Ruth Ann Vleugels, MD
Dermatologist, Dermatology Program
Associate Professor of Dermatology, Harvard Medical School
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Ruth Ann Vleugels, MD
Dermatologist, Dermatology Program
Associate Professor of Dermatology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Virginia
2000
Charlottesville
VA
Medical School
Vanderbilt University School of Medicine
2004
Nashville
TN
Internship
Brigham and Women's Hospital
2005
Boston
MA
Residency
Harvard Dermatology Program
2008
Boston
MA
Fellowship
Beth Israel Deaconess Medical Center
2009
Boston
MA
Certifications
American Board of Dermatology (General)
Publications
Improvement in dermatomyositis-associated muscle disease with anifrolumab. View Abstract
Three-dimensional stereophotogrammetry: an effective tool for detecting disease progression in lupus erythematosus panniculitis. View Abstract
Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis. View Abstract
Efficacy, safety, and target engagement of dazukibart, an IFNß specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. View Abstract
Recent Advances in Juvenile Dermatomyositis: Moving toward Integration of Myositis-Specific Antibody Clinical Phenotypes, IFN-Driven Pathogenesis, and Targeted Therapies. View Abstract
Fracture risk in linear morphea-affected limbs: A pilot retrospective study of adult patients. View Abstract
Innovation in Dermatomyositis. View Abstract
Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus. View Abstract
De novo autoimmune connective tissue disease and mortality in patients treated with anti-programmed death receptor-1 and anti-programmed death-ligand 1 therapy: a population-level cohort study. View Abstract
From traditional to targeted: the changing trajectory of therapies in dermatomyositis. View Abstract
Anifrolumab in recalcitrant cutaneous dermatomyositis: A multicenter retrospective cohort study. View Abstract
Comparison of 3D facial photographs and clinical documentation in patients with craniofacial morphea. View Abstract
Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus. View Abstract
Brepocitinib, a potent and selective TYK2/JAK1 inhibitor: scientific and clinical rationale for dermatomyositis. View Abstract
Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus. View Abstract
Author Correction: International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative. View Abstract
Discoid lupus erythematosus successfully treated with deucravacitinib. View Abstract
Executive summary: Consensus treatment guidelines for the use of methotrexate for inflammatory skin disease in pediatric patients. View Abstract
Rapid Improvement in Recalcitrant Cutaneous Juvenile Dermatomyositis With Anifrolumab Treatment. View Abstract
Depression in patients with Raynaud's phenomenon: A case-control study in the National Institutes of Health's All of Us Research Program. View Abstract
Hyaluronidase Injections for Oral Microstomia in Systemic Sclerosis and Mixed Connective Tissue Disease. View Abstract
Successful Treatment of Keloids and Hypertrophic Scars With Systemic and Intralesional Dupilumab. View Abstract
International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an International Myositis Assessment and Clinical Studies Group (IMACS) initiative. View Abstract
Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea. View Abstract
Increased risk of depression in patients with discoid lupus erythematosus: a nested, case-control study in the All of Us Research Program. View Abstract
Anifrolumab for Adolescent Discoid Lupus Erythematosus. View Abstract
Improvement in mucosal discoid lupus erythematosus with anifrolumab. View Abstract
Utility of magnetic resonance imaging in the diagnosis of eosinophilic fasciitis: A multicenter retrospective cohort study. View Abstract
Diffuse Cutaneous Eruption. View Abstract
Methotrexate for inflammatory skin disease in pediatric patients: Consensus treatment guidelines. View Abstract
Intravenous Immunoglobulin and Dermatomyositis-Associated Venous Thromboembolism. View Abstract
Mepolizumab for refractory eosinophilic fasciitis: a retrospective analysis from two tertiary care centres. View Abstract
Clinical features in adults with acquired cutis laxa: a retrospective review. View Abstract
Distinctive cutaneous features of dermatomyositis in Black adults: A case series. View Abstract
Eosinophilic Fasciitis. View Abstract
Assessment of Clinical Response to Anifrolumab in Patients With Refractory Discoid Lupus Erythematosus. View Abstract
Botulinum toxin for refractory Raynaud's phenomenon: A "how to" guide for pediatric patients. View Abstract
Trial of Intravenous Immune Globulin in Dermatomyositis. View Abstract
Tocilizumab for refractory morphea in adults: A case series. View Abstract
Pilot use of 3-dimensional photography to aid clinical decision-making in craniofacial morphea. View Abstract
Increasing skin of color representation in a medical school dermatology course through student and faculty engagement: The Dermatology IDD Image Verification Ensuring Representation of Skin of Color initiative. View Abstract
Immunologic underpinnings and treatment of morphea. View Abstract
Genetic diagnosis of immune dysregulation can lead to targeted therapy for interstitial lung disease: A case series and single center approach. View Abstract
Cross-sectional characteristics of pediatric-onset discoid lupus erythematosus: Results of a multicenter, retrospective cohort study. View Abstract
Evaluating patient experience and satisfaction with teledermatology for isotretinoin management: a structured qualitative interview study. View Abstract
Dental Anomalies in Parry-Romberg Syndrome: A 40-Year Retrospective Review. View Abstract
Treatment With Mycophenolate Mofetil for Salt-and-Pepper Dyspigmentation Caused by Autoimmune Sclerosing Disease. View Abstract
Crowdsourcing as a means of fundraising for juvenile dermatomyositis. View Abstract
Characteristics and Outcomes of Eosinophilic Fasciitis-Associated Monoclonal Gammopathy. View Abstract
Corrigendum to: A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies. View Abstract
OnabotulinumtoxinA for Systemic Sclerosis-associated Raynaud's Phenomenon: A Multi-Institutional Study on Accessibility and Effectiveness. View Abstract
Race and gender differences in systemic sclerosis: a retrospective multicenter cohort. View Abstract
Tofacitinib as treatment for refractory dermatomyositis: A retrospective study from 2 academic medical centers. View Abstract
Recognition and Management of Cutaneous Connective Tissue Diseases. View Abstract
Use of Tofacitinib, 2%, Ointment for Periorbital Discoid Lupus Erythematosus. View Abstract
A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies. View Abstract
Familial chilblain lupus in a child with heterozygous mutation in SAMHD1 and normal interferon signature. View Abstract
Dermatology education in internal medicine residency programs: A nationwide survey of program directors. View Abstract
Treatment of Severe Multicentric Reticulohistiocytosis With Upadacitinib. View Abstract
Lack of association between tumor necrosis factor-a inhibitor use and exacerbation of lupus erythematosus: A retrospective cohort study. View Abstract
Increased risk of systemic and cardiac sarcoidosis in Black patients with cutaneous sarcoidosis. View Abstract
Characteristics and treatment of silicone granulomas: A retrospective multicenter cohort of 21 patients. View Abstract
The catch-22 of limited Food and Drug Administration approval for connective tissue disease therapies. View Abstract
Clinical features and eosinophilia in pityriasis rubra pilaris: A multicenter cohort. View Abstract
Geographic distribution and environmental triggers of systemic sclerosis cases from 2 large academic tertiary centers in Massachusetts. View Abstract
Challenges of securing insurance approval for oral tofacitinib for the treatment of alopecia areata: a multi-institution retrospective review. View Abstract
Porphyria Cutanea Tarda Masquerading as Systemic Sclerosis: Two Cases Demonstrating an Important Clinical Observation. View Abstract
Early Features of Progressive Hemifacial Atrophy-Clinical and Imaging Findings. View Abstract
Clinical Characteristics of Lupus Erythematosus Panniculitis/Profundus: A Retrospective Review of 61 Patients. View Abstract
Practice gaps in the evaluation of systemic involvement in patients with cutaneous sarcoidosis presenting to a dermatologist: A retrospective review of 48 patients. View Abstract
Strategies for effective medical student education in dermatology during the COVID-19 pandemic. View Abstract
Dermatomyositis: An Update on Diagnosis and Treatment. View Abstract
Mycophenolate Mofetil for Eosinophilic Fasciitis: A Retrospective Analysis From 3 Tertiary Care Centers. View Abstract
Evaluation of the Effectiveness and Tolerability of Mycophenolate Mofetil and Mycophenolic Acid for the Treatment of Morphea. View Abstract
A Comparison of Psoriasis Severity in Pediatric Patients Treated With Methotrexate vs Biologic Agents. View Abstract
A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria. View Abstract
Capecitabine-Related Eruption Mimicking Dermatomyositis in 2 Patients With Metastatic Breast Cancer. View Abstract
Intravenous immunoglobulin for refractory eosinophilic fasciitis: A retrospective analysis from 3 tertiary care centers. View Abstract
Facing Uncertainty. View Abstract
Facing Uncertainty. View Abstract
Willingness-to-pay stated preferences in cutaneous lupus erythematosus: a pilot study. View Abstract
Cutaneous Ulcerations in Anti-MDA5 Dermatomyositis. View Abstract
Augmented reality in dermatology: Are we ready for AR? View Abstract
Systemic Treatment for Clinically Amyopathic Dermatomyositis at 4 Tertiary Care Centers. View Abstract
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. View Abstract
Assessment of Antimalarial Therapy in Patients Who Are Hypersensitive to Hydroxychloroquine. View Abstract
Pityriasis rubra pilaris: A study evaluating patient quality of life in 2 populations. View Abstract
Advances in Cutaneous Lupus Erythematosus and Dermatomyositis: A Report from the 4th International Conference on Cutaneous Lupus Erythematosus-An Ongoing Need for International Consensus and Collaborations. View Abstract
Academic dermatology leadership in the United States -- Addressing the gender gap. View Abstract
Dermatology subspecialty clinic for patients with connective tissue disease impacts diagnosis and treatment: A single-center, retrospective analysis. View Abstract
Lack of response to intravenous sodium thiosulfate in three cases of extensive connective tissue disease-associated calcinosis cutis. View Abstract
Subacute Cutaneous Lupus Erythematosus Induced by Palbociclib. View Abstract
Hidradenitis suppurativa burden of disease tool: Pilot testing of a disease-specific quality of life questionnaire. View Abstract
Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features. View Abstract
Eosinophilic Fasciitis: an Updated Review on Diagnosis and Treatment. View Abstract
Safety of Systemic Agents for the Treatment of Pediatric Psoriasis. View Abstract
Sex and leadership in academic dermatology: A nationwide survey. View Abstract
Characteristics and Alternative Treatment Outcomes of Antimalarial-Refractory Cutaneous Lupus Erythematosus. View Abstract
Antimelanoma Differentiation-associated Gene 5 Dermatomyositis. View Abstract
Asymptomatic papules after breast cancer treatment. View Abstract
Asymptomatic papules after breast cancer treatment. View Abstract
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. View Abstract
Correlation of cutaneous disease activity with type 1 interferon gene signature and interferon ß in dermatomyositis. View Abstract
Expanding the use of the Cutaneous Dermatomyositis Area and Severity Index (CDASI) to nondermatologists. View Abstract
Segmental stiff skin syndrome (SSS): Two additional cases with a positive response to mycophenolate mofetil and physical therapy. View Abstract
Characteristics and treatment of postirradiation morphea: A retrospective multicenter analysis. View Abstract
Unilateral Gottron Papules in a Patient Following a Stroke: Clinical Insights Into the Disease Mechanisms and Pathophysiology of Cutaneous Dermatomyositis. View Abstract
Tofacitinib Citrate for Refractory Cutaneous Dermatomyositis: An Alternative Treatment. View Abstract
Thalidomide and lenalidomide for the treatment of refractory dermatologic conditions. View Abstract
Sharps injuries among US dermatology trainees: A cross-sectional study. View Abstract
Characteristics and treatment of adult-onset linear morphea: A retrospective cohort study of 61 patients at 3 tertiary care centers. View Abstract
Dapsone for treatment of erythema nodosum. View Abstract
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis. View Abstract
Development and Pilot Testing of the Cutaneous Lupus Screening Tool. View Abstract
Epidemiology and Treatment of Eosinophilic Fasciitis: An Analysis of 63 Patients From 3 Tertiary Care Centers. View Abstract
Palliative Therapy for Recalcitrant Cutaneous T-Cell Lymphoma of the Hands and Feet With Low-Dose, High Dose-Rate Brachytherapy. View Abstract
Cutaneous dermatomyositis in the era of biologicals. View Abstract
Epidemiology of concomitant psoriasis and hidradenitis suppurativa (HS): experience of a tertiary medical center. View Abstract
The Value of the Black Box Warning in Dermatology. View Abstract
Severe Tacrolimus-Induced Granulomatous Rosacea Recalcitrant to Oral Tetracyclines. View Abstract
Teledermatology perception differences between urban primary care physicians and dermatologists. View Abstract
Drug-associated dermatomyositis following ipilimumab therapy: a novel immune-mediated adverse event associated with cytotoxic T-lymphocyte antigen 4 blockade. View Abstract
Tense bullae on the palms and soles. View Abstract
Facial erythromelalgia: a rare entity to consider in the differential diagnosis of connective tissue diseases. View Abstract
Clinicopathologic lessons in distinguishing cicatricial alopecia: 7 cases of lichen planopilaris misdiagnosed as discoid lupus. View Abstract
Paraproteinemia-associated scleredema treated successfully with intravenous immunoglobulin. View Abstract
A 52-year-old woman with subcutaneous nodules and abdominal pain. View Abstract
Cumulative ultraviolet radiation flux in adulthood and risk of incident skin cancers in women. View Abstract
Creation of a novel, interdisciplinary, multisite clerkship: "understanding lupus". View Abstract
Cutaneous lupus erythematosus. View Abstract
Treatment options for pityriasis rubra pilaris including biologic agents: a retrospective analysis from an academic medical center. View Abstract
Case records of the Massachusetts General Hospital. Case 39-2013. A 57-year-old woman with painful bullous skin lesions. View Abstract
Multiple tense bullae localized to the right breast in a woman in her seventies. View Abstract
Lupus erythematosus panniculitis-induced facial atrophy: effective treatment with poly-L-lactic acid and hyaluronic acid dermal fillers. View Abstract
Lower-dose thalidomide therapy effectively treats cutaneous lupus erythematosus but is limited by neuropathic toxicity. View Abstract
Psoriasiform reactions to anti-tumor necrosis factor a therapy. View Abstract
Intravenous immunoglobulin for refractory cutaneous dermatomyositis: a retrospective analysis from an academic medical center. View Abstract
Dermatomyositis induced by anti-tumor necrosis factor in a patient with juvenile idiopathic arthritis. View Abstract
Cutaneous dermatomyositis: an updated review of treatment options and internal associations. View Abstract
Methotrexate for the treatment of cutaneous dermatomyositis. View Abstract
Images in clinical medicine. Epidermolysis bullosa acquisita. View Abstract
Diffuse dystrophic calcinosis cutis of the scalp in a patient with scalp discoid lupus erythematosus and systemic lupus erythematosus. View Abstract
Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. View Abstract
Calcinosis cutis: an additional therapy to consider. View Abstract
Panniculitis associated with dermatomyositis and recurrent ovarian cancer. View Abstract
Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature. View Abstract
Management of cutaneous dermatomyositis. View Abstract
A population-based study of acne and body mass index in adolescents. View Abstract
Calciphylaxis: a systematic review of existing and emerging therapies. View Abstract
Identifying when therapy for one skin disease is likely to exacerbate another skin condition. View Abstract
Psoriatic alopecia/alopecia areata-like reactions secondary to anti-tumor necrosis factor-a therapy: a novel cause of noncicatricial alopecia. View Abstract
RNA interference of insulin-related peptide and neuroparsins affects vitellogenesis in the desert locust Schistocerca gregaria. View Abstract
Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-a inhibitor therapy. A study of 16 biopsies. View Abstract
Interactive medical case. A rash hypothesis. View Abstract
The role of octopamine in locusts and other arthropods. View Abstract
The cloning, phylogenetic relationship and distribution pattern of two new putative GPCR-type octopamine receptors in the desert locust (Schistocerca gregaria). View Abstract
Mitochondrial DNA deletions serve as biomarkers of aging in the skin, but are typically absent in nonmelanoma skin cancers. View Abstract
High-throughput mitochondrial genome screening method for nonmelanoma skin cancer using multiplexed temperature gradient capillary electrophoresis. View Abstract
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