Peter E. Newburger, MD
Attending Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Lecturer on Pediatrics (Part-time), Harvard Medical School
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Peter E. Newburger, MD
Attending Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Lecturer on Pediatrics (Part-time), Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Harvard Medical School
1974
Boston
MA
Residency
Boston Children's Hospital
1976
Boston
MA
Fellowship
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
1979
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Hematology-Oncology)
Professional History
Dr. Peter E. Newburger is a physician-scientist focused on caring for patients with non-malignant hematologic disorders with a special interest in diseases of white blood cell number and function. Dr. Newburger’s laboratory uses human and mouse genetics to understand white blood cell production and function, how this goes awry in disease, and how to correct genetic disorders by gene therapy.
Publications
European guidelines on treatment and supportive measures in chronic neutropenias: A consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence review. View Abstract
Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome. View Abstract
High symptom burden in female X-linked chronic granulomatous disease carriers. View Abstract
Absence of Neutropenia in Patients With Early Exon Nonsense Mutations in ELANE : Clinical Evidence to Support Gene Therapy Approaches for Severe Congenital Neutropenia. View Abstract
Clinical Remission of Severe Crohn's Disease with Empagliflozin Monotherapy in a Pediatric Patient with Glycogen Storage Disease Type 1b. View Abstract
The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action. View Abstract
Reply to: Stand with Ukraine. View Abstract
Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor. View Abstract
Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease. View Abstract
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing. View Abstract
Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency. View Abstract
Lentiviral gene therapy for X-linked chronic granulomatous disease. View Abstract
Gene Editing ELANE in Human Hematopoietic Stem and Progenitor Cells Reveals Disease Mechanisms and Therapeutic Strategies for Severe Congenital Neutropenia. View Abstract
Benign ethnic neutropenia. View Abstract
Aberrant splicing contributes to severe a-spectrin-linked congenital hemolytic anemia. View Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. View Abstract
Neutropenia in the age of genetic testing: Advances and challenges. View Abstract
Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro. View Abstract
The Genetic Landscape of Diamond-Blackfan Anemia. View Abstract
How we approach: Severe congenital neutropenia and myelofibrosis due to mutations in VPS45. View Abstract
Gene expression in chronic granulomatous disease and interferon-? receptor-deficient cells treated in vitro with interferon-?. View Abstract
Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. View Abstract
Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. View Abstract
"How I approach…"-A new series in Pediatric Blood & Cancer. View Abstract
Comment on: Phenotypic Prenatal Diagnosis of Chronic Granulomatous Disease: A Useful Tool in the Absence of Molecular Diagnosis. View Abstract
Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia. View Abstract
A novel homozygous VPS45 p.P468L mutation leading to severe congenital neutropenia with myelofibrosis. View Abstract
Laurence A. Boxer, MD, 1940-2017. View Abstract
Autoimmune and other acquired neutropenias. View Abstract
An oral HemokineTM, a-methylhydrocinnamate, enhances myeloid and neutrophil recovery following irradiation in vivo. View Abstract
Mild Microcytic Anemia in an Infant with a Compound Heterozygosity for Hb C (HBB: c.19G?>?A) and Hb Osu Christiansborg (HBB: c.157G?>?A). View Abstract
Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation. View Abstract
Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9. View Abstract
Neutrophil Responses to Sterile Implant Materials. View Abstract
Regulation of CYBB Gene Expression in Human Phagocytes by a Distant Upstream NF-?B Binding Site. View Abstract
In memoriam: Robert J. Arceci. View Abstract
Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia. View Abstract
The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. View Abstract
Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patients with inherited IFN-?R1 or IFN-?R2 deficiency. View Abstract
Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. View Abstract
HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all trans retinoic acid treated NB4 promyelocytic leukemia cells. View Abstract
Evaluation and management of patients with isolated neutropenia. View Abstract
Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. View Abstract
Advances in understanding the pathogenesis of HLH. View Abstract
Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. View Abstract
The human NADPH oxidase: primary and secondary defects impairing the respiratory burst function and the microbicidal ability of phagocytes. View Abstract
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. View Abstract
Hemophagocytic lymphohistiocytosis with MUNC13-4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia. View Abstract
Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes. View Abstract
Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. View Abstract
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy. View Abstract
X chromosome-wide analyses of genomic DNA methylation states and gene expression in male and female neutrophils. View Abstract
Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. View Abstract
Comment on "Impaired priming and activation of the neutrophil NADPH oxidase in patients with IRAK4 or NEMO deficiency". View Abstract
Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture. View Abstract
Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS). View Abstract
Cyclic neutropenia in animals. View Abstract
A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. View Abstract
Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. View Abstract
Toll-like receptor-mediated activation of neutrophils by influenza A virus. View Abstract
Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes. View Abstract
The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD. View Abstract
IL6 to the rescue. View Abstract
Mosaic tetraploidy and transient GFI1 mutation in a patient with severe chronic neutropenia. View Abstract
Up-regulation of NADPH oxidase components and increased production of interferon-gamma by leukocytes from sickle cell disease patients. View Abstract
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. View Abstract
A molecular classification of congenital neutropenia syndromes. View Abstract
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. View Abstract
Temporal evolution of gene expression in rat carotid artery following balloon angioplasty. View Abstract
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. View Abstract
A limited number of genes are involved in the differentiation of germinal center B cells. View Abstract
Nuclease sensitive element binding protein 1 gene disruption results in early embryonic lethality. View Abstract
Nuclease sensitive element binding protein 1 associates with the selenocysteine insertion sequence and functions in mammalian selenoprotein translation. View Abstract
Acute lymphocytic leukemia with eosinophilia and unusual karyotype. View Abstract
Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular genetics. View Abstract
Novel transcribed regions in the human genome. View Abstract
Disorders of neutrophil number and function. View Abstract
The effect of IFN-gamma and TNF-alpha on the NADPH oxidase system of human colostrum macrophages, blood monocytes, and THP-1 cells. View Abstract
Hematology and oncology. View Abstract
The role of toll-like receptors in herpes simplex infection in neonates. View Abstract
A panorama of lineage-specific transcription in hematopoiesis. View Abstract
Superoxide release and cellular gluthatione peroxidase activity in leukocytes from children with persistent asthma. View Abstract
p47(phox) PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeleton. View Abstract
Lineage specificity of gene expression patterns. View Abstract
Association of glucose-6-phosphate dehydrogenase deficiency and X-linked chronic granulomatous disease in a child with anemia and recurrent infections. View Abstract
Hematology and oncology. View Abstract
The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells. View Abstract
Gene expression in mature neutrophils: early responses to inflammatory stimuli. View Abstract
BARCODE-ALL: accelerated and cost-effective genetic risk stratification in acute leukemia using spectrally addressable liquid bead microarrays. View Abstract
BARCODE-ALL: accelerated and cost-effective genetic risk stratification in acute leukemia using spectrally addressable liquid bead microarrays. View Abstract
Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharide. View Abstract
Hematology and oncology. View Abstract
Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line. View Abstract
Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. View Abstract
Adolescents with cancer: access to clinical trials and age-appropriate care. View Abstract
An unusual intronic mutation in the CYBB gene giving rise to chronic granulomatous disease. View Abstract
Genomic and proteomic analysis of the myeloid differentiation program. View Abstract
RNA expression patterns change dramatically in human neutrophils exposed to bacteria. View Abstract
Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in the NCF-1 pseudogenes. View Abstract
Interferon-gamma improves splicing efficiency of CYBB gene transcripts in an interferon-responsive variant of chronic granulomatous disease due to a splice site consensus region mutation. View Abstract
Recognition and binding of the human selenocysteine insertion sequence by nucleolin. View Abstract
Global analysis of neutrophil gene expression. View Abstract
Hematology and oncology. View Abstract
A modified method for the display of 3'-end restriction fragments of cDNAs: molecular profiling of gene expression in neutrophils. View Abstract
NADPH oxidase activity and cytochrome b558 content of human Epstein-Barr-virus-transformed B lymphocytes correlate with expression of genes encoding components of the oxidase system. View Abstract
Differential expression of Id genes in multipotent myeloid progenitor cells: Id-1 is induced by early-and late-acting cytokines while Id-2 is selectively induced by cytokines that drive terminal granulocytic differentiation. View Abstract
Dexamethasone but not indomethacin inhibits human phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity by down-regulating expression of genes encoding oxidase components. View Abstract
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. View Abstract
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304. View Abstract
Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. View Abstract
Hematology and oncology. View Abstract
Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. View Abstract
Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. View Abstract
Expression of basic helix-loop-helix transcription factors in explant hematopoietic progenitors. View Abstract
Partial reconstitution of the respiratory burst oxidase in lymphoblastoid B cell lines lacking p67-phox after transfection with an expression vector containing wild-type and mutant p67 -phox cDNAs: Deletions of the carboxy and amino terminal residues of p67-phox are not required for activity. View Abstract
Umbilical cord blood as a new and promising source of unrelated-donor hematopoietic stem cells for transplantation. View Abstract
RNA-binding proteins that specifically recognize the selenocysteine insertion sequence of human cellular glutathione peroxidase mRNA. View Abstract
Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. View Abstract
A new X-linked variant of chronic granulomatous disease characterized by the existence of a normal clone of respiratory burst-competent phagocytic cells. View Abstract
Chronic granulomatous disease and glutathione peroxidase deficiency, revisited. View Abstract
Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation. View Abstract
An in-frame trinucleotide repeat in the coding region of the human cellular glutathione peroxidase (GPX1) gene: in vivo polymorphism and in vitro instability. View Abstract
Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558. View Abstract
Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA. View Abstract
Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B. View Abstract
Chemotactic peptide-induced cytoplasmic pH changes in incubated human monocytes. View Abstract
Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon. View Abstract
Human immunodeficiency virus type 1-infected HL-60 cells are capable of both monocytic and granulocytic differentiation. View Abstract
O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA. View Abstract
Chronic granulomatous disease presenting in a 69-year-old man. View Abstract
In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines. View Abstract
Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. View Abstract
Measurement of superoxide release in the phagovacuoles of immune complex-stimulated human neutrophils. View Abstract
Simultaneous flow cytometric measurements of cytoplasmic Ca++ and membrane potential changes upon FMLP exposure as HL-60 cells mature into granulocytes: using [Ca++]in as an indicator of granulocyte maturity. View Abstract
Isolation and chromosomal localization of the human glutathione peroxidase gene. View Abstract
Relationships between the cell cycle and the expression of c-myc and transferrin receptor genes during induced myeloid differentiation. View Abstract
Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line. View Abstract
Differentiation of human hematopoietic cells increases expression of a gene transferred by a retroviral vector. View Abstract
Infection of hematopoietic and stromal cells in human continuous bone marrow cultures by a retroviral vector containing the neomycin resistance gene. View Abstract
New perspectives in chronic granulomatous disease. View Abstract
Partial correction of the phagocyte defect in patients with X-linked chronic granulomatous disease by subcutaneous interferon gamma. View Abstract
Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. View Abstract
Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. View Abstract
Cellular and molecular effects of recombinant interferon gamma in chronic granulomatous disease. View Abstract
Marrow donors and international cooperation. View Abstract
Recombinant interferon gamma augments phagocyte superoxide production and X-chronic granulomatous disease gene expression in X-linked variant chronic granulomatous disease. View Abstract
Biochemical and morphological characterization of basophilic leukocytes from two patients with myelogenous leukemia. View Abstract
Changes in superoxide dismutase, catalase, and the glutathione cycle during induced myeloid differentiation. View Abstract
Neutrophil defect associated with malignant infantile osteopetrosis. View Abstract
Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. View Abstract
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. View Abstract
Characterization of a spontaneous mutation to a beta-thalassemia allele. View Abstract
Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity. View Abstract
Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. View Abstract
Long-term culture of human granulocytes and granulocyte progenitor cells. View Abstract
Pseudomonas cepacia pneumonia in chronic granulomatous disease. View Abstract
Relationships between in vitro selenium supply, glutathione peroxidase activity, and phagocytic function in the HL-60 human myeloid cell line. View Abstract
Modulation of mononuclear phagocyte cytotoxicity by alpha-tocopherol (vitamin E). View Abstract
Chediak-Higashi syndrome: studies in long-term bone marrow culture. View Abstract
Development of the superoxide-generating system during differentiation of the HL-60 human promyelocytic leukemia cell line. View Abstract
Studies on low-dose hydroxyethyl starch leukapheresis. Rate of elimination of HES in vivo and function of the harvested granulocytes in vitro. View Abstract
Impaired granulocyte superoxide production and prolongation of the respiratory burst due to a low-affinity NADPH-dependent oxidase. View Abstract
Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst. View Abstract
Eosinophilic cytoplasmic inclusions in fetal leukocytes: are Auer bodies a recapitulation of fetal morphology? View Abstract
Chronic granulomatous disease due to granulocytes with abnormal NADPH oxidase activity and deficient cytochrome-b. View Abstract
Allogeneic bone marrow transplantation for chronic granulomatous disease. View Abstract
Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase. View Abstract
Heterogeneous pathways of oxidizing radical production in human neutrophils and the HL-60 cell line. View Abstract
Superoxide generation by human fetal granulocytes. View Abstract
Opsonized zymosan-stimulated granulocytes-activation and activity of the superoxide-generating system and membrane potential changes. View Abstract
Human granulocytes generated in continuous bone marrow culture are physiologically normal. View Abstract
The effects of irradiation on blood components. View Abstract
Functionally deficient differentiation of HL-60 promyelocytic leukemia cells induced by phorbol myristate acetate. View Abstract
Leukemia relapse in donor cells after allogeneic bone-marrow transplantation. View Abstract
Chronic pain: principles of management. View Abstract
Corticosteroid dependence of continuous hemopoiesis in vitro with murine or human bone marrow. View Abstract
Chronic granulomatous disease. Expression of the metabolic defect by in vitro culture of bone marrow progenitors. View Abstract
Phorbol myristate acetate stimulates macrophage differentiation and replication and alters granulopoiesis and leukemogenesis in long-term bone marrow cultures. View Abstract
NAD(P)H-dependent superoxide production by phagocytic vesicles from guinea pig and human granulocytes. View Abstract
Dissociation of opsonized particle phagocytosis and respiratory burst activity in an Epstein-Barr virus-infected myeloid cell line. View Abstract
Correction of infantile agranulocytosis (Kostmann's syndrome) by allogeneic bone marrow transplantation. View Abstract
Virus and cell requirements for Friend virus granulocytic leukemogenesis in long-term bone marrow cultures of NIH swiss [N:NIH(S)] mice. View Abstract
Activity and activation of the granulocyte superoxide-generating system. View Abstract
Functional changes in human leukemic cell line HL-60. A model for myeloid differentiation. View Abstract
Improved fluorescent staining of interphase nuclei for prenatal diagnosis. View Abstract
Esophagitis induced by combined radiation and adriamycin. View Abstract
Prenatal diagnosis of chronic granulomatous disease. View Abstract
Constitutive and inducible granulocyte-macrophage functions in mouse, rat, and human myeloid leukemia-derived continuous tissue culture lines. View Abstract
Esophagitis due to adriamycin and radiation therapy for childhood malignancy. View Abstract
Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells. View Abstract
Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes. View Abstract
Potentiation of helper T cell function in IgE antibody responses by bacterial lipolysaccharide (LPS). View Abstract
Characterization of an immune response gene in mice controlling IgE and IgM antibody responses to ragweed pollen extract and its 2,4-dinitrophenylated derivative. View Abstract