Thomas Martin, MD
Pulmonologist, Division of Pulmonary Medicine
Assistant Professor of Pediatrics, Harvard Medical School
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Thomas Martin, MD
Pulmonologist, Division of Pulmonary Medicine
Assistant Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Marquette University
1874
Milwaukee
WI
Medical School
University of Wisconsin Medical School
1978
Madison
WI
Internship
Pediatrics
University of California at Irvine Medical Center
1980
Irvine
CA
Residency
Pediatrics
University of California at San Francisco Medical Center
1981
San Francisco
CA
Fellowship
Pulmonary Medicine
Boston Children's Hospital
1986
Boston
MA
Certifications
American Board of Pediatrics (Pulmonology)
Publications
Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. View Abstract
Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures. View Abstract
Mechanisms of acute respiratory distress syndrome in children and adults: a review and suggestions for future research. View Abstract
The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. View Abstract
Phenazine content in the cystic fibrosis respiratory tract negatively correlates with lung function and microbial complexity. View Abstract
Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. View Abstract
Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide. View Abstract
Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. View Abstract
Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. View Abstract
The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. View Abstract
Clinically useful spirometry in preschool-aged children: evaluation of the 2007 American Thoracic Society Guidelines. View Abstract
Febrile-range hyperthermia augments lipopolysaccharide-induced lung injury by a mechanism of enhanced alveolar epithelial apoptosis. View Abstract
Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa. View Abstract
Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. View Abstract
Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice. View Abstract
Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. View Abstract
Animal models of acute lung injury. View Abstract
Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin. View Abstract
Essential role of MMP-12 in Fas-induced lung fibrosis. View Abstract
The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. View Abstract
Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. View Abstract
Inflammatory cells as a source of airspace extracellular superoxide dismutase after pulmonary injury. View Abstract
Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. View Abstract
Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation. View Abstract
Sweat testing infants detected by cystic fibrosis newborn screening. View Abstract
Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. View Abstract
TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. View Abstract
Mechanical ventilation affects lung function and cytokine production in an experimental model of endotoxemia. View Abstract
Blockade of the Fas/FasL system improves pneumococcal clearance from the lungs without preventing dissemination of bacteria to the spleen. View Abstract
Clinical issues and research in respiratory failure from severe acute respiratory syndrome. View Abstract
Direct lung injury by bacteria: clarifying the tools of the trade. View Abstract
Enhancement of the endotoxin recognition pathway by ventilation with a large tidal volume in rabbits. View Abstract
Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. View Abstract
Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription. View Abstract
Tissue-specific mechanisms control the retention of IL-8 in lungs and skin. View Abstract
The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. View Abstract
Cytokine balance in the lungs of patients with acute respiratory distress syndrome. View Abstract
Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: potential role for a gut-lung axis of inflammation. View Abstract
CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. View Abstract
Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis. View Abstract
Genetic variability in pulmonary physiological, cellular, and antibody responses to antigen in mice. View Abstract
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. View Abstract
Mast cell activation is not required for induction of airway hyperresponsiveness by ozone in mice. View Abstract
The role of leukocyte emigration and IL-8 on the development of lipopolysaccharide-induced lung injury in rabbits. View Abstract
Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. View Abstract
Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. View Abstract
Persistence of pulmonary pathology and abnormal lung function in IL-3/GM-CSF/IL-5 beta c receptor-deficient mice despite correction of alveolar proteinosis after BMT. View Abstract
Pulmonary and systemic inflammatory responses in rabbits with gram-negative pneumonia. View Abstract
Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2). View Abstract
T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice. View Abstract
Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. View Abstract
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. View Abstract
An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. View Abstract
Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. View Abstract
Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response. View Abstract
Active anaphylaxis in IgE-deficient mice. View Abstract
Serotonin-induced pulmonary responses are mediated by the 5-HT2 receptor in the mouse. View Abstract
Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. View Abstract
Mast cell activation enhances airway responsiveness to methacholine in the mouse. View Abstract
Recombinant murine interferon-gamma reversibly activates rat alveolar macrophages to kill Legionella pneumophila. View Abstract
The effect of type-specific polysaccharide capsule on the clearance of group B streptococci from the lungs of infant and adult rats. View Abstract
Alveolar macrophage function in rats with severe protein calorie malnutrition. Arachidonic acid metabolism, cytokine release, and antimicrobial activity. View Abstract
The trachea and esophagus after repair of esophageal atresia and distal fistula: computed tomographic observations. View Abstract
Impaired clearance of aerosolized Legionella pneumophila in corticosteroid-treated rats: a model of Legionnaires' disease in the compromised host. View Abstract
Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. View Abstract
Relationship between maximal expiratory flows and lung volumes in growing humans. View Abstract
Pulmonary responses to bronchoconstrictor agonists in the mouse. View Abstract
Lung antibacterial defense mechanisms in infant and adult rats: implications for the pathogenesis of group B streptococcal infections in the neonatal lung. View Abstract
Controlled clinical trial of methylprednisolone in patients with chronic bronchitis and acute respiratory insufficiency. View Abstract