Nutan Sharma, MD, PhD

Affiliate Neurologist, Department of Neurology

Associate Professor of Neurology, Harvard Medical School

NPI 1700867975

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Nutan Sharma, MD, PhD

Affiliate Neurologist, Department of Neurology

Associate Professor of Neurology, Harvard Medical School

Medical Services

Languages

English

Education

Undergraduate School

Stanford University

1986

Stanford

Graduate School

SUNY at Stony Brook

1995

Stony Brook

Medical School

SUNY at Stony Brook

1995

Stony Brook

Internship

Internal Medicine

Northwestern University

1996

Evanston

Residency

Neurology

Yale University

1999

New Haven

Fellowship

Movement Disorders

Boston Children's Hospital

2001

Boston

Certifications

American Board of Psychiatry and Neurology (Neurology)

Professional History

Dr. Sharma is a clinician scientist specializing in movement disorders, with a special expertise in dystonia. Dr. Sharma provides diagnostic evaluation and treatment for children with movement disorders.

Approach to Care

I am focused on understanding the causes of brain-driven movement disorders, across the lifespan. I work in close collaboration with my basic science colleagues to understand the genetics underlying movement disorders and the way in which the brain controls movement.

Publications

Globally Reduced Brain Volume in Rett Syndrome. View Abstract

KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. View Abstract

Non-invasive detection of allele-specific CRISPR-SaCas9-KKH disruption of TOR1A DYT1 allele in a xenograft mouse model. View Abstract

Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders. View Abstract

Efficacy and Safety of Sodium Oxybate in Isolated Focal Laryngeal Dystonia: A Phase IIb Double-Blind Placebo-Controlled Cross-Over Randomized Clinical Trial. View Abstract

Dysphagia is a risk factor of malnutrition in X-linked Dystonia-Parkinsonism. View Abstract

Genetic Risk Factors in Isolated Dystonia Escape Genome-Wide Association Studies. View Abstract

Neurological disorders caused by novel non-coding repeat expansions: clinical features and differential diagnosis. View Abstract

Motor assessment of X-linked dystonia parkinsonism via machine-learning-based analysis of wearable sensor data. View Abstract

The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. View Abstract

Sex Differences in People with Tourette Syndrome and Persistent Motor or Vocal Tic Disorder in the Tourette Association of America International Consortium for Genetics Database. View Abstract

Oral diadochokinetic markers of X-linked dystonia-parkinsonism. View Abstract

In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments. View Abstract

Editorial: Current opinions in neurology editorial. View Abstract

Establishing a natural history of X-linked dystonia parkinsonism. View Abstract

Dystonias: Clinical Recognition and the Role of Additional Diagnostic Testing. View Abstract

Sustained activation in basal ganglia and cerebellum after repetitive movement in a non-task-specific dystonia. View Abstract

Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with impaired ganglioside synthesis. View Abstract

DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. View Abstract

Correction to: Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. View Abstract

Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat. View Abstract

Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin. View Abstract

Speech and swallowing deficits in X-Linked Dystonia-Parkinsonism. View Abstract

A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy. View Abstract

Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism. View Abstract

Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities. View Abstract

The dystonia gene THAP1 controls DNA double-strand break repair choice. View Abstract

Hyperkinetic Movements in Children: Differential Diagnosis, Evaluation, and Treatment. View Abstract

Functional dystonia: A case-control study and risk prediction algorithm. View Abstract

Functional Dystonia: Differentiation From Primary Dystonia and Multidisciplinary Treatments. View Abstract

SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene. View Abstract

Progressive Decline in Voice and Voice-Related Quality of Life in X-Linked Dystonia Parkinsonism. View Abstract

KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation. View Abstract

Cautionary notes on diagnosing functional neurologic disorder as a neurologist-in-training. View Abstract

Isolated Cervical Dystonia: Management and Barriers to Care. View Abstract

Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2a signaling leading to a compromised stress response. View Abstract

TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X-linked Dystonia-Parkinsonism. View Abstract

Editorial: Advances in rare movement disorders. View Abstract

Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex. View Abstract

Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort. View Abstract

Advances in rare movement disorders. View Abstract

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function. View Abstract

Phasic Knee Bending Dystonic and Parkinsonian Gait: A Characteristic Finding in X-Linked Dystonia Parkinsonism. View Abstract

Defining research priorities in dystonia. View Abstract

X-Linked Dystonia-Parkinsonism: recent advances. View Abstract

White Matter Changes in Cervical Dystonia Relate to Clinical Effectiveness of Botulinum Toxin Treatment. View Abstract

Voice and swallowing dysfunction in X-linked dystonia parkinsonism. View Abstract

Neuropathology of Dystonia. View Abstract

Functional neurological disorders in Parkinson disease. View Abstract

Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. View Abstract

Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1. View Abstract

Low CSF 5-HIAA in Myoclonus Dystonia. View Abstract

A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. View Abstract

Neuropsychological and psychiatric outcome of GPi-deep brain stimulation in dystonia. View Abstract

Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. View Abstract

Translational effects and coding potential of an upstream open reading frame associated with DOPA Responsive Dystonia. View Abstract

X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. View Abstract

Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2a Signaling as a Generalizable Mechanism for Dystonia. View Abstract

Dystonia-Causing Mutations as a Contribution to the Etiology of Spasmodic Dysphonia. View Abstract

Thalamic Volume Is Reduced in Cervical and Laryngeal Dystonias. View Abstract

Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. View Abstract

Beyond Dystonia-Parkinsonism: Chorea and Ataxia with ATP1A3 Mutations. View Abstract

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. View Abstract

Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. View Abstract

Dopamine receptor and Ga(olf) expression in DYT1 dystonia mouse models during postnatal development. View Abstract

Update on treatments for dystonia. View Abstract

Clinical neurogenetics: dystonia from phenotype to genotype. View Abstract

Pallidal deep brain stimulation for dystonia: a case series. View Abstract

Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region. View Abstract

Lysosomal enzyme defects and Parkinson disease. View Abstract

EDITORIAL: Advances in Dystonia. View Abstract

Mutations in GNAL cause primary torsion dystonia. View Abstract

Neurogenesis and neuronal migration in the forebrain of the TorsinA knockout mouse embryo. View Abstract

Evidence for altered basal ganglia-brainstem connections in cervical dystonia. View Abstract

Deep brain stimulation for medically refractory life-threatening status dystonicus in children. View Abstract

Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. View Abstract

Mutation in 5' upstream region of GCHI gene causes familial dopa-responsive dystonia. View Abstract

Consideration of genetic contributions to the risk for spasmodic dysphonia. View Abstract

Extrapyramidal epilepsy. View Abstract

Molecular pathways in dystonia. View Abstract

Genetic evidence for an association of the TOR1A locus with segmental/focal dystonia. View Abstract

Function of dopamine transporter is compromised in DYT1 transgenic animal model in vivo. View Abstract

Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. View Abstract

Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia. View Abstract

Gene Repression or Imprinting: Rett Syndrome View Abstract

Effectiveness of Botulinum Toxin in the Treatment of Movement Disorders View Abstract

Parkinson's disease View Abstract

Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration. View Abstract

Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp View Abstract

Dopamine release is impaired in a mouse model of DYT1 dystonia. View Abstract

Patient Preference in Botulinum Toxin for Writer’s Cramp View Abstract

Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. View Abstract

White matter abnormalities in dystonia normalize after botulinum toxin treatment. View Abstract

Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. View Abstract

Rodent models for dystonia research: characteristics, evaluation, and utility. View Abstract

DYT1 Transgenic Mouse View Abstract

Parkinson's disease and the Family View Abstract

Botulinum Toxin A Reduces Drooling in Neurodegenerative Diseases View Abstract

Dopa-Responsive Dystonia Manifesting as Markedly Different Phenotypes in Monozygotic Twins View Abstract

Progressive Supranuclear Palsy View Abstract

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation. View Abstract

Inherited movement disorders. View Abstract

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. View Abstract

Neuroprotective Strategies in Parkinson's Disease View Abstract

Parkinson's View Abstract

Blackwell's Underground Clinical Vignettes, Neurology View Abstract

Movement Disorders in Pregnancy View Abstract

Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. View Abstract

A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. View Abstract

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations. View Abstract

Neurology Classic Clinical Cases for USMLE Step 2 and Clerkship Review View Abstract

Neurology View Abstract

Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells. View Abstract

Characterization of Kv2.1 in PC12 cells View Abstract

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