Richard Malley, MD
Senior Physician in Pediatrics, Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
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Richard Malley, MD
Senior Physician in Pediatrics, Division of Infectious Diseases
Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
Tufts University School of Medicine
1990
Boston
MA
Internship
Pediatrics
Boston Children's Hospital
1991
Boston
MA
Residency
Boston Children's Hospital
1993
Boston
MA
Fellowship
Pediatric Infectious Diseases; Pediatric Emergency Medicine
Boston Children's Hospital
1996
Boston
MA
Certifications
American Board of Pediatrics (Infectious Diseases)
Publications
Safety, reactogenicity, and immunogenicity of a novel 24-valent pneumococcal vaccine candidate in healthy, pneumococcal vaccine-naïve Japanese adults: A phase 1 randomized dose-escalation trial. View Abstract
Surface protein distribution in Group B Streptococcus isolates from South Africa and identifying vaccine targets through in silico analysis. View Abstract
Evaluation of a Quadrivalent Shigella flexneri Serotype 2a, 3a, 6, and Shigella sonnei O-Specific Polysaccharide and IpaB MAPS Vaccine. View Abstract
CC180 clade dynamics do not universally explain Streptococcus pneumoniae serotype 3 persistence post-vaccine: a global comparative population genomics study. View Abstract
Corrigendum to "Phase 1/2 study of a novel 24-valent pneumococcal vaccine in healthy adults aged 18 to 64 years and in older adults aged 65 to 85 years" [Vaccine 40 (2022) 4190-4198]. View Abstract
Household Transmission Dynamics of Asymptomatic SARS-CoV-2-Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study. View Abstract
Vaccination for healthy aging. View Abstract
Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2. View Abstract
Safety, tolerability and immunogenicity of a novel 24-valent pneumococcal vaccine in toddlers: A phase 1 randomized controlled trial. View Abstract
Immunization with a whole cell vaccine reduces pneumococcal nasopharyngeal density and shedding, and middle ear infection in mice. View Abstract
Multiple antigen presenting system (MAPS): state of the art and potential applications. View Abstract
Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A. View Abstract
Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children. View Abstract
A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis. View Abstract
A Bivalent MAPS Vaccine Induces Protective Antibody Responses against Salmonella Typhi and Paratyphi A. View Abstract
Acute otitis media pneumococcal disease burden and nasopharyngeal colonization in children due to serotypes included and not included in current and new pneumococcal conjugate vaccines. View Abstract
Antibody Seronegativity in COVID-19 RT-PCR-Positive Children. View Abstract
Preclinical Immunogenicity and Efficacy of a Multiple Antigen-Presenting System (MAPSTM) SARS-CoV-2 Vaccine. View Abstract
Post-COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection. View Abstract
Phase 1/2 study of a novel 24-valent pneumococcal vaccine in healthy adults aged 18 to 64 years and in older adults aged 65 to 85 years. View Abstract
Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection. View Abstract
Corticosteroids and Other Treatments Administered to Children Tested for SARS-CoV-2 Infection in Emergency Departments. View Abstract
Carrier Proteins Facilitate the Generation of Antipolysaccharide Immunity via Multiple Mechanisms. View Abstract
Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study. View Abstract
Outcomes of SARS-CoV-2-Positive Youths Tested in Emergency Departments: The Global PERN-COVID-19 Study. View Abstract
Induction of T Cell Responses by Vaccination of a Streptococcus pneumoniae Whole-Cell Vaccine. View Abstract
Robust Immune Response Induced by Schistosoma mansoni TSP-2 Antigen Coupled to Bacterial Outer Membrane Vesicles. View Abstract
Optimization of Expression and Purification of Schistosoma mansoni Antigens in Fusion with Rhizavidin. View Abstract
Fostering healthy aging: The interdependency of infections, immunity and frailty. View Abstract
Analysis of Staphylococcus aureus Transcriptome in Pediatric Soft Tissue Abscesses and Comparison to Murine Infections. View Abstract
Prospective cohort study of children with suspected SARS-CoV-2 infection presenting to paediatric emergency departments: a Paediatric Emergency Research Networks (PERN) Study Protocol. View Abstract
Overview of the Nontyphoidal and Paratyphoidal Salmonella Vaccine Pipeline: Current Status and Future Prospects. View Abstract
A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults. View Abstract
Process intensification for production of Streptococcus pneumoniae whole-cell vaccine. View Abstract
Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization. View Abstract
Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice. View Abstract
Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination. View Abstract
Introduction of New Journal Section-Translational Medicine. View Abstract
Th17 responses to pneumococcus in blood and adenoidal cells in children. View Abstract
Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses. View Abstract
Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms. View Abstract
Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome. View Abstract
The immunological mechanisms that control pneumococcal carriage. View Abstract
A Combination of Recombinant Mycobacterium bovis BCG Strains Expressing Pneumococcal Proteins Induces Cellular and Humoral Immune Responses and Protects against Pneumococcal Colonization and Sepsis. View Abstract
The Pneumococcal Type 1 Pilus Genes Are Thermoregulated and Are Repressed by a Member of the Snf2 Protein Family. View Abstract
Antibody-mediated protection against Staphylococcus aureus dermonecrosis and sepsis by a whole cell vaccine. View Abstract
Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy. View Abstract
IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. View Abstract
Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. View Abstract
Rationale and prospects for novel pneumococcal vaccines. View Abstract
Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies. View Abstract
Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model. View Abstract
T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. View Abstract
Effect of nonheme iron-containing ferritin Dpr in the stress response and virulence of pneumococci. View Abstract
The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. View Abstract
Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. View Abstract
Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability. View Abstract
Immunisation against meningococcus B. View Abstract
Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity. View Abstract
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein. View Abstract
Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae. View Abstract
Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. View Abstract
Meta-analysis of bacterial meningitis score validation studies. View Abstract
Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. View Abstract
Streptococcus pneumoniae carriage in the Gaza strip. View Abstract
Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country. View Abstract
A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi. View Abstract
Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity. View Abstract
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. View Abstract
An epigenetic switch mediates bistable expression of the type 1 pilus genes in Streptococcus pneumoniae. View Abstract
Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization. View Abstract
Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA. View Abstract
Next generation pneumococcal vaccines. View Abstract
Serotype replacement in disease after pneumococcal vaccination. View Abstract
T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization. View Abstract
Low risk of bacterial meningitis in children with a positive enteroviral polymerase chain reaction test result. View Abstract
GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis. View Abstract
Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA. View Abstract
Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine. View Abstract
Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development. View Abstract
The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model. View Abstract
Parental Staphylococcus aureus carriage is associated with staphylococcal carriage in young children. View Abstract
Mechanisms in the serotype-independent pneumococcal immunity induced in mice by intranasal vaccination with the cell wall polysaccharide. View Abstract
Pneumococcal capsular polysaccharide structure predicts serotype prevalence. View Abstract
Diagnostic value of immature neutrophils (bands) in the cerebrospinal fluid of children with cerebrospinal fluid pleocytosis. View Abstract
The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers. View Abstract
Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide. View Abstract
Micro-geographic risk factors for malarial infection. View Abstract
Cerebrospinal fluid pleocytosis in children in the era of bacterial conjugate vaccines: distinguishing the child with bacterial and aseptic meningitis. View Abstract
Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. View Abstract
Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice. View Abstract
Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. View Abstract
Interleukin-17A mediates acquired immunity to pneumococcal colonization. View Abstract
Does pneumococcal conjugate vaccine influence Staphylococcus aureus carriage in children? View Abstract
Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. View Abstract
Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage. View Abstract
Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells. View Abstract
In vitro bactericidal activity of Streptococcus pneumoniae and bactericidal susceptibility of Staphylococcus aureus strains isolated from cocolonized versus noncocolonized children. View Abstract
Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. View Abstract
Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. View Abstract
SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model. View Abstract
Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. View Abstract
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. View Abstract
Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. View Abstract
Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. View Abstract
Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae. View Abstract
Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. View Abstract
c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis. View Abstract
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. View Abstract
Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model. View Abstract
CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. View Abstract
Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease? View Abstract
Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. View Abstract
Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant. View Abstract
Development of a model of focal pneumococcal pneumonia in young rats. View Abstract
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. View Abstract
A new prognostic scoring system for meningococcal septic shock in children: comparison with three other scoring systems. View Abstract
Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. View Abstract
Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. View Abstract
Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. View Abstract
Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. View Abstract
Extremity pain and refusal to walk in children with invasive meningococcal disease. View Abstract
Comparison of prediction models for adverse outcome in pediatric meningococcal disease using artificial neural network and logistic regression analyses. View Abstract
Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. View Abstract
Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. View Abstract
Meningococcal disease among children who live in a large metropolitan area, 1981-1996. View Abstract
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. View Abstract
Antibiotic treatment of children with unsuspected meningococcal disease. View Abstract
Endocarditis caused by Corynebacterium diphtheriae: case report and review of the literature. View Abstract
Primary respiratory syncytial virus infection: pathology, immune response, and evaluation of vaccine challenge strains in a new mouse model. View Abstract
Enzyme-linked immunosorbent assay to assess respiratory syncytial virus concentration and correlate results with inflammatory mediators in tracheal secretions. View Abstract
Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expression. View Abstract
Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin. View Abstract
Necrotizing fasciitis of the pharynx following adenotonsillectomy. View Abstract
Clinical and hematologic features do not reliably identify children with unsuspected meningococcal disease. View Abstract
Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein. View Abstract
Cerebrospinal fluid pleocytosis and prognosis in invasive meningococcal disease in children. View Abstract
Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats. View Abstract
Minimum protective serum concentrations of pneumococcal anti-capsular antibodies in infant rats. View Abstract
Multivariable predictive models for adverse outcome of invasive meningococcal disease in children. View Abstract
Psychologic and physiologic reactivity to stressors in eating disordered individuals. View Abstract