Paula Watnick, MD, PhD
Senior Physician in Pediatrics. Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
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Paula Watnick, MD, PhD
Senior Physician in Pediatrics. Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Spanish
Education
Graduate School
California Institute of Technology
1988
Pasadena
CA
Medical School
Yale School of Medicine
1991
New Haven
CT
Internship
Internal Medicine
Beth Israel Deaconess Medical Center
1992
Boston
MA
Residency
Internal Medicine
Beth Israel Deaconess Medical Center
1993
Boston
MA
Fellowship
Infectious Diseases
Massachusetts General Hospital
1995
Boston
MA
Certifications
American Board of Internal Medicine (General)
American Board of Internal Medicine (Infectious Diseases)
Publications
The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation. View Abstract
Carbon source, cell density, and the microbial community control inhibition of V. cholerae surface colonization by environmental nitrate. View Abstract
Carbon source, cell density, and the microbial community control inhibition of V. cholerae surface colonization by environmental nitrate. View Abstract
Testosterone treatment impacts the intestinal microbiome of transgender individuals. View Abstract
Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP. View Abstract
Vibrio cholerae high cell density quorum sensing activates the host intestinal innate immune response. View Abstract
Bioengineered 3D Tissue Model of Intestine Epithelium with Oxygen Gradients to Sustain Human Gut Microbiome. View Abstract
The Short-Chain Fatty Acids Propionate and Butyrate Augment Adherent-Invasive Escherichia coli Virulence but Repress Inflammation in a Human Intestinal Enteroid Model of Infection. View Abstract
Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. View Abstract
The Interplay of Sex Steroids, the Immune Response, and the Intestinal Microbiota. View Abstract
Methionine Availability in the Arthropod Intestine Is Elucidated through Identification of Vibrio cholerae Methionine Acquisition Systems. View Abstract
Vibrio cholerae Sheds Its Coat to Make Itself Comfortable in the Gut. View Abstract
Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling. View Abstract
A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae. View Abstract
Removal of a Membrane Anchor Reveals the Opposing Regulatory Functions of Vibrio cholerae Glucose-Specific Enzyme IIA in Biofilms and the Mammalian Intestine. View Abstract
A Self-Assembling Whole-Cell Vaccine Antigen Presentation Platform. View Abstract
The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. View Abstract
Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform. View Abstract
Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. View Abstract
Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide. View Abstract
Erysipelothrix rhusiopathiae Suppurative Arthritis in a 12-year-old Boy After an Unusual Fresh Water Exposure. View Abstract
The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster. View Abstract
Regulation of CsrB/C sRNA decay by EIIA(Glc) of the phosphoenolpyruvate: carbohydrate phosphotransferase system. View Abstract
In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment. View Abstract
The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. View Abstract
The transcription factor Mlc promotes Vibrio cholerae biofilm formation through repression of phosphotransferase system components. View Abstract
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. View Abstract
Mutations in the IMD pathway and mustard counter Vibrio cholerae suppression of intestinal stem cell division in Drosophila. View Abstract
Mannitol and the mannitol-specific enzyme IIB subunit activate Vibrio cholerae biofilm formation. View Abstract
Glucose-specific enzyme IIA has unique binding partners in the vibrio cholerae biofilm. View Abstract
The bacterial biofilm matrix as a platform for protein delivery. View Abstract
The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway. View Abstract
A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. View Abstract
Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation. View Abstract
A communal bacterial adhesin anchors biofilm and bystander cells to surfaces. View Abstract
The phosphoenolpyruvate phosphotransferase system regulates Vibrio cholerae biofilm formation through multiple independent pathways. View Abstract
Vibrio cholerae phosphoenolpyruvate phosphotransferase system control of carbohydrate transport, biofilm formation, and colonization of the germfree mouse intestine. View Abstract
Signals, regulatory networks, and materials that build and break bacterial biofilms. View Abstract
Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. View Abstract
Genetic analysis of Vibrio cholerae monolayer formation reveals a key role for DeltaPsi in the transition to permanent attachment. View Abstract
A novel role for enzyme I of the Vibrio cholerae phosphoenolpyruvate phosphotransferase system in regulation of growth in a biofilm. View Abstract
NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine. View Abstract
Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera. View Abstract
Identification of novel stage-specific genetic requirements through whole genome transcription profiling of Vibrio cholerae biofilm development. View Abstract
Role for glycine betaine transport in Vibrio cholerae osmoadaptation and biofilm formation within microbial communities. View Abstract
Genetic evidence that the Vibrio cholerae monolayer is a distinct stage in biofilm development. View Abstract
The Vibrio cholerae O139 O-antigen polysaccharide is essential for Ca2+-dependent biofilm development in sea water. View Abstract
Role of ectoine in Vibrio cholerae osmoadaptation. View Abstract
Environmental determinants of Vibrio cholerae biofilm development. View Abstract
Identification and characterization of a Vibrio cholerae gene, mbaA, involved in maintenance of biofilm architecture. View Abstract
Vibrio cholerae CytR is a repressor of biofilm development. View Abstract
Paula I Watnick--elucidating the role of biofilms. Interview by Pam Das. View Abstract
The absence of a flagellum leads to altered colony morphology, biofilm development and virulence in Vibrio cholerae O139. View Abstract
Biofilm, city of microbes. View Abstract
Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases. View Abstract
Steps in the development of a Vibrio cholerae El Tor biofilm. View Abstract
A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor. View Abstract
Genetic approaches to study of biofilms. View Abstract
The interaction of the Vibrio cholerae transcription factors, Fur and IrgB, with the overlapping promoters of two virulence genes, irgA and irgB. View Abstract
Purification of Vibrio cholerae fur and estimation of its intracellular abundance by antibody sandwich enzyme-linked immunosorbent assay. View Abstract
Hydrophobic mismatch in gramicidin A'/lecithin systems. View Abstract
Characterization of the transverse relaxation rates in lipid bilayers. View Abstract
Conformations of model peptides in membrane-mimetic environments. View Abstract