Orah Platt, MD
Chief, Department of Laboratory Medicine
Professor of Pediatrics, Harvard Medical School
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Orah Platt, MD
Chief, Department of Laboratory Medicine
Professor of Pediatrics, Harvard Medical School
Medical Services
Education
Internship
Massachusetts General Hospital
Boston
MA
Medical School
Harvard Medical School
Boston
MA
Residency
Massachusetts General Hospital
Boston
MA
Fellowship
Boston Children's Hospital
Boston
MA
Publications
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort. View Abstract
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. View Abstract
Age- and gender-dependent obesity in individuals with 16p11.2 deletion. View Abstract
Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy. View Abstract
Pulmonary hypertension and nitric oxide depletion in sickle cell disease. View Abstract
Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss. View Abstract
SLC26A4 c.919-2A>G varies among Chinese ethnic groups as a cause of hearing loss. View Abstract
Hydroxyurea for the treatment of sickle cell anemia. View Abstract
Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice. View Abstract
Association between microdeletion and microduplication at 16p11.2 and autism. View Abstract
Development of a focused oligonucleotide-array comparative genomic hybridization chip for clinical diagnosis of genomic imbalance. View Abstract
Quantitative trait loci for peripheral blood cell counts: a study in baboons. View Abstract
Quantitative trait loci for baseline erythroid traits. View Abstract
Prevention and management of stroke in sickle cell anemia. View Abstract
Preventing stroke in sickle cell anemia. View Abstract
Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume. View Abstract
Genetic influences on peripheral blood cell counts: a study in baboons. View Abstract
Acquisition of mutans streptococci and caries prevalence in pediatric sickle cell anemia patients receiving long-term antibiotic therapy. View Abstract
Use of a multiplex PCR/sequencing strategy to detect both connexin 30 (GJB6) 342 kb deletion and connexin 26 (GJB2) mutations in cases of childhood deafness. View Abstract
Human erythrocyte membrane band 3 protein influences hemoglobin cooperativity. Possible effect on oxygen transport. View Abstract
Effectiveness of sequencing connexin 26 (GJB2) in cases of familial or sporadic childhood deafness referred for molecular diagnostic testing. View Abstract
Sickle cell anemia as an inflammatory disease. View Abstract
The acute chest syndrome of sickle cell disease. View Abstract
Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related. View Abstract
Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. View Abstract
Reticulocyte hemoglobin content to diagnose iron deficiency in children. View Abstract
Silent cerebral infarcts in sickle cell anemia: a risk factor analysis. The Cooperative Study of Sickle Cell Disease. View Abstract
Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. View Abstract
Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity. View Abstract
The febrile child with sickle cell disease: a pediatrician's quandary. View Abstract
Bone marrow transplantation in sickle cell anemia--the dilemma of choice. View Abstract
Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. View Abstract
A high-performance liquid chromatographic assay for the determination of itraconazole concentration using solid-phase extraction and small sample volume. View Abstract
Membrane protein interactions in sickle red blood cells: evidence of abnormal protein 3 function. View Abstract
A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. View Abstract
Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity. View Abstract
Sickle cell paths converge on hydroxyurea. View Abstract
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. View Abstract
Sickle reticulocytes adhere to VCAM-1. View Abstract
Mortality in sickle cell disease. Life expectancy and risk factors for early death. View Abstract
Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. View Abstract
Easing the suffering caused by sickle cell disease. View Abstract
Predicting medical student success in a clinical clerkship by rating students' nonverbal behavior. View Abstract
A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. View Abstract
Effect of context on the rating of students by faculty and housestaff in a clinical clerkship. View Abstract
Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. View Abstract
Pain in sickle cell disease. Rates and risk factors. View Abstract
Toad urinary bladder epithelial cells contain an analogue of cytoskeletal protein 4.1. View Abstract
Reliability of Tanner stage assessments in a multi-center study. View Abstract
Pathology of membrane proteins in sickle erythrocytes. View Abstract
Is there treatment for sickle cell anemia? View Abstract
Membrane protein lesions in erythrocytes with Heinz bodies. View Abstract
Influence of hydroxyurea on fetal hemoglobin production in vitro. View Abstract
Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. View Abstract
Pyruvate kinase deficiency in dog and human erythrocytes: effects of energy depletion on cation composition and cellular hydration. View Abstract
Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. View Abstract
Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes. View Abstract
Loss of adhesion of erythrocyte precursors to fibronectin during erythroid differentiation. View Abstract
Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. View Abstract
Chemotherapy to increase fetal hemoglobin in patients with sickle cell anemia. View Abstract
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. View Abstract
Influence of sickle hemoglobinopathies on growth and development. View Abstract
Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. View Abstract
Exercise-induced hemolysis in sickle cell anemia: shear sensitivity and erythrocyte dehydration. View Abstract
Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. View Abstract
Glycosylation of variant hemoglobins in normal and diabetic subjects. View Abstract
Isobutyl nitrite toxicity by ingestion. View Abstract
Lung function in children with sickle cell anemia. View Abstract
Newborn bleeding disorders: a practical approach. View Abstract
Energy reserve and cation composition of irreversibly sickled cells in vivo. View Abstract
Red blood cell size and glycolytic enzyme activity: relationship to number of intramedullary cell divisions. View Abstract
Haemolytic disorders of infancy. View Abstract
Locations