Ulrike Gerdemann, MD
Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Instructor of Pediatrics, Harvard Medical School
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Ulrike Gerdemann, MD
Physician, Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Instructor of Pediatrics, Harvard Medical School
Medical Services
Languages
German
Education
Medical School
Charité – Universitätsmedizin Berlin
Berlin
Germany
Residency
Pediatrics
Boston Combined Residency Program (BCRP)
Boston
MA
Fellowship
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Boston
MA
Publications
Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease. View Abstract
Human OX40L-CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity. View Abstract
B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates. View Abstract
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. View Abstract
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. View Abstract
Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation. View Abstract
Uncovering CD4+ T-cell exhaustion in B-ALL. View Abstract
Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform. View Abstract
B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations. View Abstract
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans. View Abstract
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease. View Abstract
Activity of the Highly Specific RET Inhibitor Selpercatinib (LOXO-292) in Pediatric Patients With Tumors Harboring RET Gene Alterations. View Abstract
Epstein-Barr Virus (EBV)-derived BARF1 encodes CD4- and CD8-restricted epitopes as targets for T-cell immunotherapy. View Abstract
Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state. View Abstract
The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. View Abstract
The epigenetic landscape of T cell exhaustion. View Abstract
Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT. View Abstract
Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy. View Abstract
Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant. View Abstract
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant. View Abstract
Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies. View Abstract
Immunotherapeutic strategies to prevent and treat human herpesvirus 6 reactivation after allogeneic stem cell transplantation. View Abstract
Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections. View Abstract
The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. View Abstract
Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: assessment of safety and immunologic responses in patients. View Abstract
Cytotoxic T lymphocytes simultaneously targeting multiple tumor-associated antigens to treat EBV negative lymphoma. View Abstract
Improving T-cell therapy for relapsed EBV-negative Hodgkin lymphoma by targeting upregulated MAGE-A4. View Abstract
Generation of multivirus-specific T cells to prevent/treat viral infections after allogeneic hematopoietic stem cell transplant. View Abstract
Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers. View Abstract
Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex). View Abstract
Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host. View Abstract
Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. View Abstract
[Differentiation of peripheral and central hyperalgesic effects of systemic procaine]. View Abstract
Attenuated Yersinia pseudotuberculosis carrier vaccine for simultaneous antigen-specific CD4 and CD8 T-cell induction. View Abstract