Takuto Takahashi, MD, PhD
Attending Physician, Hematopoietic (Stem) Cell Transplant Program
Assistant Professor of Pediatrics, Harvard Medical School
Image
Takuto Takahashi, MD, PhD
Attending Physician, Hematopoietic (Stem) Cell Transplant Program
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Japanese
Education
Graduate School
University of Minnesota College of Pharmacy
Minneapolis
MN
Medical School
University of Yamanashi
Chuo, Yamanashi
Japan
Residency
General Pediatrics
SUNY Downstate Medical Center
2018
Brooklyn
NY
Fellowship
Pediatric Hematology/Oncology
University of Minnesota
2021
Minneapolis
MN
Fellowship
Pediatric Stem Cell Transplantation
Boston Children's Hospital/Dana-Farber Cancer Institute
2022
Boston
MA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Hematology-Oncology)
Professional History
Dr. Takahashi completed Pediatric Residency at SUNY Downstate Medical Center, and he then Pediatric Hematology/Oncology fellowship at the University of Minnesota, where he also completed PhD in Experimental and Clinical Pharmacology with a focus on PKPD modeling and pharmacogenetics. He joined Dana-Farber Cancer Institute in 2021 as a stem cell transplantation fellow before he became a faculty member in 2022. His research focuses on application of PKPD modeling in stem cell transplantation.
Publications
Umbilical Cord Blood Reduced Relapse but Increased Nonrelapse Mortality Compared to Matched Unrelated Donor Transplantation in Pediatric Acute Myeloid Leukemia With Active Disease: A CIBMTR 2008 to 2017 Analysis of Donor Source and Residual Disease. View Abstract
Effects of Total Body Irradiation on Hematopoietic Cell Transplantation Outcomes in Pediatric Acute Myeloid Leukemia with Prior Central Nervous System Involvement. View Abstract
Individualized rabbit anti-thymocyte globulin dosing in adult haploidentical hematopoietic cell transplantation with high-risk hematologic malignancy: Exposure-response analysis and population pharmacokinetics simulations. View Abstract
Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events. View Abstract
Population Pharmacokinetic Model of Intravenous Busulfan in Hematopoietic Cell Transplantation: Systematic Review and Comparative Simulations. View Abstract
Population Pharmacokinetics of Total Rabbit Anti-thymocyte Globulin in Non-obese Adult Patients Undergoing Hematopoietic Cell Transplantation for Hematologic Malignancy. View Abstract
T-cell depleted haploidentical hematopoietic cell transplantation for pediatric malignancy. View Abstract
Influence of Renal Function on Phosphoramide Mustard Exposure: A Nonlinear Mixed-Effects Analysis. View Abstract
Comparison of Dose Adjustment Strategies for Obesity in High-dose Cyclophosphamide Among Adult Hematopoietic Cell Transplantation Recipients: Pharmacokinetic Analysis. View Abstract
Therapeutic Leukapheresis in Pediatric Leukemia: Utilization Trend and Early Outcomes in a US Nationwide Cohort. View Abstract
Predictive Value of C-Reactive Protein and Albumin for Temporal Within-Individual Pharmacokinetic Variability of Voriconazole in Pediatric Patients Undergoing Hematopoietic Cell Transplantation. View Abstract
Effects of cyclophosphamide related genetic variants on clinical outcomes of adult hematopoietic cell transplant patients. View Abstract
Busulfan dose Recommendation in Inherited Metabolic Disorders: Population Pharmacokinetic Analysis. View Abstract
CYP2C19 Phenotype and Body Weight-Guided Voriconazole Initial Dose in Infants and Children after Hematopoietic Cell Transplantation. View Abstract
CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant. View Abstract
Late-Onset Acute and Chronic Graft-versus-Host Disease in Children: Clinical Features and Response to Therapy. View Abstract
Higher Fludarabine and Cyclophosphamide Exposures Lead to Worse Outcomes in Reduced-Intensity Conditioning Hematopoietic Cell Transplantation for Adult Hematologic Malignancy. View Abstract
Successful Rituximab Monotherapy in Advanced-stage, Epstein-Barr Virus-positive Diffuse Large B-Cell Lymphoma in an Adolescent With Systemic Juvenile Idiopathic Arthritis. View Abstract
Outcomes of chronic graft-versus-host disease following matched sibling donor versus umbilical cord blood transplant. View Abstract
Impact of Obesity on Voriconazole Pharmacokinetics among Pediatric Hematopoietic Cell Transplant Recipients. View Abstract
Pharmacogenomics of COVID-19 therapies. View Abstract
Safety and efficacy of gamma-secretase inhibitor nirogacestat (PF-03084014) in desmoid tumor: Report of four pediatric/young adult cases. View Abstract
In-hospital mortality of hematopoietic stem cell transplantation among children with nonmalignancies: A nationwide study in the United States from 2000 to 2012. View Abstract
Factors Associated With Mechanical Ventilation Use in Children With Sickle Cell Disease and Acute Chest Syndrome. View Abstract
Childhood leptospirosis in an industrialized country: Population-based study in Okinawa, Japan. View Abstract
Acute chest syndrome among children hospitalized with vaso-occlusive crisis: A nationwide study in the United States. View Abstract
'Down-triage' for children with abnormal vital signs: evaluation of a new triage practice at a paediatric emergency department in Japan. View Abstract
Development of coronary artery lesions in indolent Kawasaki disease following initial spontaneous defervescence: a retrospective cohort study. View Abstract