Raif S. Geha, MD
James L. Gamble Professor of Pediatrics, Harvard Medical School
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Raif S. Geha, MD
James L. Gamble Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
Arabic
English
Education
Medical School
American University of Beirut
1969
Beirut
Lebanon
Internship
American University of Beirut
1969
Beirut
Lebanon
Residency
Boston Children's Hospital
1971
Boston Children's Hospital
MA
Fellowship
Boston Children's Hospital
1974
Boston
MA
Certifications
American Board of Allergy & Immunology (General)
American Board of Allergy & Immunology (Diagnostic Laboratory Immunology)
American Board of Pediatrics (General)
Publications
Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature. View Abstract
Germline mutations in a G protein identify signaling cross-talk in T cells. View Abstract
IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation. View Abstract
Reflections on a half century of mentoring. View Abstract
Phosphodiesterase 4 Inhibitors, Basophils, and Atopic Dermatitis. View Abstract
Clinical, immunological features, treatments, and outcomes of autoimmune hemolytic anemia in patients with RAG deficiency. View Abstract
Basophils are important for development of allergic skin inflammation. View Abstract
Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice. View Abstract
Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency. View Abstract
Ant Venom-Based Ceramide Therapy Is Effective Against Atopic Dermatitis In Vivo. View Abstract
DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection. View Abstract
IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin. View Abstract
The IL-4Ra Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. View Abstract
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. View Abstract
NFKB2 haploinsufficiency identified via screening for IFN-a2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2-related complications. View Abstract
Immune dysregulation caused by homozygous mutations in CBLB. View Abstract
The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity. View Abstract
A homozygous truncating mutation of FGL2 is associated with immune dysregulation. View Abstract
Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry. View Abstract
Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. View Abstract
Inborn Errors of the Immune System Associated With Atopy. View Abstract
Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection. View Abstract
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children. View Abstract
Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions. View Abstract
Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. View Abstract
Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors. View Abstract
Combined immunodeficiency with autoimmunity caused by a homozygous missense mutation in inhibitor of nuclear factor ??B kinase alpha (IKKa). View Abstract
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. View Abstract
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). View Abstract
Basophil: The cell that itches. View Abstract
Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. View Abstract
Macabre TH2 skewing in DOCK8 deficiency. View Abstract
Multi-kingdom ecological drivers of microbiota assembly in preterm infants. View Abstract
Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. View Abstract
Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure. View Abstract
Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient with EBV-induced lymphoproliferation. View Abstract
DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity. View Abstract
Transferrin receptor 1 is a cellular receptor for human heme-albumin. View Abstract
Hematopoietic Stem Cell Transplantation Is a Curative Therapy for Transferrin Receptor 1 (TFRC) Deficiency. View Abstract
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. View Abstract
Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. View Abstract
APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice. View Abstract
DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. View Abstract
Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing. View Abstract
ITK deficiency presenting as autoimmune lymphoproliferative syndrome. View Abstract
Inherited human IFN-? deficiency underlies mycobacterial disease. View Abstract
Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! View Abstract
Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome. View Abstract
ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. View Abstract
Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. View Abstract
Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). View Abstract
Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation. View Abstract
Dysregulated actin dynamics in activated PI3Kd syndrome. View Abstract
A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation. View Abstract
Combined immunodeficiency in a patient with c-Rel deficiency. View Abstract
A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis. View Abstract
Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. View Abstract
Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. View Abstract
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. View Abstract
Rethinking newborn screening for severe combined immunodeficiency: Lessons from an international partnership for patients with primary immunodeficiencies in Pakistan. View Abstract
T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients. View Abstract
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. View Abstract
Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population. View Abstract
A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency. View Abstract
Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". View Abstract
Primary immunodeficiencies caused by mutations in actin regulatory proteins. View Abstract
Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. View Abstract
Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-?B-inducing kinase deficiency. View Abstract
Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency. View Abstract
Human primary immunodeficiency caused by expression of a kinase-dead p110d mutant. View Abstract
Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release. View Abstract
Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. View Abstract
Defective TLR9-driven STAT3 activation in B cells of patients with CVID. View Abstract
MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice. View Abstract
Autosomal Recessive Agammaglobulinemia - first case with a novel TCF3 mutation from Pakistan. View Abstract
The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. View Abstract
IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice. View Abstract
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. View Abstract
RORa-expressing T regulatory cells restrain allergic skin inflammation. View Abstract
Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay. View Abstract
Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses. View Abstract
A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. View Abstract
DOCK8 Deficiency Presenting as an IPEX-Like Disorder. View Abstract
DNA recombination defects in Kuwait: Clinical, immunologic and genetic profile. View Abstract
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. View Abstract
A novel mutation in the JH4 domain of JAK3 causing severe combined immunodeficiency complicated by vertebral osteomyelitis. View Abstract
Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. View Abstract
DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. View Abstract
Advances in basic and clinical immunology in 2016. View Abstract
Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. View Abstract
Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies. View Abstract
Cernunnos deficiency associated with BCG adenitis and autoimmunity: First case from the national Iranian registry and review of the literature. View Abstract
Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. View Abstract
Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. View Abstract
Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. View Abstract
The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils. View Abstract
Disseminated Mycobacterium malmoense and Salmonella Infections Associated with a Novel Variant in NFKBIA. View Abstract
Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. View Abstract
Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site. View Abstract
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. View Abstract
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. View Abstract
Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. View Abstract
Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult. View Abstract
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. View Abstract
Mutations in pyrin masquerading as a primary immunodeficiency. View Abstract
IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin. View Abstract
Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. View Abstract
Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. View Abstract
IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. View Abstract
Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. View Abstract
Hyper IgM Syndrome: a Report from the USIDNET Registry. View Abstract
Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C-terminus that interacts with STIM 1. View Abstract
Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. View Abstract
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. View Abstract
O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. View Abstract
Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. View Abstract
Spectrum of Phenotypes Associated with Mutations in LRBA. View Abstract
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. View Abstract
Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. View Abstract
Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly. View Abstract
Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. View Abstract
Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. View Abstract
Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. View Abstract
A novel mutation in NCF2 associated with autoimmune disease and a solitary late-onset infection. View Abstract
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. View Abstract
A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function. View Abstract
The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells. View Abstract
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. View Abstract
A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. View Abstract
Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. View Abstract
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in I?Ba. View Abstract
The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice. View Abstract
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. View Abstract
Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. View Abstract
Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. View Abstract
A novel mutation in FOXN1 resulting in SCID: a case report and literature review. View Abstract
The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency. View Abstract
CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. View Abstract
Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells. View Abstract
A novel disease-causing CD40L mutation reduces expression of CD40 ligand, but preserves CD40 binding capacity. View Abstract
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. View Abstract
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. View Abstract
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. View Abstract
Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. View Abstract
Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. View Abstract
TRIF signaling is essential for TLR4-driven IgE class switching. View Abstract
Food allergy: Insights into etiology, prevention, and treatment provided by murine models. View Abstract
Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. View Abstract
A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. View Abstract
Gene hunting in the genomic era: approaches to diagnostic dilemmas in patients with primary immunodeficiencies. View Abstract
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. View Abstract
T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation. View Abstract
C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. View Abstract
A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. View Abstract
Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. View Abstract
Wiskott-Aldrich syndrome: a comprehensive review. View Abstract
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. View Abstract
Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. View Abstract
Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death. View Abstract
Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia. View Abstract
Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies. View Abstract
Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. View Abstract
Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. View Abstract
SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils. View Abstract
A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome. View Abstract
LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency. View Abstract
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. View Abstract
Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. View Abstract
Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. View Abstract
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. View Abstract
A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. View Abstract
Vaccinia Ig ameliorates eczema vaccinatum in a murine model of atopic dermatitis. View Abstract
Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. View Abstract
Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis. View Abstract
Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. View Abstract
Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. View Abstract
Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. View Abstract
A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding. View Abstract
Ligation of CD46 to CD40 inhibits CD40 signaling in B cells. View Abstract
Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. View Abstract
The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. View Abstract
Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. View Abstract
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. View Abstract
Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. View Abstract
The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. View Abstract
Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. View Abstract
Parental consanguinity and the risk of primary immunodeficiency disorders: report from the Kuwait National Primary Immunodeficiency Disorders Registry. View Abstract
Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. View Abstract
Thymic stromal lymphopoietin. View Abstract
Primary immunodeficiencies: 2009 update. View Abstract
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. View Abstract
Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. View Abstract
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. View Abstract
Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. View Abstract
The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. View Abstract
Reply to Narra. View Abstract
Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. View Abstract
Common variable immunodeficiency. View Abstract
WIP is critical for T cell responsiveness to IL-2. View Abstract
Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. View Abstract
TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. View Abstract
Cellular and molecular mechanisms in atopic dermatitis. View Abstract
Recent advances in the biology of WASP and WIP. View Abstract
Animal models of atopic dermatitis. View Abstract
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. View Abstract
Primary immune deficiencies with aberrant IgE production. View Abstract
Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. View Abstract
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. View Abstract
A girl with severe hand swelling and abdominal cramps. View Abstract
TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. View Abstract
Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. View Abstract
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. View Abstract
Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. View Abstract
Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. View Abstract
Images in immunodeficiency. View Abstract
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. View Abstract
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. View Abstract
Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. View Abstract
Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. View Abstract
Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. View Abstract
Transcellular diapedesis is initiated by invasive podosomes. View Abstract
Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). View Abstract
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). View Abstract
TACI, isotype switching, CVID and IgAD. View Abstract
A novel anti-WIP monoclonal antibody detects an isoform of WIP that lacks the WASP binding domain. View Abstract
Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. View Abstract
CD1d restricted natural killer T cells are not required for allergic skin inflammation. View Abstract
TACI mutation in common variable immunodeficiency and IgA deficiency. View Abstract
3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. View Abstract
IPEX and the role of Foxp3 in the development and function of human Tregs. View Abstract
The H1 histamine receptor regulates allergic lung responses. View Abstract
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. View Abstract
A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. View Abstract
Molecular basis of common variable immunodeficiency. View Abstract
The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. View Abstract
2. Update on primary immunodeficiency diseases. View Abstract
Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. View Abstract
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. View Abstract
Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. View Abstract
Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's Hospital. View Abstract
WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. View Abstract
COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. View Abstract
Are you immunodeficient? View Abstract
TACI is mutant in common variable immunodeficiency and IgA deficiency. View Abstract
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. View Abstract
Role of APRIL in the mucosal Iga antibody response. View Abstract
Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. View Abstract
Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. View Abstract
TACI and BAFF-R mediate isotype switching in B cells. View Abstract
Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. View Abstract
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. View Abstract
Primary immunodeficiency diseases: an update. View Abstract
The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. View Abstract
RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. View Abstract
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. View Abstract
The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. View Abstract
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. View Abstract
Impaired IgA class switching in APRIL-deficient mice. View Abstract
WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. View Abstract
Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. View Abstract
Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. View Abstract
The mature activating natural killer cell immunologic synapse is formed in distinct stages. View Abstract
The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. View Abstract
Epicutaneous sensitization with superantigen induces allergic skin inflammation. View Abstract
Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. View Abstract
Finding NEMO: genetic disorders of NF-[kappa]B activation. View Abstract
IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. View Abstract
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. View Abstract
The regulation of immunoglobulin E class-switch recombination. View Abstract
Acute chylothorax in children: selective retention of memory T cells and natural killer cells. View Abstract
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. View Abstract
Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. View Abstract
C4b-binding protein (C4BP) activates B cells through the CD40 receptor. View Abstract
WIP participates in actin reorganization and ruffle formation induced by PDGF. View Abstract
Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. View Abstract
Primary immunodeficiency diseases: an update. View Abstract
IgG Fc receptor polymorphisms in human disease: implications for intravenous immunoglobulin therapy. View Abstract
12. Primary immunodeficiency diseases. View Abstract
Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. View Abstract
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. View Abstract
X-linked lymphoproliferative disease: genetic lesions and clinical consequences. View Abstract
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. View Abstract
Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. View Abstract
Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. View Abstract
Aspartame: review of safety. View Abstract
CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. View Abstract
WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. View Abstract
Differential role of SLP-76 domains in T cell development and function. View Abstract
Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. View Abstract
IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils. View Abstract
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. View Abstract
TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. View Abstract
WIP regulates N-WASP-mediated actin polymerization and filopodium formation. View Abstract
Desloratadine: A new, nonsedating, oral antihistamine. View Abstract
IgE regulation and roles in asthma pathogenesis. View Abstract
Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. View Abstract
An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. View Abstract
Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. View Abstract
Allergy, a disease of the internal and external environments View Abstract
CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. View Abstract
Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. View Abstract
Identification and characterization of two CD40-inducible enhancers in the mouse TRAF1 gene locus. View Abstract
The role of SLP-76 and LAT in lymphocyte development. View Abstract
Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. View Abstract
Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III. View Abstract
Molecular mechanisms of IgE regulation. View Abstract
Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. View Abstract
IgE in asthma and atopy: cellular and molecular connections. View Abstract
Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. View Abstract
The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. View Abstract
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. View Abstract
Structure of the murine TRAF1 gene. View Abstract
Contribution of CD40-CD154-mediated costimulation to an alloresponse in vivo. View Abstract
Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: a double-blind, placebo-controlled, randomized trial. View Abstract
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. View Abstract
Regulation of IgE synthesis: the molecular basis and implications for clinical modulation. View Abstract
Waltzing with WASP. View Abstract
The mouse genome contains two expressed intronless retroposed pseudogenes for the sentrin/sumo-1/PIC1 conjugating enzyme Ubc9. View Abstract
Role of JAK3 in CD40-mediated signaling. View Abstract
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. View Abstract
The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. View Abstract
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. View Abstract
IgE-mediated allergy and desensitization to factor IX in hemophilia B. View Abstract
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. View Abstract
Molecular mechanisms of immunoglobulin E regulation. View Abstract
CD40 ligation and IL-4 use different mechanisms of transcriptional activation of the human lymphotoxin alpha promoter in B cells. View Abstract
The hyper-IgM (HIM) syndrome. View Abstract
WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. View Abstract
Targeted gene disruption of murine CD7. View Abstract
Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. View Abstract
Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. View Abstract
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. View Abstract
Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. View Abstract
Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. View Abstract
CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2. View Abstract
HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. View Abstract
Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP). View Abstract
Large-volume leukapheresis in pediatric patients: processing more blood diminishes the apparent magnitude of intra-apheresis recruitment. View Abstract
The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. View Abstract
Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. View Abstract
Mechanisms of inhibition of IgE synthesis by nedocromil sodium: nedocromil sodium inhibits deletional switch recombination in human B cells. View Abstract
CD40 expression and function in murine B cell ontogeny. View Abstract
Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). View Abstract
The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. View Abstract
Characterization of a 23-kDa protein associated with CD40. View Abstract
Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes. View Abstract
Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID). View Abstract
CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). View Abstract
CD40-mediated lymphotoxin alpha expression in human B cells is tyrosine kinase dependent. View Abstract
Bacterial superantigens induce the proliferation of resting gamma/delta receptor bearing T cells. View Abstract
Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. View Abstract
CD40 ligand expression is developmentally regulated in human thymocytes. View Abstract
Association of the high-affinity receptor for IgG with the protein tyrosine kinases Hck and Lyn. View Abstract
Activation of tumor necrosis factor-alpha and lymphotoxin-alpha via anti-CD40 in human B cells. View Abstract
CD40 ligand/CD40 deficiency. View Abstract
Expression of the CD40 ligand in T lymphocytes and induction of IgE isotype switching. View Abstract
A point mutation in exon 2 of the CD40 ligand gene causes the simultaneous expression of two defective mRNA species in X-linked hyperimmunoglobulinemia M. View Abstract
Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4. View Abstract
gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. View Abstract
Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells. View Abstract
X-linked agammaglobulinemia and immunoglobulin deficiency with normal or elevated IgM: immunodeficiencies of B cell development and differentiation. View Abstract
CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. View Abstract
CD40 ligation induces lymphotoxin alpha gene expression in human B cells. View Abstract
Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells. View Abstract
A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen. View Abstract
Immunosuppressant deoxyspergualin inhibits antigen processing in monocytes. View Abstract
Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. View Abstract
MHC class II signaling in B-cell activation. View Abstract
Superantigens activate HIV-1 gene expression in monocytic cells. View Abstract
Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. View Abstract
Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells. View Abstract
Decreased expression of the ligand for CD40 in newborn lymphocytes. View Abstract
Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells. View Abstract
Structure of the murine CD40 ligand gene. View Abstract
Molecular pathology of X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). View Abstract
Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. View Abstract
Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. View Abstract
Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. View Abstract
Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. View Abstract
Role of CD40-CD40-ligand interaction in Ig-isotype switching. View Abstract
Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone. View Abstract
Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma). View Abstract
Aspartame is no more likely than placebo to cause urticaria/angioedema: results of a multicenter, randomized, double-blind, placebo-controlled, crossover study. View Abstract
Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells. View Abstract
Therapy for patients with recurrent infections and low serum IgG3 levels. View Abstract
Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). View Abstract
Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1. View Abstract
Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency. View Abstract
Chromosomal localization of the gene for human B-cell antigen CD40. View Abstract
A protein of the AP-1 family is a component of nuclear factor of activated T cells. View Abstract
Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. View Abstract
Signal transduction by microbial superantigens via MHC class II molecules. View Abstract
Severe combined immunodeficiency with selective T-cell cytokine genes. View Abstract
Regulation of IgE synthesis: from the membrane to the genes. View Abstract
Localization of the genetic defect in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1) to the CD40 ligand gene. View Abstract
Regulation of isotype switching. View Abstract
IgE regulation and lymphokine patterns in aging humans. View Abstract
Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands. View Abstract
Protein tyrosine phosphorylation induced via the IgG receptors Fc gamma Ri and Fc gamma RII in the human monocytic cell line THP-1. View Abstract
Regulation of IgE synthesis in humans. View Abstract
Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells. View Abstract
Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways. View Abstract
Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. View Abstract
Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes. View Abstract
A toxic shock syndrome toxin-1 peptide that shows homology to mycobacterial heat shock protein 18 is presented as conventional antigen to T cells by multiple HLA-DR alleles. View Abstract
Superantigens. View Abstract
Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. View Abstract
Molecular analysis of the induction of immunoglobulin E synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. View Abstract
Lymphokine profile in bone marrow transplant recipients. View Abstract
Cardiotoxicity during treatment of severe childhood asthma. View Abstract
Novel immune deficiencies: defective transcription of lymphokine genes. View Abstract
Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells. View Abstract
Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. View Abstract
Regulation of IgE synthesis in humans: a tale of two signals. View Abstract
Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. View Abstract
Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells. View Abstract
Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands. View Abstract
Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells. View Abstract
Toxic shock syndrome toxin-1, toxic shock, and the immune system. View Abstract
Induction of human T cell proliferation by a monoclonal antibody to CD5. View Abstract
Novel immune deficiencies: defective transcription of lymphokine genes. View Abstract
CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. View Abstract
Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. View Abstract
Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV. View Abstract
Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion. View Abstract
Interleukin 4 down-regulates the expression of CD14 in normal human monocytes. View Abstract
Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion. View Abstract
Binding of toxic shock syndrome toxin-1 to murine major histocompatibility complex class II molecules. View Abstract
Response to a Haemophilus influenzae type b diphtheria CRM197 conjugate vaccine in children with a defect of antibody production to Haemophilus influenzae type b polysaccharide. View Abstract
Bone marrow transplantation (BMT) for the syndrome of pigmentary dilution and lymphohistiocytosis (Griscelli's syndrome). View Abstract
Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. View Abstract
Recombinant gamma interferon in treatment of patients with atopic dermatitis and elevated IgE levels. View Abstract
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. View Abstract
IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures. View Abstract
Effect of isotypes and allelic polymorphism on the binding of staphylococcal exotoxins to MHC class II molecules. View Abstract
T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. View Abstract
Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. View Abstract
The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. View Abstract
Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules. View Abstract
Mechanisms of T cell activation by the calcium ionophore ionomycin. View Abstract
Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. View Abstract
The evolution of MHC restrictions in antigen recognition by T cells in a haploidentical bone marrow transplant recipient. View Abstract
The IgE system. View Abstract
Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. View Abstract
Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. View Abstract
The B-cell binding site on human immunoglobulin E. View Abstract
Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. View Abstract
An immunodeficiency characterized by defective signal transduction in T lymphocytes. View Abstract
Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. View Abstract
Regulation of IgE synthesis in humans. View Abstract
Intracellular cleavage of newly synthesized low affinity Fc epsilon receptor (Fc epsilon R2) provides a second pathway for the generation of the 28-kDa soluble Fc epsilon R2 fragment. View Abstract
Interleukin 4 dependent induction of IgE synthesis and CD23 expression by the supernatants of a human helper T cell clone. View Abstract
Hyper immunoglobulin E syndrome. View Abstract
Regulation of human IgE synthesis. View Abstract
IgE response and its regulation in allergic diseases. View Abstract
Phosphorylation of T cell membrane proteins by activators of protein kinase C. View Abstract
Impaired antibody responses in the hyperimmunoglobulin E syndrome. View Abstract
Antibody deficiency syndromes and novel immunodeficiencies. View Abstract
Recognition by a human alloreactive T-cell clone of an HLA-DP-associated epitope on monocytes and fibroblasts but not on B cells. View Abstract
Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes. View Abstract
Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome. View Abstract
Regulation of IgE synthesis in atopic disease. View Abstract
Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. View Abstract
Asthma, recurrent infections and IgG2 deficiency. View Abstract
Fatal varicella in steroid-dependent asthma. View Abstract
IgG antibody response to polysaccharides in children with recurrent infections. View Abstract
Increased in vitro bone resorption by monocytes in the hyper-immunoglobulin E syndrome. View Abstract
Cell cooperation in haploidentical bone marrow transplant recipient. View Abstract
Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. View Abstract
The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis. View Abstract
Regulation of the human IgE antibody response. View Abstract
Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. View Abstract
Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease. View Abstract
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. View Abstract
Analysis of antigen uptake and presentation by Epstein-Barr virus-transformed human lymphoblastoid B cells. View Abstract
Mechanisms of the failure of resting B cells to present tetanus toxoid antigen to T cells. View Abstract
Immunoregulatory T-cell defects. View Abstract
Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. View Abstract
Macrophage T-cell interaction in man: handling of tetanus toxoid antigen by human monocytes. View Abstract
Hyper immunoglobulin M immunodeficiency. (Dysgammaglobulinemia). Presence of immunoglobulin M-secreting plasmacytoid cells in peripheral blood and failure of immunoglobulin M-immunoglobulin G switch in B-cell differentiation. View Abstract
The specificity of T-cell helper factor in man. View Abstract
Cooperation between human thymus-derived and bone marrow-derived lymphocytes in the antibody response to ragweed antigen E in vitro. View Abstract
Heterogeneity of "acquired" or common variable agammaglobulinemia. View Abstract
Synthesis of an M component by circulating B lymphocytes in severe combined immunodeficiency. View Abstract
Interaction of human thymus-derived and non-thymus-derived lymphocytes in vitro. Induction of proliferation and antibody synthesis in B lymphocytes by a soluble factor released from antigen-stimulated T lymphocytes. View Abstract
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