Wen-Hann Tan, BMBS
Attending Physician, Division of Genetics and Genomics
Associate Professor of Pediatrics, Harvard Medical School
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Wen-Hann Tan, BMBS
Attending Physician, Division of Genetics and Genomics
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Medical School
University of Nottingham Medical School
1998
Nottingham
United Kingdom
Internship
Internal Medicine/General Surgery/Pediatrics
University Hospital
1999
Nottingham
United Kingdom
Residency
General Pediatrics
West Suffolk Hospital & Addenbrooke's Hospital
2001
East Anglia
United Kingdom
Residency
Pediatrics
Massachusetts General Hospital
2003
Boston
MA
Fellowship
Clinical Genetics
Harvard Medical School Genetics Training Program
2006
Boston
MA
Certifications
American Board of Medical Genetics and Genomics (Clinical Genetics)
American Board of Pediatrics (General)
Publications
Developmental milestones and daily living skills in individuals with Angelman syndrome. View Abstract
Gaboxadol in angelman syndrome: A double-blind, parallel-group, randomized placebo-controlled phase 3 study. View Abstract
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications. View Abstract
DNA methylation signature associated with Bohring-Opitz syndrome: a new tool for functional classification of variants in ASXL genes. View Abstract
Methylation analysis and developmental profile of two individuals with Angelman syndrome due to mosaic imprinting defects. View Abstract
Anxiety in Angelman Syndrome. View Abstract
KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum. View Abstract
Proposed criteria for nevoid basal cell carcinoma syndrome in children assessed using statistical optimization. View Abstract
Clinical Characterization of Epilepsy in Children With Angelman Syndrome. View Abstract
Evaluating Sleep Disturbances in Children With Rare Genetic Neurodevelopmental Syndromes. View Abstract
The Unrecognized Mortality Burden of Genetic Disorders in Infancy. View Abstract
Electrophysiological Abnormalities in Angelman Syndrome Correlate With Symptom Severity. View Abstract
Clinical, neuroimaging, and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability. View Abstract
Developmental Skills of Individuals with Angelman Syndrome Assessed Using the Bayley-III. View Abstract
A dyadic approach to the delineation of diagnostic entities in clinical genomics. View Abstract
The STARS Phase 2 Study: A Randomized Controlled Trial of Gaboxadol in Angelman Syndrome. View Abstract
Exome sequencing identifies novel missense and deletion variants in RTN4IP1 associated with optic atrophy, global developmental delay, epilepsy, ataxia, and choreoathetosis. View Abstract
Cleft Lip and Palate in Ectodermal Dysplasia. View Abstract
Angelman syndrome genotypes manifest varying degrees of clinical severity and developmental impairment. View Abstract
Genetic diagnoses and associated anomalies in fetuses prenatally diagnosed with esophageal atresia. View Abstract
Impaired dentin mineralization, supernumerary teeth, hypoplastic mandibular condyles with long condylar necks, and a TRPS1 mutation. View Abstract
De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy. View Abstract
Imprinted genes in clinical exome sequencing: Review of 538 cases and exploration of mouse-human conservation in the identification of novel human disease loci. View Abstract
ZMYND11-related syndromic intellectual disability: 16 patients delineating and expanding the phenotypic spectrum. View Abstract
Neurodevelopmental profile of siblings with Angelman syndrome due to pathogenic UBE3A variants. View Abstract
TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities. View Abstract
An observational study of pediatric healthcare burden in Angelman syndrome: results from a real-world study. View Abstract
Infant mortality: the contribution of genetic disorders. View Abstract
Genome Sequencing Identifies the Pathogenic Variant Missed by Prior Testing in an Infant with Marfan Syndrome. View Abstract
Healthcare burden among individuals with Angelman syndrome: Findings from the Angelman Syndrome Natural History Study. View Abstract
Maladaptive behaviors in individuals with Angelman syndrome. View Abstract
Prenatal imaging throughout gestation in Beckwith-Wiedemann syndrome. View Abstract
Electrophysiological Phenotype in Angelman Syndrome Differs Between Genotypes. View Abstract
Clinical diversity of MYH7-related cardiomyopathies: Insights into genotype-phenotype correlations. View Abstract
Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed UBE3A isoform. View Abstract
Recognizing and Managing Children with a Pediatric Cancer Predisposition Syndrome: A Guide for the Pediatrician. View Abstract
Acute Pancreatitis in a Patient with Maple Syrup Urine Disease: A Management Paradox. View Abstract
Defining the phenotypic spectrum of SLC6A1 mutations. View Abstract
Expanding the neurodevelopmental phenotype of PURA syndrome. View Abstract
A randomized controlled trial of levodopa in patients with Angelman syndrome. View Abstract
Liver Failure as the Presentation of Ornithine Transcarbamylase Deficiency in a 13-Month-Old Female. View Abstract
Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. View Abstract
Pharmacological therapies for Angelman syndrome. View Abstract
Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations. View Abstract
Clinical management of patients with ASXL1 mutations and Bohring-Opitz syndrome, emphasizing the need for Wilms tumor surveillance. View Abstract
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. View Abstract
Commentary. View Abstract
PTEN hamartoma tumour syndrome: early tumour development in children. View Abstract
Copy number variation plays an important role in clinical epilepsy. View Abstract
If not Angelman, what is it? A review of Angelman-like syndromes. View Abstract
Skeletal dysplasia, global developmental delay, and multiple congenital anomalies in a 5-year-old boy-report of the second family with B3GAT3 mutation and expansion of the phenotype. View Abstract
Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities. View Abstract
In: Rimoin DL, Pyeritz RE, Korf BR, editors. Emery and Rimoin's Principles and Practice of Medical Genetics View Abstract
CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. View Abstract
Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database. View Abstract
Pitt-Hopkins syndrome should be in the differential diagnosis for males presenting with an ATR-X phenotype. View Abstract
A therapeutic trial of pro-methylation dietary supplements in Angelman syndrome. View Abstract
Angelman syndrome: Mutations influence features in early childhood. View Abstract
A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. View Abstract
A neurodevelopmental survey of Angelman syndrome with genotype-phenotype correlations. View Abstract
Epilepsy in Prader-Willi syndrome: clinical characteristics and correlation to genotype. View Abstract
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. View Abstract
Developmental and degenerative features in a complicated spastic paraplegia. View Abstract
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. View Abstract
Diagnostic utility of array-based comparative genomic hybridization in a clinical setting. View Abstract
The spectrum of vascular anomalies in patients with PTEN mutations: implications for diagnosis and management. View Abstract
Identification of a novel polymorphism--the duplication of the NPHP1 (nephronophthisis 1) gene. View Abstract
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. View Abstract
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. View Abstract
A putative new locus for an autosomal recessive cerebellar ataxia syndrome on chromosome 22q11. View Abstract
Cockayne syndrome: the developing phenotype. View Abstract
Hypothelia, syndactyly, and ear malformation--a variant of the scalp-ear-nipple syndrome?: Case report and review of the literature. View Abstract
Dose regimen for vancomycin not needing serum peak levels? View Abstract
Bohring-Opitz Syndrome View Abstract