Ofer Levy, MD, PhD
Director, Precision Vaccines Program; Senior Physician in Pediatrics, Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
Image
Ofer Levy, MD, PhD
Director, Precision Vaccines Program; Senior Physician in Pediatrics, Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Hebrew
Education
Medical School
New York University
1996
New York
NY
Graduate School
New York University
1997
New York
NY
Internship
Pediatrics
Boston Children's Hospital
1998
Boston
MA
Residency
Pediatrics
Boston Children's Hospital
2000
Boston
MA
Fellowship
Pediatric Infectious Disease
Boston Children's Hospital
2003
Boston
MA
Media
On Answers
A new vaccine formulation could finally protect babies against RSV
Certifications
American Board of Pediatrics (Infectious Diseases)
Publications
High affinity CD16 polymorphism associated with reduced risk of severe COVID-19. View Abstract
Vaccinology: Getting our modernization act together. View Abstract
Safety and implementation of phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns. View Abstract
Correction: Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways. View Abstract
Network analysis reveals protein modules associated with childhood respiratory diseases. View Abstract
Product and trial design considerations on the path towards a vaccine to combat opioid overdose. View Abstract
Identification of a multi-omics factor predictive of long COVID in the IMPACC study. View Abstract
BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice. View Abstract
Pre-vaccination immune markers predict response to BNT162b2 mRNA vaccine in vulnerable groups - The CONVERS project, report from a pediatric tertiary hospital. View Abstract
Fostering Collaboration Across Nations: Report of the 6th International Neonatal and Maternal Immunization Symposium (INMIS), Costa Rica, 2024. View Abstract
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients. View Abstract
Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay. View Abstract
Biomarkers of vaccine safety and efficacy in vulnerable populations: Lessons from the fourth international precision vaccines conference. View Abstract
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping. View Abstract
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19. View Abstract
Predictive gene expression signature diagnoses neonatal sepsis before clinical presentation. View Abstract
Safety and implementation of a phase 1 randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns. View Abstract
The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo. View Abstract
Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life. View Abstract
Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings. View Abstract
DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life. View Abstract
Precision adjuvants for pediatric vaccines. View Abstract
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70. View Abstract
Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life. View Abstract
Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl. View Abstract
From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation. View Abstract
Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways. View Abstract
Network Analysis Reveals Protein Modules Associated with Childhood Respiratory Diseases. View Abstract
BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice. View Abstract
Heterologous SARS-CoV-2 booster vaccine for individuals with hematological malignancies after a primary SARS-CoV-2 mRNA vaccine series. View Abstract
Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro. View Abstract
Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes. View Abstract
Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality. View Abstract
Editorial: Precision vaccinology for infectious diseases. View Abstract
Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology. View Abstract
Respiratory Infection- and Asthma-prone, Low Vaccine Responder Children Demonstrate Distinct Mononuclear Cell DNA Methylation Pathways. View Abstract
Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders. View Abstract
Author Correction: Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. View Abstract
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. View Abstract
Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. View Abstract
Modeling human immune responses to vaccination in vitro. View Abstract
Host-Microbe Multi-omic Profiling Identifies a Unique Program of COVID-19 Inflammatory Dysregulation in Solid Organ Transplant Recipients. View Abstract
Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants. View Abstract
Early cellular and molecular signatures correlate with severity of West Nile virus infection. View Abstract
Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208]. View Abstract
Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen. View Abstract
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. View Abstract
Severe congenital neutropenia due to jagunal homolog 1 (JAGN1) mutation: a case report and literature review. View Abstract
A protocol for high-throughput screening for immunomodulatory compounds using human primary cells. View Abstract
Elevated third trimester corticosteroid levels are associated with fewer offspring infections. View Abstract
Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations. View Abstract
Effective early antiretroviral therapy in perinatal-HIV infection reduces subsequent plasma inflammatory profile. View Abstract
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. View Abstract
Integrative systems biology characterizes immune-mediated neurodevelopmental changes in murine Zika virus microcephaly. View Abstract
A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics. View Abstract
Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. View Abstract
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. View Abstract
The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo. View Abstract
Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection. View Abstract
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. View Abstract
Reduced Steroid Metabolites Identify Infection-Prone Children in Two Independent Pre-Birth Cohorts. View Abstract
A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells. View Abstract
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses. View Abstract
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. View Abstract
The Immune Signatures data resource, a compendium of systems vaccinology datasets. View Abstract
Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination. View Abstract
A Parallelization Strategy for the Time Efficient Analysis of Thousands of LC/MS Runs in High-Performance Computing Environment. View Abstract
Ruxolitinib for Refractory Macrophage Activation Syndrome Complicating Adult-Onset Still's Disease. View Abstract
Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers. View Abstract
Immunogenicity of a Three-Dose Primary Series of mRNA COVID-19 Vaccines in Patients With Lymphoid Malignancies. View Abstract
Advancing the Science of Vaccine Safety During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond: Launching an International Network of Special Immunization Services. View Abstract
Perinatally Human Immunodeficiency Virus-Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity. View Abstract
Precision Vaccine Adjuvants for Older Adults: A Scoping Review. View Abstract
A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations. View Abstract
Precision Vaccines: Lessons Learned From the Coronavirus Pandemic. View Abstract
Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines: Perceptions and Attitudes From the Food and Drug Administration Public Commentary. View Abstract
Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making. View Abstract
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. View Abstract
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. View Abstract
CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns. View Abstract
Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells. View Abstract
Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro. View Abstract
Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy. View Abstract
Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review. View Abstract
An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. View Abstract
An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. View Abstract
BCG vaccine's off-target effects on allergic, inflammatory, and autoimmune diseases: Worth another shot? View Abstract
Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life. View Abstract
SARS-CoV-2 mRNA Vaccine Attitudes as Expressed in U.S. FDA Public Commentary: Need for a Public-Private Partnership in a Learning Immunization System. View Abstract
Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro. View Abstract
Bell's palsy and SARS-CoV-2 vaccines-an unfolding story - Authors' reply. View Abstract
Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life. View Abstract
Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. View Abstract
Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g. View Abstract
Considering Mandatory Vaccination of Children for COVID-19. View Abstract
Bell's palsy and SARS-CoV-2 vaccines. View Abstract
The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation. View Abstract
Vaccination of Term and Preterm Infants. View Abstract
Integrative Metabolomics to Identify Molecular Signatures of Responses to Vaccines and Infections. View Abstract
Corrigendum: Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea. View Abstract
Ensuring vaccine safety. View Abstract
Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. View Abstract
Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. View Abstract
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference. View Abstract
A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues. View Abstract
A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium. View Abstract
Posterior shoulder fracture-dislocation: A systematic review of the literature and current aspects of management. View Abstract
Electromyographic analysis of selected shoulder muscles during a series of exercises commonly used in patients with symptomatic degenerative rotator cuff tears. View Abstract
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. View Abstract
Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea. View Abstract
Staphylococcus epidermidis Sensitizes Perinatal Hypoxic-Ischemic Brain Injury in Male but Not Female Mice. View Abstract
Early antiretroviral therapy-treated perinatally HIV-infected seronegative children demonstrate distinct long-term persistence of HIV-specific T-cell and B-cell memory. View Abstract
Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance. View Abstract
BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny. View Abstract
Vancomycin Is Protective in a Neonatal Mouse Model of Staphylococcus epidermidis-Potentiated Hypoxic-Ischemic Brain Injury. View Abstract
The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice. View Abstract
Toward precision adjuvants: optimizing science and safety. View Abstract
Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation. View Abstract
Immunological mechanisms of inducing HIV immunity in infants. View Abstract
Immunometabolic approaches to prevent, detect, and treat neonatal sepsis. View Abstract
Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro. View Abstract
Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities. View Abstract
AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition. View Abstract
OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines. View Abstract
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. View Abstract
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. View Abstract
Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro. View Abstract
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. View Abstract
Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro. View Abstract
The Fourth International Neonatal and Maternal Immunization Symposium (INMIS 2017): Toward Integrating Maternal and Infant Immunization Programs. View Abstract
First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines. View Abstract
Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future. View Abstract
Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut. View Abstract
Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro. View Abstract
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. View Abstract
A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation. View Abstract
Neonatal Immunization: Rationale, Current State, and Future Prospects. View Abstract
Hepatic Legionella pneumophila Infection in an Infant With Severe Combined Immunodeficiency. View Abstract
Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. View Abstract
Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization. View Abstract
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation. View Abstract
Stemless Prosthesis for Total Shoulder Arthroplasty. View Abstract
The "Parachute" Technique: A Simple and Effective Single-Row Procedure to Achieve an Increased Contact Area Between the Cuff-Tendon and Its Footprint. View Abstract
The "Purse String" Procedure for Recurrent Anterior Glenohumeral Instability: A Simple Technique to Achieve Bankart Repair, Capsular Shift, and a Good Labral Bumper. View Abstract
Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases. View Abstract
Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis. View Abstract
Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. View Abstract
TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. View Abstract
Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny. View Abstract
The "Purse-string" Technique for Shoulder Stabilization, Description of the Technique, Long term Results and Literature Review. View Abstract
Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. View Abstract
A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity. View Abstract
Human newborn B cells mount an interferon-a/ß receptor-dependent humoral response to respiratory syncytial virus. View Abstract
Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. View Abstract
Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities. View Abstract
"Owl" Technique for All-Arthroscopic Augmentation of a Massive or Large Rotator Cuff Tear With Extracellular Matrix Graft. View Abstract
Complications of Hip Arthroscopy: Patient Perspectives. View Abstract
Heterologous vaccine effects. View Abstract
Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells. View Abstract
Harnessing the beneficial heterologous effects of vaccination. View Abstract
Use of cidofovir in pediatric patients with adenovirus infection. View Abstract
In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. View Abstract
The impact of concomitant fibromyalgia on visual analogue scales of pain, fatigue and function in patients with various rheumatic disorders. View Abstract
Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage. View Abstract
Changing oral vaccine to inactivated polio vaccine might increase mortality. View Abstract
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. View Abstract
Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation. View Abstract
Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox. View Abstract
Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs. View Abstract
The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. View Abstract
Systems vaccinology: a promise for the young and the poor. View Abstract
Staphylococcus epidermidis Bacteremia Induces Brain Injury in Neonatal Mice via Toll-like Receptor 2-Dependent and -Independent Pathways. View Abstract
Ready to benefit from training: heterologous effects of early life immunization. View Abstract
Soluble mediators regulating immunity in early life. View Abstract
The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells. View Abstract
Thoracoscapular Fusion for Winging of the Scapula with Screw Fixation for Fascioscapulohumeral Dystrophy (Modified Copeland-Howard Procedure). View Abstract
Infection-induced inflammation and cerebral injury in preterm infants. View Abstract
Ontogeny of early life immunity. View Abstract
Tocilizumab in adult-onset Still's disease: the Israeli experience. View Abstract
A prime time for trained immunity: innate immune memory in newborns and infants. View Abstract
Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity. View Abstract
Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines. View Abstract
Identification of single nucleotide polymorphisms in hematopoietic cell transplant patients affecting early recognition of, and response to, endotoxin. View Abstract
Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine. View Abstract
Neonatal host defense against Staphylococcal infections. View Abstract
Vaccine-induced immunity in early life. View Abstract
Management of first-time dislocations of the shoulder in patients older than 40 years: the prevalence of iatrogenic fracture. View Abstract
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. View Abstract
Role of innate immunity in neonatal infection. View Abstract
Plasma-mediated immune suppression: a neonatal perspective. View Abstract
Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly. View Abstract
Immune response to vaccine adjuvants during the first year of life. View Abstract
A neonatal model of intravenous Staphylococcus epidermidis infection in mice <24 h old enables characterization of early innate immune responses. View Abstract
Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation. View Abstract
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. View Abstract
Responsiveness of human monocytes to the commensal bacterium Staphylococcus epidermidis develops late in gestation. View Abstract
Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors. View Abstract
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. View Abstract
Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake. View Abstract
Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy. View Abstract
Development of newborn and infant vaccines. View Abstract
17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. View Abstract
Systemic stimulation of TLR2 impairs neonatal mouse brain development. View Abstract
"Put your 'extended' finger on the bleeder": the use of direct pressure from the shaver blade to achieve hemostasis. View Abstract
Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants. View Abstract
Challenges in infant immunity: implications for responses to infection and vaccines. View Abstract
Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities. View Abstract
Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo. View Abstract
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. View Abstract
Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis. View Abstract
Role of innate host defenses in susceptibility to early-onset neonatal sepsis. View Abstract
TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. View Abstract
Neonatal innate immunity in allergy development. View Abstract
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. View Abstract
Neonatal vaccination: a once in a lifetime opportunity. View Abstract
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept. View Abstract
Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates. View Abstract
The active elevation lag sign and the triangle sign: new clinical signs of trapezius palsy. View Abstract
Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. View Abstract
Safety and efficacy of neonatal vaccination. View Abstract
Novel vaccines: bridging research, development and production. View Abstract
Bactericidal/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. View Abstract
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. View Abstract
The role of anterior deltoid reeducation in patients with massive irreparable degenerative rotator cuff tears. View Abstract
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. View Abstract
Immunostimulatory activity of Toll-like receptor 8 agonists towards human leucocytes: basic mechanisms and translational opportunities. View Abstract
Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI. View Abstract
Bactericidal/permeability-increasing protein in host defense and its efficacy in the treatment of bacterial sepsis. View Abstract
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. View Abstract
Neonatal immune responses to coagulase-negative staphylococci. View Abstract
Innate immunity of the newborn: basic mechanisms and clinical correlates. View Abstract
Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. View Abstract
Subacromial plica as a cause of impingement in the shoulder. View Abstract
TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs. View Abstract
The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn. View Abstract
Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. View Abstract
Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. View Abstract
Neonatal babesiosis: case report and review of the literature. View Abstract
Functional and biochemical characterization of epithelial bactericidal/permeability-increasing protein. View Abstract
Posttraumatic locked dislocation of congenital pseudarthrosis of the clavicle. View Abstract
Geometrical analysis of Copeland surface replacement shoulder arthroplasty in relation to normal anatomy. View Abstract
Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. View Abstract
Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists. View Abstract
Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. View Abstract
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. View Abstract
Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes. View Abstract
Cementless surface replacement arthroplasty (Copeland CSRA) for osteoarthritis of the shoulder. View Abstract
Copeland surface replacement arthroplasty of the shoulder in rheumatoid arthritis. View Abstract
Genetic screening for susceptibility to infection in the NICU setting. View Abstract
Mechanical properties of regenerated coracoacromial ligament after subacromial decompression. View Abstract
Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release. View Abstract
Endotoxemia and elevation of lipopolysaccharide-binding protein after hematopoietic stem cell transplantation. View Abstract
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. View Abstract
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. View Abstract
Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. View Abstract
Disseminated varicella infection due to vaccine (Oka) strain varicella zoster virus in a patient with a novel deficiency in natural killer T cells View Abstract
Endotoxemia and elevation of lipopolysachharide-binding protein after hematopoietic stem cell transplantation View Abstract
Newborn cord blood demonstrates impaired TNF responses to multiple pathogen-assocaited molecular pattern molecules (PAMPs) despite normal expression of monocyte Toll-like receptos 1 and 2, MD-2, MyD88 and TIRAP View Abstract
Journeys in the study of antibacterial host defenses: Conserved mechanisms, evolving insights and potential therapeutic opportunities [review] View Abstract
Expression of BPI by human mucosal epithelia [review] View Abstract
Simple, minimally invasive surgical technique for treatment of type 2 fractures of the distal clavicle. View Abstract
The vertical-apical suture Bankart lesion repair for anteroinferior glenohumeral instability. View Abstract
Impaired innate immunity at birth: deficiency of bactericidal/permeability-increasing protein (BPI) in the neutrophils of newborns. View Abstract
Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils. View Abstract
The role of arthroscopy for the problem shoulder arthroplasty. View Abstract
Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. View Abstract
Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. View Abstract
Therapeutic potential of the bactericidal/permeability-increasing protein. View Abstract
Lipid-mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia View Abstract
Fatal disseminated Candida lusitania infection in an infant with chronic granulomatous disease View Abstract
BPI in host defense and its efficacy in the treatment of bacterial sepsis [review] View Abstract
A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein. View Abstract
Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents. View Abstract
Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivo. View Abstract
A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein [review] View Abstract
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. View Abstract
Oxygen-independent antimicrobial systems of phagocytes View Abstract
Therapeutic uses of BPI protein products in BPI-deficient humans View Abstract
Antibiotic proteins of polymorphonuclear leukocytes. View Abstract
Antibacterial 15 kDa protein isoforms (p15s) of rabbit polymorphonuclear leukocytes View Abstract
Antibacterial proteins of granulaocytes differ in interaction with endotoxin: comparison of BPI, p15s, and defensins View Abstract
Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein (BPI) and p15s in an evolving sterile rabbit peritoneal inflammatory exudate View Abstract
Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli. View Abstract
Integration of antimicrobial host defenses against Gram-negative bacteria [review] View Abstract
Antibacterial 15 kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins View Abstract
Structural characterization of BPI-modulating 15 kDa proteins from rabbit polymorphonuclear leukocytes: identification of a novel family of leukocyte proteins. View Abstract
Isolation of two isoforms of a novel 15 kDa protein from rabbit polymorphonuclear leukocytes that modulates the antibacterial actions of other leukocyte proteins View Abstract
Locations