
ReEBOV Antigen Rapid Test kit for Ebola - Authors' reply. View Abstract
The Positive Predictive Value of Lyme Elisa for the Diagnosis of Lyme Disease in Children. View Abstract
Development of an automated on-chip bead-based ELISA platform. View Abstract
Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool. View Abstract
Paper-Based RNA Extraction, in Situ Isothermal Amplification, and Lateral Flow Detection for Low-Cost, Rapid Diagnosis of Influenza A (H1N1) from Clinical Specimens. View Abstract
ReEBOV Antigen Rapid Test kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study. View Abstract
Performance of an Optimized Paper-Based Test for Rapid Visual Measurement of Alanine Aminotransferase (ALT) in Fingerstick and Venipuncture Samples. View Abstract
Differential immunodetection of toxin B from highly virulent Clostridium difficile BI/NAP-1/027. View Abstract
Challenges in the development of an immunochromatographic interferon-gamma test for diagnosis of pleural tuberculosis. View Abstract
Interferon ?-release assays for diagnosis of latent tuberculosis in healthcare workers in low-incidence settings: pros and cons. View Abstract
Field evaluation of a prototype paper-based point-of-care fingerstick transaminase test. View Abstract
Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis. View Abstract
A point-of-care paper-based fingerstick transaminase test: toward low-cost "lab-on-a-chip" technology for the developing world. View Abstract
A Disposable Microfluidic Virus Concentration Device Based on Evaporation and Interfacial Tension. View Abstract
Validation of Mycobacterium tuberculosis Rv1681 protein as a diagnostic marker of active pulmonary tuberculosis. View Abstract
A point-of-care paper-based fingerstick transaminase test: toward low-cost "lab-on-a-chip" technology for the developing world View Abstract
Validation of Mycobacterium tuberculosis Rv1681 protein as a diagnostic marker of active pulmonary tuberculosis View Abstract
A paper-based multiplexed transaminase test for low-cost, point-of-care liver function testing. View Abstract
Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens. View Abstract
Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens View Abstract
Low yield of chest radiography in a large tuberculosis screening program. View Abstract
Ruling out novel H1N1 influenza virus infection with direct fluorescent antigen testing. View Abstract
Evaluation of the effect of treatment of latent tuberculosis infection on QuantiFERON-TB gold assay results. View Abstract
Discordant QuantiFERON-TB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution? View Abstract
Development of a Novel Urine Antigen Detection Test for Active Tuberculosis View Abstract
Identification and characterization of Mycobacterium tuberculosis antigens in urine of patients with active pulmonary tuberculosis: an innovative and alternative approach of antigen discovery of useful microbial molecules. View Abstract
Identification of Mycobacterium tuberculosis ornithine carboamyltransferase in urine as a possible molecular marker of active pulmonary tuberculosis. View Abstract
Screening Health Care Workers (HCW) with Quantiferon-Gold: Possible False Negative Results in HCW with High Pre-Test Probability of Latent Tuberculosis Infection View Abstract
Specimen dilution increases the diagnostic utility of the gen-probe mycobacterium tuberculosis direct test. View Abstract
Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium. View Abstract
Reconstitution of Microtubule-based Organelle Transport Using Factors Purified from Dictyostelium View Abstract
In vitro microtubule-based organelle transport in wild-type Dictyostelium and cells overexpressing a truncated dynein heavy chain. View Abstract
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