Talal Chatila, MD
Immunologist, Division of Immunology
Denise and David Bunning Professor of Pediatrics, Harvard Medical School
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Talal Chatila, MD
Immunologist, Division of Immunology
Denise and David Bunning Professor of Pediatrics, Harvard Medical School
Medical Services
Education
Medical School
American University of Beirut
1994
Beirut
Lebanon
Professional History
Dr. Chatila serves as an expert for the Department of Allergy and Immunology for Boston Children's Hospital Precision Medicine Service. For more information about the Precision Medicine Service please visit bostonchildrens.org/precisionmed.
Publications
Functional diversification of dietary plant small molecules by the gut microbiome. View Abstract
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses. View Abstract
RELMß sets the threshold for microbiome-dependent oral tolerance. View Abstract
DOCK8 deficiency due to a deep intronic variant in two kindreds with hyper-IgE syndrome. View Abstract
Notch4 regulatory T cells and SARS-CoV-2 viremia shape COVID19 survival outcome. View Abstract
Pathogenic mechanisms in the evolution of food allergy. View Abstract
Immunological biomarkers associated with survival in a cohort of Argentinian patients with common variable immunodeficiency. View Abstract
The Impact of Russia-Ukraine geopolitical conflict on the air quality and toxicological properties of ambient PM2.5 in Milan, Italy. View Abstract
Age-specific Metabolomic profiles in children with food allergy. View Abstract
Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop. View Abstract
Regulatory T cells in allergic inflammation. View Abstract
Regulatory T cells in dominant immunologic tolerance. View Abstract
The opposing effects of two gene defects in STX11 and SLP76 on the disease in a patient with an inborn error of immunity. View Abstract
Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6. View Abstract
The IL-4Ra Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice. View Abstract
Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis. View Abstract
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children. View Abstract
Regulatory T-cells in asthma. View Abstract
An embarrassment of riches: ROR?t+ antigen-presenting cells in peripheral tolerance. View Abstract
CPHEN-016: Comprehensive phenotyping of human regulatory T cells. View Abstract
A Stk4-Foxp3-NF-?B p65 transcriptional complex promotes Treg cell activation and homeostasis. View Abstract
SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children. View Abstract
Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report. View Abstract
A common IL-4 receptor variant promotes asthma severity via a Treg cell GRB2-IL-6-Notch4 circuit. View Abstract
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. View Abstract
CPHEN-014: Comprehensive phenotyping of mouse regulatory T cells relevant to viral infections. View Abstract
Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children. View Abstract
Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. View Abstract
Recent patents in allergy and immunology: Method for treating asthma or allergic disease via anti-Notch4 mAb. View Abstract
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children. View Abstract
Editorial: IPEX 2020: An Expanding Disease Spectrum and Novel Precision Therapies. View Abstract
Assessing the safety of bioactive ingredients in infant formula that affect the immune system: recommendations from an expert panel. View Abstract
Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency. View Abstract
Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation. View Abstract
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis. View Abstract
Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency. View Abstract
Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. View Abstract
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. View Abstract
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. View Abstract
Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming. View Abstract
Essential functions of regulatory T cell TGF-ß1 revealed by differential gene-targeting approaches. View Abstract
Stepwise Reversal of Immune Dysregulation Due to STAT1 Gain-of-Function Mutation Following Ruxolitinib Bridge Therapy and Transplantation. View Abstract
Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
The microbial origins of food allergy. View Abstract
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. View Abstract
The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. View Abstract
Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. View Abstract
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. View Abstract
Dietary and Microbial Determinants in Food Allergy. View Abstract
Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. View Abstract
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. View Abstract
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. View Abstract
Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. View Abstract
Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. View Abstract
Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. View Abstract
The immunologic features of patients with early-onset and polyautoimmunity. View Abstract
Hypomorphic DOCK8 deletion causes hypereosinophilic syndrome. View Abstract
ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients. View Abstract
Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma. View Abstract
Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1. View Abstract
Mechanisms of Dupilumab. View Abstract
Regulatory T Cells: the Many Faces of Foxp3. View Abstract
Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. View Abstract
Functional reprogramming of regulatory T cells in the absence of Foxp3. View Abstract
Regulation of oral immune tolerance by the microbiome in food allergy. View Abstract
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. View Abstract
Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. View Abstract
Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. View Abstract
Treatment of severe persistent asthma with IL-6 receptor blockade. View Abstract
Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". View Abstract
Hematopoietic Stem Cell Transplantation in Patients with Heterozygous STAT1 Gain-of-Function Mutation. View Abstract
EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease. View Abstract
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. View Abstract
Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function. View Abstract
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. View Abstract
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. View Abstract
A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles. View Abstract
Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases. View Abstract
A young girl with severe cerebral fungal infection due to card 9 deficiency. View Abstract
The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. View Abstract
International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. View Abstract
A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells. View Abstract
DOCK8 Deficiency Presenting as an IPEX-Like Disorder. View Abstract
Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content. View Abstract
Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. View Abstract
Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene. View Abstract
Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. View Abstract
DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. View Abstract
Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content. View Abstract
DOCK8 deficiency: Insights into pathophysiology, clinical features and management. View Abstract
Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. View Abstract
CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder. View Abstract
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. View Abstract
Deciphering the black box of food allergy mechanisms. View Abstract
The role of the gut microbiota in food allergy. View Abstract
Advances in food allergy oral immunotherapy: toward tolerance. View Abstract
Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. View Abstract
Regulatory T cells in allergic diseases. View Abstract
Innate Immunity in Asthma. View Abstract
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. View Abstract
Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1. View Abstract
Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. View Abstract
CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis. View Abstract
Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. View Abstract
IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. View Abstract
Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. View Abstract
T Regulatory Cell Biology in Health and Disease. View Abstract
Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. View Abstract
Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease. View Abstract
Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. View Abstract
The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies. View Abstract
Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling. View Abstract
MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. View Abstract
Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. View Abstract
Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder. View Abstract
Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. View Abstract
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita. View Abstract
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. View Abstract
The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. View Abstract
DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. View Abstract
Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. View Abstract
Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. View Abstract
Regulatory T cells: exosomes deliver tolerance. View Abstract
Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. View Abstract
Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. View Abstract
Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. View Abstract
Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. View Abstract
Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency. View Abstract
Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. View Abstract
Food allergy: Insights into etiology, prevention, and treatment provided by murine models. View Abstract
Editorial: Optimizing iTreg differentiation: STATs in the balance. View Abstract
Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. View Abstract
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. View Abstract
Primary Immune Deficiency Treatment Consortium (PIDTC) report. View Abstract
Fox family ties. View Abstract
Inhaled alpha1-antitrypsin administered to treat pneumatocele in autosomal dominant hyperimmunoglobulin E syndrome. View Abstract
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. View Abstract
Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. View Abstract
Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder. View Abstract
IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. View Abstract
T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFß) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. View Abstract
Foxp3: shades of tolerance. View Abstract
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. View Abstract
Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. View Abstract
MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. View Abstract
Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. View Abstract
Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. View Abstract
T-regulatory cells in primary immune deficiencies. View Abstract
T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3. View Abstract
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. View Abstract
Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening. View Abstract
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. View Abstract
IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. View Abstract
Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. View Abstract
Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. View Abstract
In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. View Abstract
GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. View Abstract
DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction. View Abstract
Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. View Abstract
Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. View Abstract
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. View Abstract
Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. View Abstract
Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome. View Abstract
Regulatory T cells: key players in tolerance and autoimmunity. View Abstract
Crouching tigers, hidden dragons: the interplay of pathogens and hosts. View Abstract
Impaired memory of eyeblink conditioning in CaMKIV KO mice. View Abstract
A central role for induced regulatory T cells in tolerance induction in experimental colitis. View Abstract
Immunoglobulin replacement therapy in children. View Abstract
Molecular mechanisms of regulatory T cell development. View Abstract
T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. View Abstract
Molecular mechanisms of regulatory T-cell development. View Abstract
The regulatory T cell transcriptosome: E pluribus unum. View Abstract
Extra-intestinal manifestations of gastro-intestinal allergy: effector and regulatory T cells in the balance. View Abstract
FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. View Abstract
Regulatory T cells dynamically control the primary immune response to foreign antigen. View Abstract
Regulatory T cell development in the absence of functional Foxp3. View Abstract
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. View Abstract
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. View Abstract
Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. View Abstract
Selective engagement of plasticity mechanisms for motor memory storage. View Abstract
Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. View Abstract
Role of regulatory T cells in human diseases. View Abstract
Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. View Abstract
Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation. View Abstract
Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice. View Abstract
NF-kappaB and the innate immune response in the respiratory distress syndrome of the newborn: commentary on the article by Cheah et al. on page 616. View Abstract
Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells. View Abstract
Interleukin-4 receptor signaling pathways in asthma pathogenesis. View Abstract
Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. View Abstract
Calcium calmodulin-dependent protein kinase IV is required for fear memory. View Abstract
Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. View Abstract
Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. View Abstract
CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells. View Abstract
Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy. View Abstract
Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias. View Abstract
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. View Abstract
Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. View Abstract
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. View Abstract
Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. View Abstract
Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. View Abstract
Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. View Abstract
Light microscopic, immunophenotypic, and molecular genetic study of autoimmune lymphoproliferative syndrome caused by fas mutation. View Abstract
Calcium-dependent activation of TNF family gene expression by Ca2+/calmodulin kinase type IV/Gr and calcineurin. View Abstract
Genetics of atopic diseases. View Abstract
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. View Abstract
Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene. View Abstract
The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication. View Abstract
Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. View Abstract
Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. View Abstract
HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. View Abstract
A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. View Abstract
Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. View Abstract
Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). View Abstract
Induction of interleukin-6 after stimulation of human B-cell CD21 by Epstein-Barr virus glycoproteins gp350 and gp220. View Abstract
Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID). View Abstract
Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. View Abstract
Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. View Abstract
A syndrome involving immunodeficiency and multiple intestinal atresias. View Abstract
Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent kinase-Gr. View Abstract
Superantigens activate HIV-1 gene expression in monocytic cells. View Abstract
Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells. View Abstract
A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. View Abstract
Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. View Abstract
Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. View Abstract
Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling. View Abstract
Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells. View Abstract
The T cell receptor associated CD3-epsilon protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif. View Abstract
Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1. View Abstract
Molecular basis of a multiple lymphokine deficiency in a patient with severe combined immunodeficiency. View Abstract
A protein of the AP-1 family is a component of nuclear factor of activated T cells. View Abstract
Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. View Abstract
Staphylococcal superantigens as inducers of signal transduction in MHC class II-positive cells. View Abstract
Signal transduction by microbial superantigens via MHC class II molecules. View Abstract
Severe combined immunodeficiency with selective T-cell cytokine genes. View Abstract
Role of protein kinase activation in the induction of B cell adhesion by MHC class II ligands. View Abstract
Association of neuronal pp60c-src with growth cone glycoproteins of rat brain. View Abstract
Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells. View Abstract
Engagement of MHC class I molecules induces cell adhesion via both LFA-1-dependent and LFA-1-independent pathways. View Abstract
Role of protein tyrosine phosphorylation in monokine induction by the staphylococcal superantigen toxic shock syndrome toxin-1. View Abstract
Developmental regulation of transmembrane signaling via the T cell antigen receptor/CD3 complex in human T lymphocytes. View Abstract
Superantigens. View Abstract
Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. View Abstract
Novel immune deficiencies: defective transcription of lymphokine genes. View Abstract
Expression of a neuronal Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in rat thymus. View Abstract
Transcriptional activation of IL-1 beta and tumor necrosis factor-alpha genes by MHC class II ligands. View Abstract
Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells. View Abstract
Novel immune deficiencies: defective transcription of lymphokine genes. View Abstract
Toxic shock syndrome toxin-1, toxic shock, and the immune system. View Abstract
Primary combined immunodeficiency resulting from defective transcription of multiple T-cell lymphokine genes. View Abstract
Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion. View Abstract
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. View Abstract
T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes. View Abstract
Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules. View Abstract
The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex-unrestricted cognate T/B cell interaction. View Abstract
Mechanisms of T cell activation by the calcium ionophore ionomycin. View Abstract
Recombinant interleukin 2 therapy in severe combined immunodeficiency disease. View Abstract
Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. View Abstract
Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. View Abstract
An immunodeficiency characterized by defective signal transduction in T lymphocytes. View Abstract
Proliferation of highly purified T cells in response to signaling via surface receptors requires cell-cell contact. View Abstract
Phosphorylation of T cell membrane proteins by activators of protein kinase C. View Abstract
Toxic shock syndrome toxin-1 induces inositol phospholipid turnover, protein kinase C translocation, and calcium mobilization in human T cells. View Abstract
Requirement for mitogen, T cell-accessory cell contact, and interleukin 1 in the induction of resting T-cell proliferation. View Abstract
Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. View Abstract
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