Yee-Ming Chan, MD, PhD
Medical Director, Behavioral Health, Endocrinology, Gynecology, and Urology (BEING-U) Program; Attending Physician, Division of Endocrinology
Associate Professor of Pediatrics, Harvard Medical School
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Yee-Ming Chan, MD, PhD
Medical Director, Behavioral Health, Endocrinology, Gynecology, and Urology (BEING-U) Program; Attending Physician, Division of Endocrinology
Associate Professor of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
BS, Biology
Yale University
1993
New Haven
CT
Graduate School
Phd, Genetics
University of California, San Francisco
2000
San Francisco
CA
Medical School
University of California, San Francisco
2002
San Francisco
CA
Internship
Pediatrics
University of California, San Francisco
2003
San Francisco
CA
Residency
Pediatrics
University of California, San Francisco
2005
San Francisco
CA
Fellowship
Pediatric Endocrinology
Boston Children's Hospital
2008
Boston
MA
Certifications
American Board of Pediatrics (Endocrinology)
Professional History
I am a pediatric endocrinologist and translational researcher with an interest in the reproductive endocrine system. In both my clinical practice and my research, I focus on how the reproductive endocrine system develops and functions before birth, in infancy, at puberty, and through adolescence and adulthood. I treat and study conditions that interfere with the function of the reproductive endocrine system; these conditions can cause differences of sex development and development of the genitals, precocious or delayed puberty, and/or issues with fertility. My research focuses on the causes of these conditions, the impact of these conditions on patients, developing potential new diagnostic tests, and evaluating treatments for these conditions.
Approach to Care
I pursued training in both medicine and scientific research to combine my love of biology with my desire to help others. My goal as a physician is to give patients and families the information and guidance they need to make the best decisions for themselves. My goal as a scientist is to study patients with reproductive endocrine conditions to answer both basic questions about how the reproductive endocrine system works and how puberty starts, and practical questions that can have a direct impact on patient care.
Publications
Age at Menarche and Coronary Artery Disease Risk: Divergent Associations with Different Sources of Variation. View Abstract
Contributions of Common Genetic Variants to Constitutional Delay of Puberty and Idiopathic Hypogonadotropic Hypogonadism. View Abstract
Age at Menarche and Coronary Artery Disease Risk: Divergent Associations with Different Sources of Variation. View Abstract
Independent effects of testosterone, estradiol, and sex chromosomes on gene expression in immune cells of trans- and cisgender individuals. View Abstract
Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome. View Abstract
Psychosocial Functioning in Transgender Youth after 2 Years of Hormones. View Abstract
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty. View Abstract
Exploring Factors Associated with Decisions about Feminizing Genitoplasty in Differences of Sex Development. View Abstract
Stigma, Intrusiveness, and Distress in Parents of Children with a Disorder/Difference of Sex Development. View Abstract
Evidence From Men for Ovary-independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome. View Abstract
Surgical experiences in adolescents and young adults with differences of sex development: A qualitative examination. View Abstract
The effect of gender-affirming hormone treatment on serum creatinine in transgender and gender-diverse youth: implications for estimating GFR. View Abstract
Decisional regret about surgical and non-surgical issues after genitoplasty among caregivers of female infants with CAH. View Abstract
Lipoprotein subtypes after testosterone therapy in transmasculine adolescents. View Abstract
Timing of Pubertal Onset in Girls and Boys With Constitutional Delay. View Abstract
A Comparison of Demographic and Psychosocial Characteristics Between Transgender Youth Enrolling Versus Not Enrolling in a Multisite Study. View Abstract
Growth in Transgender/Gender-Diverse Youth in the First Year of Treatment With Gonadotropin-Releasing Hormone Agonists. View Abstract
Distress Trajectories for Parents of Children With DSD: A Growth Mixture Model. View Abstract
Association of High-Density Lipoprotein Cholesterol With Sex Steroid Treatment in Transgender and Gender-Diverse Youth. View Abstract
Histrelin Implants for Suppression of Puberty in Youth with Gender Dysphoria: A Comparison of 50 mcg/Day (Vantas) and 65 mcg/Day (SupprelinLA). View Abstract
Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. View Abstract
Psychosocial Functioning Among Children With and Without Differences of Sex Development. View Abstract
Fertility Discussions: Perspectives of Adolescents and Young Adults With Differences of Sex Development. View Abstract
An Unusual Cause of Secondary Amenorrhea in an Adolescent: Expanding the Differential. View Abstract
Illness Uncertainty Longitudinally Predicts Distress Among Caregivers of Children Born With DSD. View Abstract
Psychosocial Characteristics of Transgender Youth Seeking Gender-Affirming Medical Treatment: Baseline Findings From the Trans Youth Care Study. View Abstract
TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. View Abstract
Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay. View Abstract
Low Bone Mineral Density in Early Pubertal Transgender/Gender Diverse Youth: Findings From the Trans Youth Care Study. View Abstract
Post-operative complications following feminizing genitoplasty in moderate to severe genital atypia: Results from a multicenter, observational prospective cohort study. View Abstract
Physiological and Metabolic Characteristics of a Cohort of Transgender and Gender-Diverse Youth in the United States. View Abstract
PRACTICE VARIATION IN THE MANAGEMENT OF GIRLS AND BOYS WITH DELAYED PUBERTY. View Abstract
Creating the Trans Youth Research Network: A Collaborative Research Endeavor. View Abstract
Predictors of Psychosocial Distress in Parents of Young Children with Disorders of Sex Development. View Abstract
Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. View Abstract
Effects of the Timing of Sex-Steroid Exposure in Adolescence on Adult Health Outcomes. View Abstract
Response to commentary on 'Parent perceptions of psychosocial care for children with differences of sex development'. View Abstract
Impact of Early Medical Treatment for Transgender Youth: Protocol for the Longitudinal, Observational Trans Youth Care Study. View Abstract
Parent perceptions of psychosocial care for children with differences of sex development. View Abstract
Paediatric and adult-onset male hypogonadism. View Abstract
Uncertainty and Posttraumatic Stress: Differences Between Mothers and Fathers of Infants with Disorders of Sex Development. View Abstract
TESTICULAR REGRESSION SYNDROME: PRACTICE VARIATION IN DIAGNOSIS AND MANAGEMENT. View Abstract
The Utility of Potassium Monitoring in Gender-Diverse Adolescents Taking Spironolactone. View Abstract
Ethical issues with early genitoplasty in children with disorders of sex development. View Abstract
Genetic evaluation of disorders of sex development: current practice and novel gene discovery. View Abstract
Parent-Rated Severity of Illness and Anxiety among Caregivers of Children Born with a Disorder of Sex Development Including Ambiguous Genitalia. View Abstract
Baseline Characteristics of Infants With Atypical Genital Development: Phenotypes, Diagnoses, and Sex of Rearing. View Abstract
Burden Testing of Rare Variants Identified through Exome Sequencing via Publicly Available Control Data. View Abstract
Assessing Sex Steroid Influence on Kisspeptin Responsiveness in Idiopathic Hypogonadotropic Hypogonadism. View Abstract
Genetics of pubertal timing. View Abstract
Management of pediatric patients with DSD and ambiguous genitalia: Balancing the child's moral claims to self-determination with parental values and preferences. View Abstract
Divergent responses to kisspeptin in children with delayed puberty. View Abstract
Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence. View Abstract
The Biological Contributions to Gender Identity and Gender Diversity: Bringing Data to the Table. View Abstract
Case 3-2018: A 5-Month-Old Boy with Hypoglycemia. View Abstract
Continuous Kisspeptin Administration in Postmenopausal Women: Impact of Estradiol on Luteinizing Hormone Secretion. View Abstract
Adult Consequences of Self-Limited Delayed Puberty. View Abstract
Recent findings on the genetics of disorders of sex development. View Abstract
A 46,XX Ovotesticular Disorder of Sex Development Likely Caused by a Steroidogenic Factor-1 (NR5A1) Variant. View Abstract
Prospective assessment of cosmesis before and after genital surgery. View Abstract
Two Unrelated Undervirilized 46,XY Males with Inherited NR5A1 Variants Identified by Whole-Exome Sequencing. View Abstract
Determinants of Power in Gene-Based Burden Testing for Monogenic Disorders. View Abstract
Phenotypic spectrum of POLR3B mutations: isolated hypogonadotropic hypogonadism without neurological or dental anomalies. View Abstract
Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty. View Abstract
Growth morbidity in patients with cloacal exstrophy: a 42-year experience. View Abstract
Fertility Issues for Patients with Hypogonadotropic Causes of Delayed Puberty. View Abstract
A shared genetic basis for self-limited delayed puberty and idiopathic hypogonadotropic hypogonadism. View Abstract
Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. View Abstract
Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism. View Abstract
Implantation failure in female Kiss1-/- mice is independent of their hypogonadic state and can be partially rescued by leukemia inhibitory factor. View Abstract
Redundancy in Kiss1 expression safeguards reproduction in the mouse. View Abstract
Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. View Abstract
LC-MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats. View Abstract
Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system. View Abstract
Effects of kisspeptin on hormone secretion in humans. View Abstract
Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. View Abstract
Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. View Abstract
Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications. View Abstract
GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. View Abstract
A needle in a haystack: mutations in GNRH1 as a rare cause of isolated GnRH deficiency. View Abstract
Kisspeptin resets the hypothalamic GnRH clock in men. View Abstract
Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta). View Abstract
Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1. View Abstract
Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. View Abstract
GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. View Abstract
Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. View Abstract
Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. View Abstract
Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11. View Abstract
Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. View Abstract